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Design and syntheses of some iminosugar derivatives as potential immunosuppressants
Zhang, Guo-Liang; Zheng, Xiu-Jing; Zhang, Li-He; Ye, Xin-Shan1
刊名MEDCHEMCOMM
2011-09-01
DOI10.1039/c1md00098e
2期:9页:909-917
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]LYSOSOMAL ALPHA-GALACTOSIDASE ; HEPATITIS-C VIRUS ; PHARMACOLOGICAL CHAPERONES ; GLYCOSIDASE INHIBITORS ; BIOLOGICAL-ACTIVITY ; FABRY LYMPHOBLASTS ; NATURAL OCCURRENCE ; GAUCHER-DISEASE ; HIV-1 GP120 ; IFN-GAMMA
英文摘要

Eleven new iminosugar derivatives were synthesized and the effects of these synthetic iminosugars on proliferation of the mouse splenocytes were evaluated by the cell counting kit-8 (CCK-8) assay. The preliminary structure-activity relationships were deduced from the experimental data. It was found that iminosugar 14 (IC(50) = 22 mu M) and its C-5 epimer 15 (IC(50) = 45 mu M) displayed the strongest inhibitory effects, and might hold potential as immunosuppressive agents.

语种英语
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000295710300015
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56760
专题北京大学药学院
作者单位1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Guo-Liang,Zheng, Xiu-Jing,Zhang, Li-He,et al. Design and syntheses of some iminosugar derivatives as potential immunosuppressants[J]. MEDCHEMCOMM,2011,2(9):909-917.
APA Zhang, Guo-Liang,Zheng, Xiu-Jing,Zhang, Li-He,&Ye, Xin-Shan.(2011).Design and syntheses of some iminosugar derivatives as potential immunosuppressants.MEDCHEMCOMM,2(9),909-917.
MLA Zhang, Guo-Liang,et al."Design and syntheses of some iminosugar derivatives as potential immunosuppressants".MEDCHEMCOMM 2.9(2011):909-917.
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