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学科主题: 药学
题名:
Design and syntheses of some iminosugar derivatives as potential immunosuppressants
作者: Zhang, Guo-Liang; Zheng, Xiu-Jing; Zhang, Li-He; Ye, Xin-Shan1
刊名: MEDCHEMCOMM
发表日期: 2011-09-01
DOI: 10.1039/c1md00098e
卷: 2, 期:9, 页:909-917
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Medicinal
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: LYSOSOMAL ALPHA-GALACTOSIDASE ; HEPATITIS-C VIRUS ; PHARMACOLOGICAL CHAPERONES ; GLYCOSIDASE INHIBITORS ; BIOLOGICAL-ACTIVITY ; FABRY LYMPHOBLASTS ; NATURAL OCCURRENCE ; GAUCHER-DISEASE ; HIV-1 GP120 ; IFN-GAMMA
英文摘要:

Eleven new iminosugar derivatives were synthesized and the effects of these synthetic iminosugars on proliferation of the mouse splenocytes were evaluated by the cell counting kit-8 (CCK-8) assay. The preliminary structure-activity relationships were deduced from the experimental data. It was found that iminosugar 14 (IC(50) = 22 mu M) and its C-5 epimer 15 (IC(50) = 45 mu M) displayed the strongest inhibitory effects, and might hold potential as immunosuppressive agents.

语种: 英语
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000295710300015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56760
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Guo-Liang,Zheng, Xiu-Jing,Zhang, Li-He,et al. Design and syntheses of some iminosugar derivatives as potential immunosuppressants[J]. MEDCHEMCOMM,2011,2(9):909-917.
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