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学科主题: 临床医学
题名:
Is interleukin-18 associated with polycystic ovary syndrome?
作者: Yang, Yan; Qiao, Jie; Li, Rong; Li, Mei-Zhi
刊名: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
发表日期: 2011-01-18
DOI: 10.1186/1477-7827-9-7
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: TYPE-2 DIABETES-MELLITUS ; REVISED 2003 CONSENSUS ; DIAGNOSTIC-CRITERIA ; INSULIN-RESISTANCE ; PERIPHERAL-BLOOD ; WOMEN ; PREVALENCE ; OBESITY ; SERUM ; IL-18
英文摘要:

Background: Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation.

Methods: To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured.

Results: Serum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T.

Conclusion: IL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.

语种: 英语
所属项目编号: 20090001110090 ; 30825038 ; 2007BA104B00
项目资助者: Ministry of Education of China ; National Natural Science Funds for Distinguished Young Scholar ; Ministry of Science &amp ; Technology of China
WOS记录号: WOS:000287155300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56761
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Yan,Qiao, Jie,Li, Rong,et al. Is interleukin-18 associated with polycystic ovary syndrome?[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2011,9.
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