北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Is interleukin-18 associated with polycystic ovary syndrome?
作者: Yang, Yan; Qiao, Jie; Li, Rong; Li, Mei-Zhi
刊名: REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
发表日期: 2011-01-18
DOI: 10.1186/1477-7827-9-7
卷: 9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism ; Reproductive Biology
研究领域[WOS]: Endocrinology & Metabolism ; Reproductive Biology
关键词[WOS]: TYPE-2 DIABETES-MELLITUS ; REVISED 2003 CONSENSUS ; DIAGNOSTIC-CRITERIA ; INSULIN-RESISTANCE ; PERIPHERAL-BLOOD ; WOMEN ; PREVALENCE ; OBESITY ; SERUM ; IL-18
英文摘要:

Background: Recent research show that polycystic ovary syndrome (PCOS) may have an association with low-grade chronic inflammation, IL-18 is considered as a strong risk marker of inflammation.

Methods: To investigate serum IL-18 concentrations in PCOS patients and focus on its relationship between obesity and insulin resistance (IR). Sixty consecutive women with PCOS and thirty controls were recruited. Serum level of IL-18 and fasting blood glucose, fasting insulin, follicle-stimulating hormone (FSH), luteinizing hormone (LH) and testosterone (T) were measured.

Results: Serum levels of IL-18 was significantly higher in the PCOS group than in the control group. Serum level of IL-18 was higher in the PCOS group with IR than in the PCOS group without IR. Serum level of IL-18 was higher in obese PCOS patients than in lean PCOS patients. Serum level of IL-18 was higher in lean PCOS patients than in the lean control group. Serum level of IL-18 in the PCOS group was positively related to BMI, IR index and T.

Conclusion: IL-18 level was increased in PCOS patients, and correlated with insulin resistance, obesity and hyperandrogenism.

语种: 英语
所属项目编号: 20090001110090 ; 30825038 ; 2007BA104B00
项目资助者: Ministry of Education of China ; National Natural Science Funds for Distinguished Young Scholar ; Ministry of Science &amp ; Technology of China
WOS记录号: WOS:000287155300001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56761
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100871, Peoples R China

Recommended Citation:
Yang, Yan,Qiao, Jie,Li, Rong,et al. Is interleukin-18 associated with polycystic ovary syndrome?[J]. REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY,2011,9.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Yan]'s Articles
[Qiao, Jie]'s Articles
[Li, Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Yan]‘s Articles
[Qiao, Jie]‘s Articles
[Li, Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace