IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats
Li, JL; Li, P; Feng, XH; Li, ZP; Hou, R; Han, C; Zhang, YY
关键词Cardiac Hypertrophy Cdna Microarray Gene Expression Losartan Pressure Overload
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2003-11-01
30期:11页:827-832
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]LEFT-VENTRICULAR HYPERTROPHY ; RECEPTOR BLOCKADE ; INHIBITION ; HEART ; CELLS ; CAPTOPRIL ; DISEASE ; FAMILY
英文摘要

1. In the present study, the effects of losartan on myocardial gene expression changes following cardiac hypertrophy were investigated.

2. Male Wistar rats were randomized to receive 5 or 30 mg/kg per day losartan (i.p.) 1 day after suprarenal abdominal aortic constriction. Two weeks later, cardiac morphology and function were recorded with echocardiography and mean arterial central pressure was measured using carotid catheters. Myocardial gene expression was assessed with cDNA microarrays.

3. The ratios of left ventricular weights to bodyweights, the posterior thickness of the left ventricle and mean arterial central pressure were significantly increased by aortic constriction and attenuated by losartan in a dose-related manner. Genes in different functional categories were regulated in pressure overload-induced cardiac hypertrophy and the majority of changes in gene expression were inhibited by losartan in a dose-dependent manner.

4. However, there were still some genes that were unaffected by losartan, even at a higher dose. In contrast, losartan, especially at a lower dose, was able to induce changes in the expression of several additional genes that were unregulated in simple aortic constriction.

5. In conclusion, losartan is able to inhibit pressure overload-induced cardiac hypertrophy, as well as the majority of pressure overload-related changes in gene expression. The genes that remained unaffected or those that were additionally induced by losartan are likely to be new targets for investigation or therapy.

语种英语
WOS记录号WOS:000186678900004
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56773
专题北京大学第三临床医学院_心血管内科
作者单位Peking Univ, Hosp 3, Inst Vasc Med, Reference Lab Educ Minist Mol Cardiol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Li, JL,Li, P,Feng, XH,et al. Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2003,30(11):827-832.
APA Li, JL.,Li, P.,Feng, XH.,Li, ZP.,Hou, R.,...&Zhang, YY.(2003).Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,30(11),827-832.
MLA Li, JL,et al."Effects of losartan on pressure overload-induced cardiac gene expression profiling in rats".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 30.11(2003):827-832.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, JL]的文章
[Li, P]的文章
[Feng, XH]的文章
百度学术
百度学术中相似的文章
[Li, JL]的文章
[Li, P]的文章
[Feng, XH]的文章
必应学术
必应学术中相似的文章
[Li, JL]的文章
[Li, P]的文章
[Feng, XH]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。