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Tumor-specific penetrating peptides-functionalized hyaluronic acid-D-alpha-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers
Liang, De-Sheng1,2; Su, Hai-Tao1,2; Liu, Yu-Jie1,2; Wang, Ai-Ting1,2; Qi, Xian-Rong1,2,3
关键词Tumor-homing Penetrating Peptide Tlyp-1 Site-specific Delivery Nrp-1 Receptor Cd44 Receptor D-alpha-tocopheryl Succinate (Tos)
刊名BIOMATERIALS
2015-12-01
DOI10.1016/j.biomaterials.2015.08.035
71页:11-23
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]DRUG-DELIVERY ; SOLID TUMORS ; MULTIFUNCTIONAL NANOPARTICLES ; THERAPEUTIC-EFFICACY ; ENDOTHELIAL-CELLS ; PROSTATE-CANCER ; GROWTH-FACTOR ; BRAIN GLIOMA ; IN-VIVO ; MICELLES
英文摘要

Poor site-specific delivery and incapable deep-penetration into tumor are the intrinsic limitations to successful chemotherapy. Here, the tumor-homing penetrating peptide tLyP-1-functionalized nanoparticles (tLPTS/HATS NPs), composed of two modularized amphiphilic conjugates of tLyP-1-PEG-TOS (tLPTS) and TOS-grafted hyaluronic acid (HATS), had been fabricated for tumor-targeted delivery of docetaxel (DTX). The prepared tLPTS/HATS NPs had about 110 nm in mean diameter, high drug encapsulation efficiency (93%), and sustained drug release behavior. In vitro studies demonstrated that the tLPTS/HATS NPs exhibited enhanced intracellular delivery and much better anti-invasion ability, cytotoxicity, and apoptosis against both invasive PC-3 and MDA-MB-231 cells as compared to the non-tLyP-1-functionalized HATS NPs. The remarkable penetrability and inhibitory effect on both PC-3 and MDA-MB-231 multicellular tumor spheroids were also identified for the tLPTS/HATS NPs. In vivo biodistribution imaging demonstrated the tLPTS/HATS NPs possessed much more lasting accumulation and extensive distribution throughout tumor regions than the HATS NPs. The higher in vivo therapeutic efficacy with lower systemic toxicity of the tLPTS/HATS NPs was also verified by the PC-3 xenograft model in athymic nude mice. These results suggested that the designed novel tLPTS/HATS NPs were endowed with tumor recognition, internalization, penetration, and anti-invasion, and thus might be a promising anticancer drug delivery vehicle for targeted cancer therapy. (C) 2015 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000362612800002
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56775
Collection北京大学药学院
北京大学药学院_药剂学系
作者单位1.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
3.Beijing Key Lab Mol Pharmaceut & New Drug Deliver, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liang, De-Sheng,Su, Hai-Tao,Liu, Yu-Jie,et al. Tumor-specific penetrating peptides-functionalized hyaluronic acid-D-alpha-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers[J]. BIOMATERIALS,2015,71:11-23.
APA Liang, De-Sheng,Su, Hai-Tao,Liu, Yu-Jie,Wang, Ai-Ting,&Qi, Xian-Rong.(2015).Tumor-specific penetrating peptides-functionalized hyaluronic acid-D-alpha-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers.BIOMATERIALS,71,11-23.
MLA Liang, De-Sheng,et al."Tumor-specific penetrating peptides-functionalized hyaluronic acid-D-alpha-tocopheryl succinate based nanoparticles for multi-task delivery to invasive cancers".BIOMATERIALS 71(2015):11-23.
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