IR@PKUHSC  > 北京大学口腔医学院  > 口腔修复科
学科主题口腔医学
Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration
Meng, Dan1; Dong, Limin2; Wen, Ying1; Xie, Qiufei3
关键词Calcium Phosphate Cement Chitosan Microspheres Injectable Scaffold Bone Regeneration
刊名MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
2015-02-01
DOI10.1016/j.msec.2014.11.049
47页:266-272
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
研究领域[WOS]Materials Science
关键词[WOS]IN-VIVO EVALUATION ; BIOLOGICAL-PROPERTIES ; HYDROXYAPATITE ; SCAFFOLD ; FABRICATION ; COMPOSITE ; APATITE ; SUBSTITUTION ; DIFFRACTION ; MONETITE
英文摘要

Calcium phosphate cements (CPCs) have been widely used as bone graft substitutes. However, the undesirable osteoinductivity and slow degradability of CPCs greatly hamper their clinical application. The aim of this study was to synthesize a type of injectable, bioactive cement. This was accomplished by incorporating chitosan microspheres into CPC. CPC containing chitosan microspheres was analyzed by X-ray diffraction (XRD) and scanning electron microscope (SEM). XRD showed that the hardened chitosan microsphere/CPC with different proportions of microspheres contained diffraction peaks of hydroxyapatite and chitosan. Compressive strength and dissolution in simulated body fluid were measured. The chitosan microsphere/CPC containing 10% (w/w) chitosan microspheres had a compressive strength of 14.78 +/- 0.67 MPa. Cavity defects were created in both femoral condylar regions of New Zealand White rabbits. Chitosan microsphere/CPC (composite group) and alpha-TCP/CPC (control group) were implanted separately into the bone defects of both femurs. X-ray analysis was performed to observe the filling of these bone defects 3 days after surgery. The extent of bone substitute degradation and new bone formation were evaluated by SEM and histological examination at 8, 16, and 24 weeks after implantation. These results showed far more new bone formation and degradation of the chitosan microsphere/CPC composite in the bone defects. These data indicate that a chitosan microsphere/CPC composite might be considered as a promising injectable material for the generation of new bone tissue. (C) 2014 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000347581600032
项目编号30772447
资助机构National Natural Science Foundation of China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56777
专题北京大学口腔医学院_口腔修复科
作者单位1.Capital Med Univ, Beijing Stomatol Hosp, Dept Prosthodont, Beijing 100050, Peoples R China
2.Tsinghua Univ, Inst Nucl & New Energy Technol, Being Key Lab Fine Ceram, Beijing 100084, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Meng, Dan,Dong, Limin,Wen, Ying,et al. Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2015,47:266-272.
APA Meng, Dan,Dong, Limin,Wen, Ying,&Xie, Qiufei.(2015).Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration.MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,47,266-272.
MLA Meng, Dan,et al."Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration".MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS 47(2015):266-272.
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