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学科主题: 口腔医学
题名:
Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration
作者: Meng, Dan1; Dong, Limin2; Wen, Ying1; Xie, Qiufei3
关键词: Calcium phosphate cement ; Chitosan ; Microspheres ; Injectable scaffold ; Bone regeneration
刊名: MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
发表日期: 2015-02-01
DOI: 10.1016/j.msec.2014.11.049
卷: 47, 页:266-272
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: IN-VIVO EVALUATION ; BIOLOGICAL-PROPERTIES ; HYDROXYAPATITE ; SCAFFOLD ; FABRICATION ; COMPOSITE ; APATITE ; SUBSTITUTION ; DIFFRACTION ; MONETITE
英文摘要:

Calcium phosphate cements (CPCs) have been widely used as bone graft substitutes. However, the undesirable osteoinductivity and slow degradability of CPCs greatly hamper their clinical application. The aim of this study was to synthesize a type of injectable, bioactive cement. This was accomplished by incorporating chitosan microspheres into CPC. CPC containing chitosan microspheres was analyzed by X-ray diffraction (XRD) and scanning electron microscope (SEM). XRD showed that the hardened chitosan microsphere/CPC with different proportions of microspheres contained diffraction peaks of hydroxyapatite and chitosan. Compressive strength and dissolution in simulated body fluid were measured. The chitosan microsphere/CPC containing 10% (w/w) chitosan microspheres had a compressive strength of 14.78 +/- 0.67 MPa. Cavity defects were created in both femoral condylar regions of New Zealand White rabbits. Chitosan microsphere/CPC (composite group) and alpha-TCP/CPC (control group) were implanted separately into the bone defects of both femurs. X-ray analysis was performed to observe the filling of these bone defects 3 days after surgery. The extent of bone substitute degradation and new bone formation were evaluated by SEM and histological examination at 8, 16, and 24 weeks after implantation. These results showed far more new bone formation and degradation of the chitosan microsphere/CPC composite in the bone defects. These data indicate that a chitosan microsphere/CPC composite might be considered as a promising injectable material for the generation of new bone tissue. (C) 2014 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 30772447
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000347581600032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56777
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Stomatol Hosp, Dept Prosthodont, Beijing 100050, Peoples R China
2.Tsinghua Univ, Inst Nucl & New Energy Technol, Being Key Lab Fine Ceram, Beijing 100084, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China

Recommended Citation:
Meng, Dan,Dong, Limin,Wen, Ying,et al. Effects of adding resorbable chitosan microspheres to calcium phosphate cements for bone regeneration[J]. MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS,2015,47:266-272.
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