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学科主题: 药学
题名:
Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells
作者: Wang, Nan1; Wang, Li-Wen2; Gou, Bao-Di1; Zhang, Tian-Lan1,2; Wang, Kui1
关键词: Realgar ; Arsenic sulfide ; Differentiation ; MAPK pathway ; HL-60
刊名: CELL BIOLOGY INTERNATIONAL
发表日期: 2008-12-01
DOI: 10.1016/j.cellbi.2008.08.017
卷: 32, 期:12, 页:1497-1505
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology
研究领域[WOS]: Cell Biology
关键词[WOS]: ACUTE PROMYELOCYTIC LEUKEMIA ; ACTIVATED PROTEIN-KINASE ; 1,25-DIHYDROXYVITAMIN D-3-INDUCED DIFFERENTIATION ; ARSENIC TRIOXIDE ; RETINOIC ACID ; SIGNALING PATHWAYS ; MYELOID-LEUKEMIA ; HL60 CELLS ; IN-VITRO ; INHIBITOR
英文摘要:

The clinical efficacy and safety of realgar (arsenic sulfide, As(4)S(4)) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL-60 cells. Treatment with RNPs at 6 mu M for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP-induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP-induced differentiation in HL-60 cells. (c) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 20271005 ; 20571006 ; 2062007
项目资助者: National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Education Commission ; Beijing Talent Project
WOS记录号: WOS:000261001100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56778
Appears in Collections:北京大学药学院_化学生物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China

Recommended Citation:
Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,et al. Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells[J]. CELL BIOLOGY INTERNATIONAL,2008,32(12):1497-1505.
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