IR@PKUHSC  > 北京大学药学院  > 化学生物学系
学科主题药学
Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells
Wang, Nan1; Wang, Li-Wen2; Gou, Bao-Di1; Zhang, Tian-Lan1,2; Wang, Kui1
关键词Realgar Arsenic Sulfide Differentiation Mapk Pathway Hl-60
刊名CELL BIOLOGY INTERNATIONAL
2008-12-01
DOI10.1016/j.cellbi.2008.08.017
32期:12页:1497-1505
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]ACUTE PROMYELOCYTIC LEUKEMIA ; ACTIVATED PROTEIN-KINASE ; 1,25-DIHYDROXYVITAMIN D-3-INDUCED DIFFERENTIATION ; ARSENIC TRIOXIDE ; RETINOIC ACID ; SIGNALING PATHWAYS ; MYELOID-LEUKEMIA ; HL60 CELLS ; IN-VITRO ; INHIBITOR
英文摘要

The clinical efficacy and safety of realgar (arsenic sulfide, As(4)S(4)) in the treatment of acute promyelocytic leukemia in China have given rise to an upsurge in research on the underlying mechanism. We prepared realgar nanoparticles (RNPs) to examine their effect on the differentiation of HL-60 cells. Treatment with RNPs at 6 mu M for 72 h induced cell differentiation that was assessed by morphological change, NBT reductive ability, and elevation of CD11b expression at both mRNA and protein levels. The RNP-induced differentiation was synergized, enhanced and suppressed by the inhibition of p38 MAPK, JNK and ERK pathways, respectively. Our findings demonstrate that MAPK signaling pathways are closely related to the RNP-induced differentiation in HL-60 cells. (c) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000261001100004
项目编号20271005 ; 20571006 ; 2062007
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; Beijing Municipal Education Commission ; Beijing Talent Project
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56778
专题北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Capital Med Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,et al. Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells[J]. CELL BIOLOGY INTERNATIONAL,2008,32(12):1497-1505.
APA Wang, Nan,Wang, Li-Wen,Gou, Bao-Di,Zhang, Tian-Lan,&Wang, Kui.(2008).Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells.CELL BIOLOGY INTERNATIONAL,32(12),1497-1505.
MLA Wang, Nan,et al."Realgar-induced differentiation is associated with MAPK pathways in HL-60 cells".CELL BIOLOGY INTERNATIONAL 32.12(2008):1497-1505.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Nan]的文章
[Wang, Li-Wen]的文章
[Gou, Bao-Di]的文章
百度学术
百度学术中相似的文章
[Wang, Nan]的文章
[Wang, Li-Wen]的文章
[Gou, Bao-Di]的文章
必应学术
必应学术中相似的文章
[Wang, Nan]的文章
[Wang, Li-Wen]的文章
[Gou, Bao-Di]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。