IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains
Zhao, Er-Ying1; Bao, Hong-Xia1,2; Tang, Le1,2; Zou, Qing-Hua1,3; Liu, Wei-Qiao4,5; Zhu, Da-Ling6; Chin, Jessica4,5; Dong, Ying-Ying4,5; Li, Yong-Guo7; Cao, Feng-Lin7; Poppe, Cornelis8; Sanderson, Kenneth E.4,5; Johnston, Randal N.9,10; Zhou, Daoguo11; Liu, Gui-Rong1; Liu, Shu-Lin1,2,3,4,5,6,7
关键词Salmonella typhimurium DT104 Antimicrobial resistance SGI-1
刊名MOLECULAR GENETICS AND GENOMICS
2013-11-01
DOI10.1007/s00438-013-0762-8
288期:11页:549-557
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
研究领域[WOS]Biochemistry & Molecular Biology ; Genetics & Heredity
关键词[WOS]RIBOSOMAL-RNA ; CLEAVAGE MAP ; ENTERICA ; RESISTANCE ; SEQUENCE ; TYPHI ; IDENTIFICATION ; GENES ; ELECTROPHORESIS ; CHOLERAESUIS
英文摘要

DT104 emerged as a new branch of Salmonella typhimurium with resistance to multiple antimicrobials. To reveal some general genomic features of DT104 for clues of evolutionary events possibly associated with the emergence of this relatively new type of this pathogen, we mapped 11 independent DT104 strains and compared them with non-DT104 S. typhimurium strains. We found that all 11 DT104 strains contained three insertions absent in non-DT104 strains, i.e., the previously reported ST104, ST104B and ST64B. However, SGI-1, a genomic island known to be responsible for DT104 multidrug resistance, was not present in all DT104 strains examined in this study: one DT104 strain did not contain SGI-1 but carried a 144 kb plasmid, suggesting possible evolutionary relationships between the two DNA elements in the development of antimicrobial resistance.

语种英语
WOS记录号WOS:000326263900001
项目编号256177 ; NSFC31100134 ; NSFC30970078 ; NSFC30970119 ; 81030029 ; 81271786 ; YJSCX2012-197HLJ ; NSFC-NIH 81161120416 ; 20092307110001
资助机构Genome Canada ; National Natural Science Foundation of China ; Natural Science Foundation of Heilongjiang Province of China ; Heilongjiang Innovation Endowment Award ; National Natural Science Foundation of China and National Institutes of Health of USA ; Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP)
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56782
专题北京大学基础医学院_病原生物学系
作者单位1.Univ Calgary, Dept Microbiol, Calgary, AB, Canada
2.Univ Calgary, Dept Infect Dis, Calgary, AB, Canada
3.Publ Hlth Agcy Canada, Lab Foodborne Zoonoses, Guelph, ON, Canada
4.Univ Calgary, Dept Biochem, Calgary, AB, Canada
5.Univ Calgary, Dept Mol Biol, Calgary, AB, Canada
6.Harbin Med Univ, Genom Res Ctr, State Prov Key Labs Biomed Pharmaceut China 1, Harbin 150081, Peoples R China
7.Harbin Med Univ, HMU UCFM Ctr Infect & Genom, Harbin 150081, Peoples R China
8.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100871, Peoples R China
9.Harbin Med Univ, Fac Pharm, Dept Biopharmaceut, Harbin 150081, Peoples R China
10.Harbin Med Univ, Hosp 1, Genet Diag Lab, Harbin 150081, Peoples R China
11.Purdue Univ, Dept Biol Sci, W Lafayette, IN 47907 USA
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GB/T 7714
Zhao, Er-Ying,Bao, Hong-Xia,Tang, Le,et al. Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains[J]. MOLECULAR GENETICS AND GENOMICS,2013,288(11):549-557.
APA Zhao, Er-Ying.,Bao, Hong-Xia.,Tang, Le.,Zou, Qing-Hua.,Liu, Wei-Qiao.,...&Liu, Shu-Lin.(2013).Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains.MOLECULAR GENETICS AND GENOMICS,288(11),549-557.
MLA Zhao, Er-Ying,et al."Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains".MOLECULAR GENETICS AND GENOMICS 288.11(2013):549-557.
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