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学科主题: 药学
题名:
Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles
作者: Yu, JX; Li, ZJ; Lu, WJ; Zhang, S; Cai, MS
刊名: TETRAHEDRON-ASYMMETRY
发表日期: 2003-09-05
DOI: 10.1016/S0957-4166(03)00491-9
卷: 14, 期:17, 页:2507-2513
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
研究领域[WOS]: Chemistry
关键词[WOS]: DEHYDROGENASE-ACTIVITY ; CONDENSATION PRODUCTS ; ANTIVIRAL ACTIVITY ; D-GLUCOSE ; NUCLEOSIDES ; HYDRAZONES ; DERIVATIVES ; GUANYLHYDRAZONES ; AMINOGUANIDINE ; TAUTOMERISM
英文摘要:

1-(beta-D- and alpha-L-Glycopyranosyl)-5-methyl-1H-1,2,4-triazoles 7. 13-15 were synthesized stereoselectively from the corresponding glycopyranosyl aminoguanidine nitrates 1-3 in boiling acetic anhydride or from N-1-(acetylated -beta- or or alpha-L-glycopyranosylamino)-N-1,N-2,N-3-triacetylguanidines 8-10 using catalytic amounts of NaOMe. Structures were confirmed by elemental analyses, IR. NMR and MS and possible mechanisms are discussed. In vitro antitumor and immuno activities are presented. (C) 2003 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000185311200006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56788
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Xinjiang Univ, Dept Chem, Wulumqi 830046, Peoples R China
2.Wuyi Univ, Dept Chem, Jiangmen 529020, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Yu, JX,Li, ZJ,Lu, WJ,et al. Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles[J]. TETRAHEDRON-ASYMMETRY,2003,14(17):2507-2513.
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