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Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles
Yu, JX; Li, ZJ; Lu, WJ; Zhang, S; Cai, MS
刊名TETRAHEDRON-ASYMMETRY
2003-09-05
DOI10.1016/S0957-4166(03)00491-9
14期:17页:2507-2513
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Inorganic & Nuclear ; Chemistry, Organic ; Chemistry, Physical
研究领域[WOS]Chemistry
关键词[WOS]DEHYDROGENASE-ACTIVITY ; CONDENSATION PRODUCTS ; ANTIVIRAL ACTIVITY ; D-GLUCOSE ; NUCLEOSIDES ; HYDRAZONES ; DERIVATIVES ; GUANYLHYDRAZONES ; AMINOGUANIDINE ; TAUTOMERISM
英文摘要

1-(beta-D- and alpha-L-Glycopyranosyl)-5-methyl-1H-1,2,4-triazoles 7. 13-15 were synthesized stereoselectively from the corresponding glycopyranosyl aminoguanidine nitrates 1-3 in boiling acetic anhydride or from N-1-(acetylated -beta- or or alpha-L-glycopyranosylamino)-N-1,N-2,N-3-triacetylguanidines 8-10 using catalytic amounts of NaOMe. Structures were confirmed by elemental analyses, IR. NMR and MS and possible mechanisms are discussed. In vitro antitumor and immuno activities are presented. (C) 2003 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000185311200006
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56788
专题北京大学药学院
作者单位1.Xinjiang Univ, Dept Chem, Wulumqi 830046, Peoples R China
2.Wuyi Univ, Dept Chem, Jiangmen 529020, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, JX,Li, ZJ,Lu, WJ,et al. Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles[J]. TETRAHEDRON-ASYMMETRY,2003,14(17):2507-2513.
APA Yu, JX,Li, ZJ,Lu, WJ,Zhang, S,&Cai, MS.(2003).Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles.TETRAHEDRON-ASYMMETRY,14(17),2507-2513.
MLA Yu, JX,et al."Novel stereoselective synthesis of 1-(beta-D- and alpha-L-glycopyranosyl)-5-methyl-1H-1,2,4-triazoles".TETRAHEDRON-ASYMMETRY 14.17(2003):2507-2513.
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