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学科主题: 临床医学
题名:
Animal Model of Dermatophytosis
作者: Shimamura, Tsuyoshi1,2; Kubota, Nobuo2; Shibuya, Kazutoshi1,3
刊名: JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY
发表日期: 2012
DOI: 10.1155/2012/125384
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: GUINEA-PIG MODEL ; EXPERIMENTAL TINEA-PEDIS ; TRICHOPHYTON-MENTAGROPHYTES-DERMATOPHYTOSIS ; IMIDAZOLE ANTIMYCOTIC AGENT ; TOPICAL ANTIFUNGAL AGENT ; THERAPEUTIC-EFFICACY ; IN-VITRO ; INVIVO ACTIVITY ; NAIL LACQUER ; BUTENAFINE HYDROCHLORIDE
英文摘要:

Dermatophytosis is superficial fungal infection caused by dermatophytes that invade the keratinized tissue of humans and animals. Lesions from dermatophytosis exhibit an inflammatory reaction induced to eliminate the invading fungi by using the host′s normal immune function. Many scientists have attempted to establish an experimental animal model to elucidate the pathogenesis of human dermatophytosis and evaluate drug efficacy. However, current animal models have several issues. In the present paper, we surveyed reports about the methodology of the dermatophytosis animal model for tinea corporis, tinea pedis, and tinea unguium and discussed future prospects.

语种: 英语
项目资助者: Health Science Research Grants for Research on Emerging and Re-emerging Infectious Diseases ; Strategic Basis on Research Grounds for Non-governmental Schools at Heisei from Ministry of Education, Culture, Sports, Science and Technology of Japan ; Strategic Research Foundation from Ministry of Education, Culture, Sports, Science and Technology of Japan ; Pfizer Inc. ; Janssen Pharmaceutical K. K. ; Dainippon Sumitomo Pharma Co.
WOS记录号: WOS:000303722600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56802
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Toho Univ, Sch Med, Dept Surg Pathol, Ota Ku, Tokyo 1438541, Japan
2.POLA Pharma Inc, R&D Labs, Totsuka Ku, Yokohama, Kanagawa 2440812, Japan
3.Peking Univ, Hosp 1, Dept Dermatol, Beijing 100034, Peoples R China

Recommended Citation:
Shimamura, Tsuyoshi,Kubota, Nobuo,Shibuya, Kazutoshi. Animal Model of Dermatophytosis[J]. JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY,2012.
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