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学科主题基础医学
Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet
Wang, Xian-Wei1; Hu, Lin2; Zeng, Zhu1; Yao, Wei-Juan1; Han, Jing-Yan3; Zhang, Ying-Yu1; Xu, Xiao-Feng1; Liu, Yu-Ying3; Ka, Wei-Bo4; Sun, Da-Gong4; Wen, Zong-Yao1; Chien, Shu5
关键词Myakuryu hyperlipidemia hemorheological characteristics
刊名BIORHEOLOGY
2008
DOI10.3233/BIR-2008-0502
45期:5页:587-598
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical ; Hematology
资助者National Natural Science Foundations of China ; National Natural Science Foundations of China
研究领域[WOS]Biophysics ; Engineering ; Hematology
关键词[WOS]BLOOD-CELL AGGREGATION ; HUMAN ERYTHROCYTES ; PEROXISOME PROLIFERATORS ; MEMBRANE MICROVISCOSITY ; PANAX-NOTOGINSENG ; LIPID-METABOLISM ; GENE-EXPRESSION ; LOW-VISCOSITY ; RBC MEMBRANE ; FLOW
英文摘要

There is evidence that hyperlipidemia can induce hemorheological and microcirculatory disturbances. Myakuryu, a Chinese traditional medicine is efficacious in promoting lipid metabolism and protecting oxidative stress, but whether this drug can ameliorate rheologic disturbances caused by hyperlipidemia is still unknown. The present study was conducted to investigate the effects of myakuryu on hemorheological and microcirculatory disturbances induced by hyperlipidemia. Wistar rats were divided into a group on control diet (n = 8) and a group on high-fat diet (HFD, n = 44). Eight weeks later, plasma triglyceride (TG) and total cholesterol (TC) were determined. Sixteen animals with the highest levels of hyperlipidemia from the HFD group were randomly divided into two sub-groups: the untreated hyperlipidemia group (n = 8) and the group treated with myakuryu (n = 8). At the end of the sixteenth week, rheological and microcirculatory parameters were measured. Chemical analysis showed that myakuryu treatment caused significant reductions of plasma TG and TC levels (P < 0.01), and the cholesterol/phospholipid ratio in the erythrocyte membrane (P < 0.05). Rheological and microcirculatory measurements showed that myakuryu treatment led to a significant decrease in the erythrocyte aggregation index, plasma viscosity and blood viscosity at shear rates of 50, 100 and 150 s(-1) and in adherent leukocytes in mesenteric venules. There was a significant increase in erythrocyte deformation, electrophoretic mobility, membrane fluidity and F- actin content in the erythrocyte membrane as well as in red cell velocity in mesenteric venules. Our findings suggest that myakuryu treatment can improve blood flow and reduce adherent leukocytes in the venules of rats fed with HFD by ameliorating blood viscosity, erythrocyte deformability and aggregation, and other hemorheological characteristics.

语种英语
所属项目编号10572007 ; 30770532
资助者National Natural Science Foundations of China ; National Natural Science Foundations of China
WOS记录号WOS:000261026100004
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56804
专题基础医学院_生物物理学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Biophys, Beijing 100083, Peoples R China
2.Guizhou Univ, Dept Phys, Guiyang, Guizhou, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Dept Med Phys, Beijing 100083, Peoples R China
5.Univ Calif San Diego, Dept Bioengn & Med, La Jolla, CA 92093 USA
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GB/T 7714
Wang, Xian-Wei,Hu, Lin,Zeng, Zhu,et al. Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet[J]. BIORHEOLOGY,2008,45(5):587-598.
APA Wang, Xian-Wei.,Hu, Lin.,Zeng, Zhu.,Yao, Wei-Juan.,Han, Jing-Yan.,...&Chien, Shu.(2008).Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet.BIORHEOLOGY,45(5),587-598.
MLA Wang, Xian-Wei,et al."Effects of myakuryu on hemorheological characteristics and mesenteric microcirculation of rats fed with a high-fat diet".BIORHEOLOGY 45.5(2008):587-598.
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