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Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C
Shao, Wei; Zhao, Shan; Liu, Zhaofei; Zhang, Jianzhong; Ma, Shujun; Sato, J. Denry; Zhang, Peng; Tong, Mei; Han, Jiping; Wang, Yan; Bai, Dongmei; Wang, Fan; Sun, Le
关键词Epidermal Growth Factor Receptor (Egfr) La22 Xenograft Immunotherapy Immunoconjugate
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2006-10-20
DOI10.1016/j.bbrc.2006.08.114
349期:2页:816-824
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ACUTE MYELOID-LEUKEMIA ; EGF RECEPTOR ; CANCER ; THERAPY ; CARCINOMA ; BINDING ; TARGET ; CELLS
英文摘要

Anti-EGFR monoclonal antibodies LA22 and Erbitux bind to different epitopes of EGFR. The chemimmunoconjugates of MMC with LA22 or Erbitux were prepared, and in vitro cytotoxicity assays with A549 cells showed that LA22-MMC was much more potent than Erbitux or Erbitux-MMC. Viabilities of A549 cells treated with LA22-MMC, Erbitux or Erbitux-MMC were 35%, 94%, and 81%, respectively. Immunoscintigraphy of xenografts of human A431 and A549 cells in nude mice both showed that I-125-labeled-LA22-MMC enriched in tumor sites prominently. Most importantly, in vivo assays showed LA22-MMC was significantly more effective than free drug MMC in the treatment of subcutaneous xenografts of human A431 cells in nude mice (83% inhibition for LA22-MMC and 30% for MMC). We concluded that LA22-MMC could be a very potent drug for treatment of solid tumors. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000240791800048
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56805
专题北京大学医药卫生分析中心
作者单位1.Welson Pharmaceut Inc, Ellicott City, MD 21042 USA
2.Beijing 306 Hosp, Dept Pathol, Beijing 100101, Peoples R China
3.Mt Desert Isl Biol Lab, Salsbury Cove, ME 04672 USA
4.Peking Univ, Med Isotopes Res Ctr, Beijing 100083, Peoples R China
5.Employees Hosp, CNPC Liaoyang Petrochem Fiber Co, Liaoning, Peoples R China
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GB/T 7714
Shao, Wei,Zhao, Shan,Liu, Zhaofei,et al. Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2006,349(2):816-824.
APA Shao, Wei.,Zhao, Shan.,Liu, Zhaofei.,Zhang, Jianzhong.,Ma, Shujun.,...&Sun, Le.(2006).Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,349(2),816-824.
MLA Shao, Wei,et al."Inhibition of human tumor xenograft growth in nude mice by a conjugate of monoclonal antibody LA22 to epidermal growth factor receptor with anti-tumor antibiotics mitomycin C".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 349.2(2006):816-824.
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