IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection
Shen, Tao1; Chen, Xiangmei1; Xu, Qiang1; Lu, Fengmin1; Liu, Shuang2
刊名ARCHIVES OF VIROLOGY
2010-05-01
DOI10.1007/s00705-010-0626-z
155期:5页:627-634
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Virology
研究领域[WOS]Virology
关键词[WOS]HEPATITIS-C VIRUS ; HUMAN-IMMUNODEFICIENCY-VIRUS ; IN-VITRO PROLIFERATION ; IMMUNE-RESPONSE ; VIRAL CLEARANCE ; IL-7 RECEPTOR ; HIV-INFECTION ; MEMORY ; PERSISTENCE ; LYMPHOCYTES
英文摘要

Attenuated CD4+ T-cell-mediated immune responses are involved in persistence of HCV infection, but the mechanism remains undefined. In this study, the proportions of CD4+ T cell subsets, na < ve, central memory, effector memory and effector cells, along with CD25 (IL-2R alpha) and CD127 (IL-7R alpha) expression on different CD4+ T cell subsets, were measured by polychromatic flow cytometry in 24 chronic HCV-infected individuals and 21 healthy controls. A significant decrease in na < ve CD4+ T cells and an increase of central memory and effector memory CD4+ T cells were found in HCV-infected patients compared with healthy controls. HCV-infected patients showed a lower level of CD127 expression in all CD4+ T cells subsets, especially in central memory and effector CD4+ T cells. In terms of total CD4+ T cells, an increase in CD25+ regular T cells (CD4+ CD25+ CD127lo) was found in HCV-infected patients. Interestingly, na < ve CD4+ T cells showed increased CD25 expression, while effector memory and effector CD4+ T cells had lower CD25 expression. These data indicated that variations in different fractions of CD4+ T cells, including the phenotypic profile and expression level of CD25 and CD127, may be associated with low efficiency of immune response in chronic HCV infection. These results will strengthen the understanding of pathogenesis and dysfunction of CD4+ T cell immunity during long-term HCV persistence.

语种英语
WOS记录号WOS:000277164900001
项目编号2008ZX10002-013 ; BMU20090529-123
资助机构China National Science and Technology ; Peking University Health Science Center
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56806
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing You an Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China
推荐引用方式
GB/T 7714
Shen, Tao,Chen, Xiangmei,Xu, Qiang,et al. Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection[J]. ARCHIVES OF VIROLOGY,2010,155(5):627-634.
APA Shen, Tao,Chen, Xiangmei,Xu, Qiang,Lu, Fengmin,&Liu, Shuang.(2010).Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection.ARCHIVES OF VIROLOGY,155(5),627-634.
MLA Shen, Tao,et al."Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection".ARCHIVES OF VIROLOGY 155.5(2010):627-634.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Distributional chara(399KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shen, Tao]的文章
[Chen, Xiangmei]的文章
[Xu, Qiang]的文章
百度学术
百度学术中相似的文章
[Shen, Tao]的文章
[Chen, Xiangmei]的文章
[Xu, Qiang]的文章
必应学术
必应学术中相似的文章
[Shen, Tao]的文章
[Chen, Xiangmei]的文章
[Xu, Qiang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。