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学科主题: 基础医学
题名:
Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection
作者: Shen, Tao1; Chen, Xiangmei1; Xu, Qiang1; Lu, Fengmin1; Liu, Shuang2
刊名: ARCHIVES OF VIROLOGY
发表日期: 2010-05-01
DOI: 10.1007/s00705-010-0626-z
卷: 155, 期:5, 页:627-634
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Virology
研究领域[WOS]: Virology
关键词[WOS]: HEPATITIS-C VIRUS ; HUMAN-IMMUNODEFICIENCY-VIRUS ; IN-VITRO PROLIFERATION ; IMMUNE-RESPONSE ; VIRAL CLEARANCE ; IL-7 RECEPTOR ; HIV-INFECTION ; MEMORY ; PERSISTENCE ; LYMPHOCYTES
英文摘要:

Attenuated CD4+ T-cell-mediated immune responses are involved in persistence of HCV infection, but the mechanism remains undefined. In this study, the proportions of CD4+ T cell subsets, na < ve, central memory, effector memory and effector cells, along with CD25 (IL-2R alpha) and CD127 (IL-7R alpha) expression on different CD4+ T cell subsets, were measured by polychromatic flow cytometry in 24 chronic HCV-infected individuals and 21 healthy controls. A significant decrease in na < ve CD4+ T cells and an increase of central memory and effector memory CD4+ T cells were found in HCV-infected patients compared with healthy controls. HCV-infected patients showed a lower level of CD127 expression in all CD4+ T cells subsets, especially in central memory and effector CD4+ T cells. In terms of total CD4+ T cells, an increase in CD25+ regular T cells (CD4+ CD25+ CD127lo) was found in HCV-infected patients. Interestingly, na < ve CD4+ T cells showed increased CD25 expression, while effector memory and effector CD4+ T cells had lower CD25 expression. These data indicated that variations in different fractions of CD4+ T cells, including the phenotypic profile and expression level of CD25 and CD127, may be associated with low efficiency of immune response in chronic HCV infection. These results will strengthen the understanding of pathogenesis and dysfunction of CD4+ T cell immunity during long-term HCV persistence.

语种: 英语
所属项目编号: 2008ZX10002-013 ; BMU20090529-123
项目资助者: China National Science and Technology ; Peking University Health Science Center
WOS记录号: WOS:000277164900001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56806
Appears in Collections:基础医学院_病原生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Capital Med Univ, Beijing You an Hosp, Artificial Liver Ctr, Beijing 100069, Peoples R China

Recommended Citation:
Shen, Tao,Chen, Xiangmei,Xu, Qiang,et al. Distributional characteristics of CD25 and CD127 on CD4+ T cell subsets in chronic HCV infection[J]. ARCHIVES OF VIROLOGY,2010,155(5):627-634.
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