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学科主题: 临床医学
题名:
Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma
作者: Zhi, Xu1,2; Lamperska, Katarzyna3; Golusinski, Pawel4; Schork, Nicholas J.5; Luczewski, Lukasz4; Golusinski, Wojciech4; Masternak, Michal M.1
关键词: Oral cancer ; IGF1 ; IGF2 ; Survival
刊名: GROWTH HORMONE & IGF RESEARCH
发表日期: 2014-08-01
DOI: 10.1016/j.ghir.2014.04.003
卷: 24, 期:4, 页:137-141
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Endocrinology & Metabolism
研究领域[WOS]: Cell Biology ; Endocrinology & Metabolism
关键词[WOS]: ORAL-CANCER ; FACTOR-I ; BINDING PROTEIN-3 ; PROSTATE-CANCER ; UP-REGULATION ; RISK ; ALCOHOL ; TOBACCO
英文摘要:

Insulin-like growth factors (IGF) 1 and 2 are known as potential mitogens for normal and neoplastic cells. IGF2 is a main fetal growth factor while IGF1 is activated through growth hormone action during postnatal growth and development. However, there is strong evidence that activation of IGF2 by its E2F transcription factor 3 (E2F3) is present in different types of cancer. Also high levels of IGF1 strongly correlate with cancer development due to anti-apoptotic properties and enhancement of cancer cell differentiation, which can be attenuated by IGFBP3. Head and neck cancer is known as one of the six most common human cancers. The main risk factor for head and neck cancer is consumption of tobacco and alcohol as well as viral infection and bacterial infection by stimulation of chronic local inflammation. There is also a genetic basis for this form of cancer; however, the genetic markers are not yet established. In this study we investigated the levels of the expression of IGF2, IGF1, E2F3 and IGFBP3 in human cancers and healthy tissues surrounding the tumor obtained from each of 41 patients. Our study indicated that there is no alteration of the levels of expression of IGF2, E2F3 and IGF1 in head and neck squamous cell carcinoma (HNSCC) cases studied in selected experimental population, but there was evidence for upregulation of pro-apoptotic IGFBP3 in cancer when comparing to healthy tissue. These important findings indicate that insulin-growth factors are not directly associated with HNSCC showing some variability between patients and location of tumor. However, elevated level of IGFBP3 suggests possible regulatory role of IGF signal by its binding protein in this type of tumor. (C) 2014 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: R01AG032290 ; N N403 186934 ; 5 UL1 RR025774
项目资助者: National Institute on Aging of the National Institutes of Health ; Polish National Science Centre ; NIH
WOS记录号: WOS:000339701900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56807
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: 1.Univ Cent Florida, Burnett Sch Biomed Sci, Coll Med, Orlando, FL 32827 USA
2.Peking Univ, Third Hosp, Dept Obstet & Gynecol, Ctr Reprod Med, Beijing 100191, Peoples R China
3.Greater Poland Canc Ctr, Dept Canc Genet, PL-61866 Poznan, Poland
4.Poznan Univ Med Sci, Greater Poland Canc Ctr, Dept Head & Neck Surg, PL-61866 Poznan, Poland
5.J Craig Venter Inst, La Jolla, CA 92037 USA

Recommended Citation:
Zhi, Xu,Lamperska, Katarzyna,Golusinski, Pawel,et al. Expression levels of insulin-like growth factors 1 and 2 in head and neck squamous cell carcinoma[J]. GROWTH HORMONE & IGF RESEARCH,2014,24(4):137-141.
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