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学科主题临床医学
Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties
Guan, Li1; Zhang, Yan-Lin1; Li, Zong-Yang1; Zhu, Ming-Xia1; Yao, Wei-Juan2; Zhao, Jin-Yuan1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/526483
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]CARBON-MONOXIDE INTOXICATION ; HEMORHEOLOGICAL CHANGES ; RBC DEFORMABILITY ; APOPTOSIS ; VISCOSITY ; CELLS ; MICRODIALYSIS ; AGGREGATION ; MECHANISM ; STRIATUM
英文摘要

Carbon monoxide (CO) poisoning causes the major injury and death due to poisoning worldwide. The most severe damage via CO poisoning is brain injury and mortality. Delayed encephalopathy after acute CO poisoning (DEACMP) occurs in forty percent of the survivors of acute CO exposure. But the pathological cause for DEACMP is not well understood. And the corresponding therapy is not well developed. In order to investigate the effects of salvianolic acid (SA) on brain injury caused by CO exposure from the view point of hemorheology, we employed a rat model and studied the dynamic of blood changes in the hemorheological and coagulative properties over acute CO exposure. Compared with the groups of CO and 20% mannitol + CO treatments, the severe hippocampal injury caused by acute CO exposure was prevented by SA treatment. These protective effects were associated with the retaining level of hematocrit (Hct), plasma viscosity, fibrinogen, whole blood viscosities and malondialdehyde (MDA) levels in red blood cells (RBCs). These results indicated that SA treatment could significantly improve the deformation of erythrocytes and prevent the damage caused by CO poisoning. Meanwhile, hemorheological indexes are good indicators for monitoring the pathological dynamic after acute CO poisoning.

语种英语
WOS记录号WOS:000349693400001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56816
专题北京大学临床肿瘤学院_供应室
北京大学基础医学院
北京大学第三临床医学院_血液内科
北京大学第三临床医学院_职业病科
作者单位1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Guan, Li,Zhang, Yan-Lin,Li, Zong-Yang,et al. Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Guan, Li,Zhang, Yan-Lin,Li, Zong-Yang,Zhu, Ming-Xia,Yao, Wei-Juan,&Zhao, Jin-Yuan.(2015).Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties.BIOMED RESEARCH INTERNATIONAL.
MLA Guan, Li,et al."Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties".BIOMED RESEARCH INTERNATIONAL (2015).
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