北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 职业病科  > 期刊论文
学科主题: 临床医学
题名:
Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties
作者: Guan, Li1; Zhang, Yan-Lin1; Li, Zong-Yang1; Zhu, Ming-Xia1; Yao, Wei-Juan2; Zhao, Jin-Yuan1
刊名: BIOMED RESEARCH INTERNATIONAL
发表日期: 2015
DOI: 10.1155/2015/526483
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]: Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]: CARBON-MONOXIDE INTOXICATION ; HEMORHEOLOGICAL CHANGES ; RBC DEFORMABILITY ; APOPTOSIS ; VISCOSITY ; CELLS ; MICRODIALYSIS ; AGGREGATION ; MECHANISM ; STRIATUM
英文摘要:

Carbon monoxide (CO) poisoning causes the major injury and death due to poisoning worldwide. The most severe damage via CO poisoning is brain injury and mortality. Delayed encephalopathy after acute CO poisoning (DEACMP) occurs in forty percent of the survivors of acute CO exposure. But the pathological cause for DEACMP is not well understood. And the corresponding therapy is not well developed. In order to investigate the effects of salvianolic acid (SA) on brain injury caused by CO exposure from the view point of hemorheology, we employed a rat model and studied the dynamic of blood changes in the hemorheological and coagulative properties over acute CO exposure. Compared with the groups of CO and 20% mannitol + CO treatments, the severe hippocampal injury caused by acute CO exposure was prevented by SA treatment. These protective effects were associated with the retaining level of hematocrit (Hct), plasma viscosity, fibrinogen, whole blood viscosities and malondialdehyde (MDA) levels in red blood cells (RBCs). These results indicated that SA treatment could significantly improve the deformation of erythrocytes and prevent the damage caused by CO poisoning. Meanwhile, hemorheological indexes are good indicators for monitoring the pathological dynamic after acute CO poisoning.

语种: 英语
所属项目编号: 81101024 ; 7113175
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000349693400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56816
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Guan, Li,Zhang, Yan-Lin,Li, Zong-Yang,et al. Salvianolic Acids Attenuate Rat Hippocampal Injury after Acute CO Poisoning by Improving Blood Flow Properties[J]. BIOMED RESEARCH INTERNATIONAL,2015.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Guan, Li]'s Articles
[Zhang, Yan-Lin]'s Articles
[Li, Zong-Yang]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Guan, Li]‘s Articles
[Zhang, Yan-Lin]‘s Articles
[Li, Zong-Yang]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace