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学科主题: 临床医学
题名:
The regulating effect of heme oxygenase/carbon monoxide on hypoxic pulmonary vascular structural remodeling
作者: Shi, Y; Du, JB; Gong, LM; Zeng, CM; Tang, XY; Tang, CS
关键词: carbon monoxide ; heme oxygenase ; hypoxia ; remodeling
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2003-06-27
DOI: 10.1016/S0006-291X(03)00998-7
卷: 306, 期:2, 页:523-529
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: CARBON-MONOXIDE ; EXPRESSION ; HYPERTENSION ; ENDOTHELIN-1 ; MECHANISMS ; APOPTOSIS ; ARTERIES ; RATS ; GENE
英文摘要:

Hypoxic pulmonary vascular structural remodeling (HPVSR) is the important pathologic basis of hypoxic pulmonary hypertension (HPH). The discoveries of endogenous gaseous messenger molecules, nitric oxide (NO) and carbon monoxide (CO), have been moving the research of HPVSR to a very new phase. But the effect and significance of heme oxygenase (HO)/CO on the development of HPVSR have not been fully understood. In this study, we observed the alteration of endogenous HO/CO system in five time points during 14 days and found that the content of CO in lung homogenates in rats with HPVSR increased in a time-dependent double-peak manner. Exogenous supply of ZnPP-IX, an inhibitor of HO-1, decreased the content of CO in lung homogenate, decreased the expression of Fas and apoptotic cells in pulmonary artery smooth muscle cells (PASMCs), up-regulated the expression of PCNA in PASMCs, and worsened HPH and HPVSR of hypoxic rats. Meanwhile, exogenous supply of CO played an adverse action. The results showed that the up-regulation of HO/CO exerted a protective role in the development of HPVSR. (C) 2003 Elsevier Science (USA). All rights reserved.

语种: 英语
WOS记录号: WOS:000183734800032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56818
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ First Hosp, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ First Hosp, Lab Elect Microscopy, Beijing, Peoples R China
4.Peking Univ First Hosp, Cardiovasc Res Inst, Beijing, Peoples R China

Recommended Citation:
Shi, Y,Du, JB,Gong, LM,et al. The regulating effect of heme oxygenase/carbon monoxide on hypoxic pulmonary vascular structural remodeling[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2003,306(2):523-529.
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