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学科主题: 药学
题名:
Stereoselective synthesis of natural N-(1-deoxy-D-beta-fructos-1-yl)-L-amino acids and their effect on lead decorporation
作者: Huo, CX; Wang, C; Zhao, M; Peng, SQ
刊名: CHEMICAL RESEARCH IN TOXICOLOGY
发表日期: 2004-08-01
DOI: 10.1021/tx034223p
卷: 17, 期:8, 页:1112-1120
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Toxicology
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry ; Toxicology
关键词[WOS]: AMADORI REARRANGEMENT ; CHELATING-AGENTS ; CADMIUM ; INTOXICATION ; IDENTIFICATION ; MOBILIZATION ; DERIVATIVES ; PRODUCTS ; RATS
英文摘要:

N-(1-Deoxy-D-fructos-1-yl)-L-amino acids isolated from hog liver are endogenous lead decorporation substances with low toxicity and cell membrane crossing ability. To simulate the effect of the natural N-(1-deoxy-D-fructos-1-yl)-L-amino acids on lead decorporation, a series of the epimerically pure N-(1-deoxy-D-fructos-1-yl)-L-amino acids (6a-ebeta) were synthesized, and their usefulness as antagonists of lead intoxication was investigated. The results suggest that after treatment with 6a-ebeta the liver, kidney, bone, and brain, lead levels of mice were significantly reduced in comparison with the control group. Except for bone and brain lead levels of the mice after chelating treatment with 6dbeta, all of the other tissue lead levels of mice after chelating treatment with 6a-ebeta are significantly lower than those of mice after treatment with DL-penicillamine (p < 0.05). All fecal lead levels of mice after treatment with 6a-ebeta are significantly higher than those of mice after treatment with 0.9% saline (controls) and DL-penicillamine (p < 0.05-0.01). The effects of all chelating agents on urinary excretion of lead in mice are clearly superior to the control (p < 0.05-0.01). The results of the present studies on repeated lead exposure indicated that at tested levels of i.p. injections, the fructose-amino acids were effective antagonists of lead poisoning under the experimental conditions. After treatment with the chelators, the concentration of essential metals in mice did not exhibit change as compared to the control. The effects of the compounds on cadmium decorporation were also investigated, and similar results were observed.

语种: 英语
WOS记录号: WOS:000223412000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56819
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Capital Univ Med Sci, Coll Pharmaceut Sci, Beijing 100054, Peoples R China
2.Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Huo, CX,Wang, C,Zhao, M,et al. Stereoselective synthesis of natural N-(1-deoxy-D-beta-fructos-1-yl)-L-amino acids and their effect on lead decorporation[J]. CHEMICAL RESEARCH IN TOXICOLOGY,2004,17(8):1112-1120.
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