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HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients
Zhao, X-Y1,2; Chang, Y-J1,2; Xu, L-P1,2; Zhang, X-H1,2; Liu, K-Y1,2; Li, D.1,2; Huang, X-J1,2,3
关键词Kir Haploidentical Hsct Cml
刊名BRITISH JOURNAL OF CANCER
2014-09-09
DOI10.1038/bjc.2014.423
111期:6页:1080-1088
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Ministry of Education of China ; Collaborative Innovation Center of Hematology, China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Ministry of Education of China ; Collaborative Innovation Center of Hematology, China
研究领域[WOS]Oncology
关键词[WOS]NATURAL-KILLER-CELLS ; NK CELLS ; IN-VITRO ; MARROW-TRANSPLANTATION ; INHIBITORY RECEPTORS ; MISSING SELF ; RECONSTITUTION ; TOLERANCE ; OUTCOMES ; LIGANDS
英文摘要

Background: Conflicting results have been reported regarding the predicative roles of alloreactive natural killer (NK) cells on the outcomes of transplantation in leukaemia patients.

Methods: We prospectively analysed the human leukocyte antigen (HLA) typing of donor-recipient pairs and the KIR typing of the donors in 97 CML patients to address the predictive roles of NK cells in relapse undergoing T-cell-replete haploidentical transplantation.

Results: Patients with class I ligands for the donor-inhibitory KIR gene exhibited decreased molecular and haematologic relapse rates (P = 0.003 and P = 0.015, respectively). There was a significantly reduced risk of molecular and haematologic relapse in patients with HLA-C1C2 or C2C2 who accepted donors with KIR2DS1 or in patients with HLA-Bw4 who accepted donors with KIR3DS1 (′recipient with relevant KIR ligand for donor-activating KIR′, n = 25), compared with the remaining transplants (n = 72, P = 0.009 and P = 0.009, respectively). In addition, the presence of class I ligand in the recipients of donor-activating KIR contributed to a decreased relapse rate in patients lacking class I ligand in the recipient of donor-inhibitory KIR (P = 0.04 and P = 0.03, respectively).

Conclusions: This study suggests that the presence of class I ligands for the donor-activating or donor-inhibitory KIR gene in the recipient might confer some protection against leukaemic relapse in T-cell-replete haploidentical transplantation.

语种英语
所属项目编号81270644 ; 81230013 ; 2013CB733700 ; 20110001110039
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Ministry of Education of China ; Collaborative Innovation Center of Hematology, China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program) ; Ministry of Education of China ; Collaborative Innovation Center of Hematology, China
WOS记录号WOS:000341910900007
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56822
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
3.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, X-Y,Chang, Y-J,Xu, L-P,et al. HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients[J]. BRITISH JOURNAL OF CANCER,2014,111(6):1080-1088.
APA Zhao, X-Y.,Chang, Y-J.,Xu, L-P.,Zhang, X-H.,Liu, K-Y.,...&Huang, X-J.(2014).HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients.BRITISH JOURNAL OF CANCER,111(6),1080-1088.
MLA Zhao, X-Y,et al."HLA and KIR genotyping correlates with relapse after T-cell-replete haploidentical transplantation in chronic myeloid leukaemia patients".BRITISH JOURNAL OF CANCER 111.6(2014):1080-1088.
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