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学科主题临床医学
A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer
Chen, Jingzhou1; Shi, Yi2,3; Li, Ziyu4; Yu, Hui1; Han, Yu1; Wang, Xiaojian1; Sun, Kai1; Yang, Tao1; Lou, Kejia1; Song, Yan1; Zhang, Yinhui1; Zhen, Yisong1; Zhang, Guiguo4; Hu, Ying4; Ji, Jiafu4; Hui, Rutai1
刊名MOLECULAR MEDICINE
2011-07-01
DOI10.2119/molmed.2010.00192
17期:7-8页:607-618
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Medicine, Research & Experimental
资助者National High Technology Research and Development Program of China (863 Program) ; National Science and Technology Major Projects ; Foundation of Beijing Municipal Committee of Science and Technology ; National High Technology Research and Development Program of China (863 Program) ; National Science and Technology Major Projects ; Foundation of Beijing Municipal Committee of Science and Technology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Research & Experimental Medicine
关键词[WOS]PROTEIN-KINASE B ; CARCINOMA CELLS ; MODIFIER GENES ; POLYMORPHISMS ; MUTATION ; GROWTH ; EXPRESSION ; DIAGNOSIS ; PATHWAY ; CDK5
英文摘要

The IC53 gene was reported to be upregulated in the colon adenocarcinoma cell line SW480. Here, we show that the expression level of IC53 is positively correlated with the grade and depth of invasion in adenocarcinoma of the colon. Injection of IC53 stably transfected HCT-116 cells into athymic nude mice promoted tumor growth. Furthermore, overexpression of IC53 increased cell invasive growth, which could be dramatically prevented by knocking down IC53 with siRNA. The effects of IC53 on cell-invasive growth were mediated by upregulation of integrins, activation of phosphatidylinositol 3-kinase and phosphorylation of Akt. A single-nucleotide polymorphism rs2737 in the IC53 gene created a potential microRNA379 target site, and microRNA379 expression inhibited IC53 translation. Among 222 patients with colorectal cancer, the C/C rs2737 genotype was associated with late onset of colorectal cancer (median age 63.0 versus 55.3 years, P = 0.003). The frequency of the C/C rs2737 genotype was much lower in patients who developed colorectal cancer below the age of 45 years than in individuals over age 45 years (10.8% versus 26.6%, P = 0.039). These data indicated that IC53 is a positive mediator for colon cancer progression, and IC53-rs2737 may serve as protection from the onset of colorectal cancer. (C) 2011 The Feinstein Institute for Medical Research, www.feinsteininstitute.org

语种英语
所属项目编号2006AA02Z477 ; 2009ZX09501-026 ; D0905001040631
资助者National High Technology Research and Development Program of China (863 Program) ; National Science and Technology Major Projects ; Foundation of Beijing Municipal Committee of Science and Technology ; National High Technology Research and Development Program of China (863 Program) ; National Science and Technology Major Projects ; Foundation of Beijing Municipal Committee of Science and Technology
WOS记录号WOS:000293681600004
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56828
专题北京大学临床肿瘤学院_肿瘤外科
作者单位1.Sichuan Prov Peoples Hosp, Chengdu, Peoples R China
2.Chinese Acad Med Sci, Fuwai Hosp, Minist Educ,Peking Union Med Coll, Key Lab Clin Cardiovasc Genet,Sino German Lab Mol, Beijing 100037, Peoples R China
3.Sichuan Acad Med Sci, Sichuan Prov Key Lab Human Dis Gene Study, Chengdu, Peoples R China
4.Peking Univ Canc Hosp & Inst, Minist Educ, Key Lab Carcinogenesis & Translat Res, Dept Surg, Beijing 100042, Peoples R China
推荐引用方式
GB/T 7714
Chen, Jingzhou,Shi, Yi,Li, Ziyu,et al. A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer[J]. MOLECULAR MEDICINE,2011,17(7-8):607-618.
APA Chen, Jingzhou.,Shi, Yi.,Li, Ziyu.,Yu, Hui.,Han, Yu.,...&Hui, Rutai.(2011).A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer.MOLECULAR MEDICINE,17(7-8),607-618.
MLA Chen, Jingzhou,et al."A Functional Variant of IC53 Correlates with the Late Onset of Colorectal Cancer".MOLECULAR MEDICINE 17.7-8(2011):607-618.
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