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学科主题: 临床医学
题名:
BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults
作者: Li, Shengxu1; Xiao, Jianzhong2; Ji, Linong3; Weng, Jianping4; Jia, Weiping5; Lu, Juming6; Zhou, Zhiguang7; Guo, Xiaohui8; Liu, Jie9; Shan, Zhongyan10; Zhu, Dalong11; Chen, Li12; Zhao, Zhigang13; Tian, Haoming14; Ji, Qiuhe15; Ge, Jiapu16; Li, Qiang17; Lin, Lixiang18; Yang, Zhaojun2; He, Jiang1; Yang, Wenying2; China Natl Diabet Metab Disorders
关键词: Glucose metabolism ; Type 2 diabetes ; BMI ; Waist circumference ; China
刊名: JOURNAL OF DIABETES AND ITS COMPLICATIONS
发表日期: 2014-07-01
DOI: 10.1016/j.jdiacomp.2014.03.015
卷: 28, 期:4, 页:470-476
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: BODY-MASS INDEX ; TO-HIP RATIO ; ABDOMINAL OBESITY ; INSULIN-RESISTANCE ; FAT DISTRIBUTION ; RISK-FACTORS ; PREVALENCE ; POPULATION ; MELLITUS ; WOMEN
英文摘要:

Aims: To examine the associations of BMI and waist circumference with glucose metabolism and (pre) diabetes among adults with BMI < 25 kg/m(2).

Methods: We conducted a cross-sectional study in a nationally representative sample (10,098 men and 17,454 women) of Chinese adults aged >= 20 years with BMI < 25 kg/m(2). Glucose levels after at least 10 hours of overnight fasting, at 30 minutes and at 120 minutes after a standard 75-g oral glucose load were measured. Associations of BMI and waist circumference with outcomes were examined by general linear models for continuous outcomes and by logistic regression models for dichotomous outcomes.

Results: Among those with BMI < 25 kg/m(2), 18.8% of men and 17.1% of women had abnormal glucose metabolism, including 4.9% of men and 3.8% of women with undiagnosed type 2 diabetes. For each SD increase in BMI (2.1 kg/m(2)) and waist circumference (8.3 cm), fasting glucose levels increased by 0.128 and 0.170 mmol/L in men, and by 0.112 and 0.167 mmol/L in women, respectively; the corresponding increases for 2-hour post-load glucose levels were 0.121 and 0.217 mmol/L in men, and 0.241 and 0.362 mmol/L in women. When simultaneously included in the same model, these associations with waist circumference were stronger than with BMI.

Conclusion: Obesity measures are associated with abnormal glucose metabolism and diabetes, with central obesity playing a more prominent role than general obesity in Chinese population with BMI < 25 kg/m(2). Chinese diabetes prevention and treatment programs should incorporate targeting of normal weight adults with central obesity.

语种: 英语
项目资助者: Chinese Medical Association Foundation ; Chinese Diabetes Society
WOS记录号: WOS:000338799600008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56829
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.China Japan Friendship Hosp, Beijing, Peoples R China
2.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
3.Chinese PIA Gen Hosp, Beijing, Peoples R China
4.Xiangya Second Hosp, Xiangya, Hunan, Peoples R China
5.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China
6.Xinjiang Uygur Autonomous Reg Hosp, Xinjiang, Peoples R China
7.Fujian Prov Hosp, Fuzhou, Fujian, Peoples R China
8.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
9.Shanxi Prov Peoples Hosp, Taiyuan, Shanxi, Peoples R China
10.Shandong Univ, Qilu Hosp, Jinan, Shandong, Peoples R China
11.Tulane Sch Publ Hlth & Trop Med, Dept Epidemiol, New Orleans, LA USA
12.Sun Yat Sen Univ, Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
13.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200030, Peoples R China
14.Chinese Med Univ, Affiliated Hosp 1, Liaoning, Peoples R China
15.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China
16.Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China
17.Fourth Mil Med Univ, Xijing Hosp, Xian, Shaanxi, Peoples R China
18.Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China

Recommended Citation:
Li, Shengxu,Xiao, Jianzhong,Ji, Linong,et al. BMI and waist circumference are associated with impaired glucose metabolism and type 2 diabetes in normal weight Chinese adults[J]. JOURNAL OF DIABETES AND ITS COMPLICATIONS,2014,28(4):470-476.
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