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学科主题: 临床医学
题名:
Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China
作者: Huang, Jing1,2,3,4; Han, Sha-sha1,2,3,4; Qin, Dan-dan5; Wu, Li-hua6; Song, Yan7; Yu, Feng1,2,3,4; Wang, Su-xia1,2,3,4; Liu, Gang1,2,3,4; Zhao, Ming-hui1,2,3,4,8
刊名: PLoS One
发表日期: 2015-11-06
DOI: 10.1371/journal.pone.0141547
卷: 10, 期:11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: VASCULAR-LESIONS ; AMERICAN-COLLEGE ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; ATHEROSCLEROSIS ; MORTALITY ; CYCLOPHOSPHAMIDE ; ASSOCIATION ; GLOMERULONEPHRITIS ; CLASSIFICATION
英文摘要:

Objective

The aim of this study was to evaluate renal arteriosclerotic lesions in patients with lupus nephritis and investigate their associations with clinical and pathological characteristics, especially cardio-vascular features.

Design

A retrospective cohort study.

Participants

Seventy-nine patients with renal biopsy-proven lupus nephritis, diagnosed between January 2000 and June 2008 from Peking University First Hospital.

Results

In clinico-pathological data, patients with arteriosclerosis had higher ratio of hypertension and more severe renal injury indices compared with patients with no renal vascular lesions. More importantly, patients with renal arteriosclerosis had worse cardiac structure and function under transthoracic echocardiographic examination. Patients with renal arteriosclerosis tend to have higher ratios of combined endpoints compared with those of no renal vascular lesions, although the difference didn′t reach statistical meanings (P = 0.104).

Conclusion

Renal arteriosclerotic lesion was common and associated with vascular immune complex deposits in lupus nephritis. It might have a certain degree of association with poor outcomes and cardiovascular events, which needs further explorations.

语种: 英语
所属项目编号: 2012CB517702 ; 81321064 ; 81470932
项目资助者: Chinese 973 project ; National Natural Science Foundation of China
WOS记录号: WOS:000364398700033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56830
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: 1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
6.Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin 150000, Heilongjiang, Peoples R China
7.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Yinchuan 750004, Ningxia, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Nephrol, Beijing 100048, Peoples R China

Recommended Citation:
Huang, Jing,Han, Sha-sha,Qin, Dan-dan,et al. Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China[J]. PLoS One,2015,10(11).
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