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学科主题临床医学
Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China
Huang, Jing1,2,3,4; Han, Sha-sha1,2,3,4; Qin, Dan-dan5; Wu, Li-hua6; Song, Yan7; Yu, Feng1,2,3,4; Wang, Su-xia1,2,3,4; Liu, Gang1,2,3,4; Zhao, Ming-hui1,2,3,4,8
刊名PLoS One
2015-11-06
DOI10.1371/journal.pone.0141547
10期:11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]VASCULAR-LESIONS ; AMERICAN-COLLEGE ; DISEASE-ACTIVITY ; ERYTHEMATOSUS ; ATHEROSCLEROSIS ; MORTALITY ; CYCLOPHOSPHAMIDE ; ASSOCIATION ; GLOMERULONEPHRITIS ; CLASSIFICATION
英文摘要

Objective

The aim of this study was to evaluate renal arteriosclerotic lesions in patients with lupus nephritis and investigate their associations with clinical and pathological characteristics, especially cardio-vascular features.

Design

A retrospective cohort study.

Participants

Seventy-nine patients with renal biopsy-proven lupus nephritis, diagnosed between January 2000 and June 2008 from Peking University First Hospital.

Results

In clinico-pathological data, patients with arteriosclerosis had higher ratio of hypertension and more severe renal injury indices compared with patients with no renal vascular lesions. More importantly, patients with renal arteriosclerosis had worse cardiac structure and function under transthoracic echocardiographic examination. Patients with renal arteriosclerosis tend to have higher ratios of combined endpoints compared with those of no renal vascular lesions, although the difference didn′t reach statistical meanings (P = 0.104).

Conclusion

Renal arteriosclerotic lesion was common and associated with vascular immune complex deposits in lupus nephritis. It might have a certain degree of association with poor outcomes and cardiovascular events, which needs further explorations.

语种英语
WOS记录号WOS:000364398700033
项目编号2012CB517702 ; 81321064 ; 81470932
资助机构Chinese 973 project ; National Natural Science Foundation of China
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56830
专题北京大学第一临床医学院_肾脏内科
北京大学第一临床医学院_电镜室
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
3.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
5.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
6.Harbin Med Univ, Affiliated Hosp 2, Dept Nephrol, Harbin 150000, Heilongjiang, Peoples R China
7.Ningxia Med Univ, Gen Hosp, Dept Nephrol, Yinchuan 750004, Ningxia, Peoples R China
8.Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Nephrol, Beijing 100048, Peoples R China
推荐引用方式
GB/T 7714
Huang, Jing,Han, Sha-sha,Qin, Dan-dan,et al. Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China[J]. PLoS One,2015,10(11).
APA Huang, Jing.,Han, Sha-sha.,Qin, Dan-dan.,Wu, Li-hua.,Song, Yan.,...&Zhao, Ming-hui.(2015).Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China.PLoS One,10(11).
MLA Huang, Jing,et al."Renal Interstitial Arteriosclerotic Lesions in Lupus Nephritis Patients: A Cohort Study from China".PLoS One 10.11(2015).
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