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学科主题: 基础医学
题名:
Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated
作者: Huang, Cheng1,2; Huang, Zhi-Qin3; Hu, Zhi-Ping1; Jiang, Shao-Zu1; Li, Han-Ting1; Han, Ji-Sheng2; Wan, You2
关键词: electroacupuncture ; antinociception ; complete Freund&prime ; s adjuvant ; inflammatory pain ; tolerance ; naloxone
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9721-x
卷: 33, 期:10, 页:2107-2111
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: MORPHINE-TOLERANCE ; OPIOID SYSTEMS ; ARTHRITIC RATS ; ANALGESIA ; ACUPUNCTURE ; STIMULATION ; INVOLVEMENT ; RELEASE ; OPIATE
英文摘要:

We have previously shown that electroacupuncture (EA) produced antinociception through the release of endogenous opioid peptides to activate opioid receptors during acute nociception. EA produced tolerance after its prolonged application. It has reported that 100 Hz EA could reduce mechanical hyperalgesia in complete Freund′s adjuvant (CFA)-induced inflammatory nociception rats. The present study aims to investigate the antinociceptive effect of EA and the development of EA tolerance in chronic inflammatory nociception rats with CFA injection into the hind paw plantar. The results showed that the antinociceptive effect of 100 Hz EA was significantly enhanced in CFA-induced inflammatory nociception rats. Naloxone at 20 mg/kg could significantly block this antinociceptive effect. Chronic tolerance to EA was developed faster in CFA-induced inflammatory nociception rats than in normal rats. Therefore, 100 Hz EA could enhance antinociceptive effects and accelerate tolerance development in CFA-induced inflammatory nociception rats. The enhancement of EA antinociceptive effect in CFA-induced inflammatory nociception rats might involve the endogenous opioid peptides such as dynorphin.

语种: 英语
所属项目编号: 30560145 ; 30600173 ; 30570566 ; 2007CB512501
项目资助者: National Natural Science Foundation of China ; Ministry of Education of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000259190900026
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56831
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Gannan Med Univ, Dept Physiol, Ganzhou 341000, Jiangxi, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
3.Gannan Med Univ, Dept Pharm, Ganzhou 341000, Jiangxi, Peoples R China

Recommended Citation:
Huang, Cheng,Huang, Zhi-Qin,Hu, Zhi-Ping,et al. Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2107-2111.
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