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学科主题基础医学
Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated
Huang, Cheng1,2; Huang, Zhi-Qin3; Hu, Zhi-Ping1; Jiang, Shao-Zu1; Li, Han-Ting1; Han, Ji-Sheng2; Wan, You2
关键词Electroacupuncture Antinociception Complete Freund&Prime s Adjuvant Inflammatory Pain Tolerance Naloxone
刊名NEUROCHEMICAL RESEARCH
2008-10-01
DOI10.1007/s11064-008-9721-x
33期:10页:2107-2111
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]MORPHINE-TOLERANCE ; OPIOID SYSTEMS ; ARTHRITIC RATS ; ANALGESIA ; ACUPUNCTURE ; STIMULATION ; INVOLVEMENT ; RELEASE ; OPIATE
英文摘要

We have previously shown that electroacupuncture (EA) produced antinociception through the release of endogenous opioid peptides to activate opioid receptors during acute nociception. EA produced tolerance after its prolonged application. It has reported that 100 Hz EA could reduce mechanical hyperalgesia in complete Freund′s adjuvant (CFA)-induced inflammatory nociception rats. The present study aims to investigate the antinociceptive effect of EA and the development of EA tolerance in chronic inflammatory nociception rats with CFA injection into the hind paw plantar. The results showed that the antinociceptive effect of 100 Hz EA was significantly enhanced in CFA-induced inflammatory nociception rats. Naloxone at 20 mg/kg could significantly block this antinociceptive effect. Chronic tolerance to EA was developed faster in CFA-induced inflammatory nociception rats than in normal rats. Therefore, 100 Hz EA could enhance antinociceptive effects and accelerate tolerance development in CFA-induced inflammatory nociception rats. The enhancement of EA antinociceptive effect in CFA-induced inflammatory nociception rats might involve the endogenous opioid peptides such as dynorphin.

语种英语
WOS记录号WOS:000259190900026
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56831
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Gannan Med Univ, Dept Physiol, Ganzhou 341000, Jiangxi, Peoples R China
2.Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
3.Gannan Med Univ, Dept Pharm, Ganzhou 341000, Jiangxi, Peoples R China
推荐引用方式
GB/T 7714
Huang, Cheng,Huang, Zhi-Qin,Hu, Zhi-Ping,等. Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2107-2111.
APA Huang, Cheng.,Huang, Zhi-Qin.,Hu, Zhi-Ping.,Jiang, Shao-Zu.,Li, Han-Ting.,...&Wan, You.(2008).Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated.NEUROCHEMICAL RESEARCH,33(10),2107-2111.
MLA Huang, Cheng,et al."Electroacupuncture effects in a rat model of complete Freund′s adjuvant-induced inflammatory pain: Antinociceptive effects enhanced and tolerance development accelerated".NEUROCHEMICAL RESEARCH 33.10(2008):2107-2111.
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