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Synthesis and biological evaluation of a novel class of coumarin derivatives
Li, Hong1; Wang, Xiaomin2; Xu, Guichao1; Zeng, Li1; Cheng, Kai1; Gao, Pengchao3; Sun, Qing1; Liao, Wei1; Zhang, Jianwei1
关键词Amino Acid Coumarin Peptide Anti-tumor Cytotoxicity
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2014-11-15
DOI10.1016/j.bmcl.2014.09.051
24期:22页:5274-5278
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]ACTIVATED PROTEIN-KINASE ; MALIGNANT MELANOMA-CELLS ; IN-VITRO ; ACID ; DNA ; COMPLEXES ; ANTITUMOR ; BINDING ; PEPT1
英文摘要

In this study, several novel coumarin derivatives, 7-hydroxy-2-oxo-2H-chromene-3-carboxyl-Trp-Trp-AA-OBzl compounds, were designed and synthesized as potential anticancer agents. Their in vitro cytotoxic activities were evaluated using methylthiazoltetrazolium (MTT) assay. The anti-tumor activity of the newly coumarin derivatives was determined in a S180 bearing mouse model and some of the compounds demonstrated tumor growth inhibition similar to the positive control, doxorubicin. Compared to doxorubicin, most of the compounds exhibited enhanced immunologic function suggesting a relatively minor toxic effect. The intercalation of the coumarin derivatives synthesized with calf thymus (CT) DNA was also studied. (C) 2014 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000343901400029
项目编号PHR201007114 ; 2011CB504100 ; 81030062 ; 2011ZX09102-003-01 ; 2013BI-01
资助机构Academic Human Resources Development in Institutions of Higher Learning Under the Jurisdiction of Beijing Municipality ; National Basic Research Program of China ; National Natural Scientific Foundation of China ; Key National Science &amp ; Technology Specific Projects ; Beijing Pharmacological Society
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56836
专题北京大学药学院
作者单位1.Capital Med Univ, Coll Pharmaceut Sci, Beijing 100069, Peoples R China
2.Capital Med Univ, Minist Educ, Key Lab Neurodegenerat Disorders, Dept Physiol, Beijing 100069, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Li, Hong,Wang, Xiaomin,Xu, Guichao,et al. Synthesis and biological evaluation of a novel class of coumarin derivatives[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2014,24(22):5274-5278.
APA Li, Hong.,Wang, Xiaomin.,Xu, Guichao.,Zeng, Li.,Cheng, Kai.,...&Zhang, Jianwei.(2014).Synthesis and biological evaluation of a novel class of coumarin derivatives.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,24(22),5274-5278.
MLA Li, Hong,et al."Synthesis and biological evaluation of a novel class of coumarin derivatives".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24.22(2014):5274-5278.
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