北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
Application of GFR-estimating equations in Chinese patients with chronic kidney disease
作者: Zuo, L; Ma, YC; Zhou, YH; Wang, M; Xu, GB; Wang, HY
关键词: chronic kidney disease (CKD) ; glomerular filtration rate (GFR) ; Modification of Diet in Renal Disease (MDRD) equation ; Cockcroft-Gault equation ; prediction equation
刊名: AMERICAN JOURNAL OF KIDNEY DISEASES
发表日期: 2005-03-01
DOI: 10.1053/j.ajkd.2004.11.012
卷: 45, 期:3, 页:463-472
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: GLOMERULAR-FILTRATION-RATE ; CHRONIC RENAL-INSUFFICIENCY ; SERUM CREATININE ASSAY ; PREDICTION EQUATION ; COCKCROFT-GAULT ; CYSTATIN-C ; CLEARANCE ; DIET ; FORMULAS ; MDRD
英文摘要:

Background: To evaluate whether the Modification of Diet in Renal Disease (MDRD) equations could be applied accurately to Chinese patients with chronic kidney disease (CKD), glomerular filtration rates (GFRs) estimated by using MDRD equation 7 (7GFR), the abbreviated MDRD equation (aGFR), and the Cockcroft-Gault equation (cGFR) were compared in patients with different stages of CKD. Methods: The study enrolled patients with CKD diagnosed according to the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative guidelines. All patients were older than 18 years and without acute renal function deterioration, edema, skeletal muscle atrophy, or amputation. Sex, age, body height, and body weight were recorded, and plasma creatinine levels were measured by means of Jaffe′s kinetic method using a Hitachi 7600 analyzer (Hitachi, Tokyo, Japan; reagents from Roche Diagnostics, Mannheim, Germany). Creatinine, urea, and albumin were measured in a single clinical laboratory. Dual plasma sampling of technetium Tc 99m-labeled diethylene triamine pentaacetic acid plasma clearance was used as the reference standard GFR (sGFR) for comparison of 7GFRs, aGFRs, and cGFRs at different stages of CKD. Results: The study enrolled 261 patients, including 146 men and 115 women. Causes of CKD included primary or secondary glomerular disease, obstructive kidney disease, chronic tubulointerstitial disease, and others. Values for 7GFR, aGFR, and cGFR were significantly greater than for sGFR in patients with CKD stages 4 to 5 (the lower the sGFR, the greater the difference); whereas 7GFR, aGFR, and cGFR were significantly lower than sGFR in patients with CKD stage 1. Conclusion: Our results show that in a Chinese population with CKD, MDRD equation 7 and the abbreviated MDRD equation overestimated GFR in patients with CKD stages 4 to 5 and underestimated GFR in those with CKD stage 1. These results indicate that careful modification of these equations may be necessary in Chinese populations with CKD.

语种: 英语
WOS记录号: WOS:000227873000003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56840
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Hosp 1, Div Nephrol, Beijing 100034, Peoples R China
3.Peking Univ, Hosp 1, Dept Clin Lab, Beijing 100034, Peoples R China

Recommended Citation:
Zuo, L,Ma, YC,Zhou, YH,et al. Application of GFR-estimating equations in Chinese patients with chronic kidney disease[J]. AMERICAN JOURNAL OF KIDNEY DISEASES,2005,45(3):463-472.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zuo, L]'s Articles
[Ma, YC]'s Articles
[Zhou, YH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zuo, L]‘s Articles
[Ma, YC]‘s Articles
[Zhou, YH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace