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学科主题: 基础医学
题名:
Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats
作者: Chen, JH; Liang, J; Wang, GB; Han, JS; Cui, CL
关键词: peripheral electrical stimulation (PES) ; conditioned place preference (CPP) ; rewarding effect ; spatial learning and memory
刊名: EXPERIMENTAL NEUROLOGY
发表日期: 2005-08-01
DOI: 10.1016/j.expneurol.2005.04.001
卷: 194, 期:2, 页:550-556
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CONDITIONED PLACE PREFERENCE ; PROBABLE ALZHEIMERS-DISEASE ; NERVE-STIMULATION ; DIFFERENT FREQUENCIES ; ABSTINENCE SYNDROME ; AFFECTIVE BEHAVIOR ; OPIOID-RECEPTORS ; C-FOS ; ELECTROACUPUNCTURE ; ACUPUNCTURE
英文摘要:

Our previous studies have shown that 2 Hz peripheral electrical stimulation (PES) can suppress morphine-induced conditioned place preference (CPP) in the rat, although the mechanisms remain unclear. Since CPP involves the mechanism of learning and memory, it is rational to ask whether the suppressive effect of repeated 2 Hz PES on morphine-induced CPP is due to an impairment of the function of spatial learning and memory. Rats were trained with 4 mg/kg morphine, i.p. for 4 days to establish the CPP. Twenty-four hours after the CPP testing, they were given PES at 2 Hz once a day for 1, 3 or 5 days, followed by another CPP testing. The results showed that (1) the morphine-induced CPP was significantly inhibited by 3 or 5 consecutive sessions, but not by single session of 2 Hz PES. (2) A test of spatial leaning and memory ability using the Morris water maze task revealed that 2 Hz PES per se exhibited a promoting, rather than a deteriorating effect on the ability of spatial memory. (3) 2 Hz PES by itself produced a moderate yet significant CPP. The results imply that (a) a low frequency PES can produce a rewarding effect as revealed by the CPP testing, which may account, at least in part, for its suppressive effect on morphine induced UP, (b) the suppressive effect of PES on morphine induced CPP is not due to a deteriorating effect on the ability of spatial memory. (c) 2005 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000230876100023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56861
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Chen, JH,Liang, J,Wang, GB,et al. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats[J]. EXPERIMENTAL NEUROLOGY,2005,194(2):550-556.
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