IR@PKUHSC  > 基础医学院  > 神经生物学系
学科主题基础医学
Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats
Chen, JH; Liang, J; Wang, GB; Han, JS; Cui, CL
关键词peripheral electrical stimulation (PES) conditioned place preference (CPP) rewarding effect spatial learning and memory
刊名EXPERIMENTAL NEUROLOGY
2005-08-01
DOI10.1016/j.expneurol.2005.04.001
194期:2页:550-556
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CONDITIONED PLACE PREFERENCE ; PROBABLE ALZHEIMERS-DISEASE ; NERVE-STIMULATION ; DIFFERENT FREQUENCIES ; ABSTINENCE SYNDROME ; AFFECTIVE BEHAVIOR ; OPIOID-RECEPTORS ; C-FOS ; ELECTROACUPUNCTURE ; ACUPUNCTURE
英文摘要

Our previous studies have shown that 2 Hz peripheral electrical stimulation (PES) can suppress morphine-induced conditioned place preference (CPP) in the rat, although the mechanisms remain unclear. Since CPP involves the mechanism of learning and memory, it is rational to ask whether the suppressive effect of repeated 2 Hz PES on morphine-induced CPP is due to an impairment of the function of spatial learning and memory. Rats were trained with 4 mg/kg morphine, i.p. for 4 days to establish the CPP. Twenty-four hours after the CPP testing, they were given PES at 2 Hz once a day for 1, 3 or 5 days, followed by another CPP testing. The results showed that (1) the morphine-induced CPP was significantly inhibited by 3 or 5 consecutive sessions, but not by single session of 2 Hz PES. (2) A test of spatial leaning and memory ability using the Morris water maze task revealed that 2 Hz PES per se exhibited a promoting, rather than a deteriorating effect on the ability of spatial memory. (3) 2 Hz PES by itself produced a moderate yet significant CPP. The results imply that (a) a low frequency PES can produce a rewarding effect as revealed by the CPP testing, which may account, at least in part, for its suppressive effect on morphine induced UP, (b) the suppressive effect of PES on morphine induced CPP is not due to a deteriorating effect on the ability of spatial memory. (c) 2005 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000230876100023
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56861
专题基础医学院_神经生物学系
作者单位Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Chen, JH,Liang, J,Wang, GB,et al. Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats[J]. EXPERIMENTAL NEUROLOGY,2005,194(2):550-556.
APA Chen, JH,Liang, J,Wang, GB,Han, JS,&Cui, CL.(2005).Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats.EXPERIMENTAL NEUROLOGY,194(2),550-556.
MLA Chen, JH,et al."Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats".EXPERIMENTAL NEUROLOGY 194.2(2005):550-556.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Repeated 2 Hz periph(317KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, JH]的文章
[Liang, J]的文章
[Wang, GB]的文章
百度学术
百度学术中相似的文章
[Chen, JH]的文章
[Liang, J]的文章
[Wang, GB]的文章
必应学术
必应学术中相似的文章
[Chen, JH]的文章
[Liang, J]的文章
[Wang, GB]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Repeated 2 Hz peripheral electrical stimulations suppress morphine-induced CPP and improve spatial memory ability in rats.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。