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学科主题: 临床医学
题名:
A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population
作者: Zeng, Zheng2; Guan, Li1; An, Ping1; Sun, Shan3; O′ Brien, Stephen J.1; Winkler, Cheryl A.1; HBV Study Consortium
刊名: BMC INFECTIOUS DISEASES
发表日期: 2008-01-02
DOI: 10.1186/1471-2334-8-1
卷: 8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: HEPATOCELLULAR-CARCINOMA RISK ; REPUBLIC-OF-CHINA ; VIRUS INFECTION ; FULMINANT-HEPATITIS ; LIVER-DISEASE ; CORE PROMOTER ; AFLATOXIN EXPOSURE ; UNITED-STATES ; RECEPTOR GENE ; FOLLOW-UP
英文摘要:

Background: Hepatitis B virus (HBV) infection is a significant public health problem that may lead to chronic liver disease, cirrhosis, and hepatocellular carcinoma (HCC). Approximately 30% of the world′s population has been infected with HBV and approximately 350 million (5 - 6%) are persistent carriers. More than 120 million Chinese are infected with HBV. The role of host genetic factors and their interactions with environmental factors leading to chronic HBV infection and its complications are not well understood. We believe that a better understanding of these factors and interactions will lead to more effective diagnostic and therapeutic options.

Methods/Design: This is a population-based, case-control study protocol to enroll 2200 Han Chinese from medical centers in northern and western China. Adult subjects in the following groups are being enrolled: healthy donors (n = 200), HBV infected persons achieving virus clearance (n = 400), asymptomatic HBV persistent carriers (n = 400), chronic hepatitis B cases (n = 400), decompensated liver cirrhosis with HBV infection cases (n = 400), and hepatocellular carcinoma with HBV infection cases (n = 400). In addition, for haplotype inference and quality control of sample handling and genotyping results, children of 1000 cases will be asked to provide a buccal sample for DNA extraction. With the exception of adult patients presenting with liver cirrhosis or HCC, all other cases and controls will be 40 years or older at enrollment. A questionnaire is being administered to capture dietary and environmental risk factors. Both candidate-gene and genome-wide association approaches will be used to assess the role of single genetic factors and higher order interactions with other genetic or environmental factors in HBV diseases.

Conclusion: This study is designed and powered to detect single gene effects as well as gene-gene and environmental-gene interactions. The identification of allelic polymorphisms in genes involved in the pathway leading to chronic viral infection, liver cirrhosis and, ultimately, hepatocellular carcinoma would provide insights to those factors leading to HBV replication, liver inflammation, fibrosis, and the carcinogenic process. An understanding of the contribution of host genetic factors and their interactions may inform public health policy, improve diagnostics and clinical management, and provide targets for drug development.

语种: 英语
WOS记录号: WOS:000253142400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56862
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Conservat Int China Program, Beijing, Peoples R China
2.Natl Canc Inst, SAIC, Lab Genom Divers, NIH, Frederick, MD USA
3.Peking Univ, Hosp 1, Dept Infect Dis, Beijing 100871, Peoples R China

Recommended Citation:
Zeng, Zheng,Guan, Li,An, Ping,et al. A population-based study to investigate host genetic factors associated with hepatitis B infection and pathogenesis in the Chinese population[J]. BMC INFECTIOUS DISEASES,2008,8.
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