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学科主题: 精神卫生
题名:
Systematic association analysis of microRNA machinery genes with schizophrenia informs further study
作者: Zhang, Fuquan1,2; Chen, Yaguang1,2; Liu, Chenxing1,2; Lu, Tianlan1,2; Yan, Hao1,2; Ruan, Yanyan1,2; Yue, Weihua1,2; Wang, Lifang1,2; Zhang, Dai1,2
关键词: Schizophrenia ; microRNA ; EIF4ENIF1 ; PIWIL2 ; DGCR8
刊名: NEUROSCIENCE LETTERS
发表日期: 2012-06-27
DOI: 10.1016/j.neulet.2012.05.028
卷: 520, 期:1, 页:47-50
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: GENOME-WIDE ASSOCIATION ; RENAL-CELL CARCINOMA ; PREFRONTAL CORTEX ; EXPRESSION ; INDIVIDUALS ; BIOGENESIS ; EIF4E ; POLYMORPHISMS ; DISORDERS ; SURVIVAL
英文摘要:

microRNAs (miRNAs) play a vital role in development via the post-transcriptional regulation of most genes. Variation in the miRNA machinery pathway proteins which mediate the biogenesis, maturation, transportation, and functioning of miRNAs might be relevant to human traits. In this work, we explored the role of 59 miRNA machinery genes in schizophrenia (SZ). Association analysis of 967 single nucleotide polymorphisms within these genes detected that an intronic polymorphism of EIF4ENIF1, rs7289941, was significantly associated with SZ (P = 4.10E-5). We failed to replicate this result in a validation sample comprising 1027 healthy controls and 1012 SZ cases, and the combined data yielded nominal significance (P = 0.013). We conducted a gene-based association analysis using VEGAS and SKAT, and found seven associated genes in total, including EIF4ENIF1, PIWIL2, and DGCR8, but none survived correction for multiple testing. Taken together, our data do not provide strong support for the association of common variants within miRNA machinery genes with SZ in the Han Chinese population, but implicate several promising candidate genes for further research. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 2009AA022702 ; 81000578 ; 81071087 ; 81071088 ; 2011CB707805 ; 2010DFB30820
项目资助者: National High-Tech Research and Development Program of China ; National Natural Science Foundation of China ; National Basic Research Program of China ; International Science &amp ; Technology Cooperation Program of China
WOS记录号: WOS:000306027300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56864
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Fuquan,Chen, Yaguang,Liu, Chenxing,et al. Systematic association analysis of microRNA machinery genes with schizophrenia informs further study[J]. NEUROSCIENCE LETTERS,2012,520(1):47-50.
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