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Systematic association analysis of microRNA machinery genes with schizophrenia informs further study
Zhang, Fuquan1,2; Chen, Yaguang1,2; Liu, Chenxing1,2; Lu, Tianlan1,2; Yan, Hao1,2; Ruan, Yanyan1,2; Yue, Weihua1,2; Wang, Lifang1,2; Zhang, Dai1,2
关键词Schizophrenia Microrna Eif4enif1 Piwil2 Dgcr8
刊名NEUROSCIENCE LETTERS
2012-06-27
DOI10.1016/j.neulet.2012.05.028
520期:1页:47-50
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GENOME-WIDE ASSOCIATION ; RENAL-CELL CARCINOMA ; PREFRONTAL CORTEX ; EXPRESSION ; INDIVIDUALS ; BIOGENESIS ; EIF4E ; POLYMORPHISMS ; DISORDERS ; SURVIVAL
英文摘要

microRNAs (miRNAs) play a vital role in development via the post-transcriptional regulation of most genes. Variation in the miRNA machinery pathway proteins which mediate the biogenesis, maturation, transportation, and functioning of miRNAs might be relevant to human traits. In this work, we explored the role of 59 miRNA machinery genes in schizophrenia (SZ). Association analysis of 967 single nucleotide polymorphisms within these genes detected that an intronic polymorphism of EIF4ENIF1, rs7289941, was significantly associated with SZ (P = 4.10E-5). We failed to replicate this result in a validation sample comprising 1027 healthy controls and 1012 SZ cases, and the combined data yielded nominal significance (P = 0.013). We conducted a gene-based association analysis using VEGAS and SKAT, and found seven associated genes in total, including EIF4ENIF1, PIWIL2, and DGCR8, but none survived correction for multiple testing. Taken together, our data do not provide strong support for the association of common variants within miRNA machinery genes with SZ in the Han Chinese population, but implicate several promising candidate genes for further research. (c) 2012 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000306027300010
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56864
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
北京大学精神卫生研究所_生化室
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
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GB/T 7714
Zhang, Fuquan,Chen, Yaguang,Liu, Chenxing,et al. Systematic association analysis of microRNA machinery genes with schizophrenia informs further study[J]. NEUROSCIENCE LETTERS,2012,520(1):47-50.
APA Zhang, Fuquan.,Chen, Yaguang.,Liu, Chenxing.,Lu, Tianlan.,Yan, Hao.,...&Zhang, Dai.(2012).Systematic association analysis of microRNA machinery genes with schizophrenia informs further study.NEUROSCIENCE LETTERS,520(1),47-50.
MLA Zhang, Fuquan,et al."Systematic association analysis of microRNA machinery genes with schizophrenia informs further study".NEUROSCIENCE LETTERS 520.1(2012):47-50.
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