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Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
Zhang, XY; Tan, YL; Cao, LY; Wu, GY; Xu, Q; Shen, Y; Zhou, DF
关键词Schizophrenia Oxidative Stress Antioxidant Enzymes Lipid Peroxidation Antipsychotics Psychopathology Free Radicals
刊名SCHIZOPHRENIA RESEARCH
2006-01-31
DOI10.1016/j.schres.2005.10.011
81期:2-3页:291-300
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]BLOOD SUPEROXIDE-DISMUTASE ; FREE-RADICAL PATHOLOGY ; ESSENTIAL FATTY-ACIDS ; TARDIVE-DYSKINESIA ; GLUTATHIONE-PEROXIDASE ; THERAPEUTIC IMPLICATIONS ; DEFENSE SYSTEM ; GINKGO-BILOBA ; PLASMA ; HALOPERIDOL
英文摘要

There is accumulating evidence of altered antioxidant enzyme activities and increased levels of lipid peroxidation in schizophrenia. Free radical-mediated abnormalities may contribute to specific aspects of schizophrenic symptomatology and complications of its treatment. However, few studies have evaluated both antioxidant enzymes and lipid peroxidation in the same schizophrenic patient groups treated with typical or atypical antipsychotics. Plasma malondialdehyde (NIDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities were analyzed using established procedures in 92 medicated schizophrenia including paranoid (n=34), disorganized (n=18) and residual subtypes (n=40), as well as in control subjects (n=50). The results showed that activities of SOD and GSH-Px were decreased but levels of MDA were elevated in patients with a chronic form of schizophrenia as compared with normal controls. SOD and GSH-Px activities were found to be significantly lower in paranoid and residual subtypes compared to both disorganized subtype and the control group. MDA levels were significantly higher in all subtypes compared to the control group. There were no significant differences in any parameters measured among all three subgroups treated with clozapine (n=44), risperidone (n=20) and typical antipsychotics (n=28). Additionally, a significantly higher MDA levels, but a significantly lower CAT activity was noted in female than male patients. These results suggest that oxidative stress may be implicated in the pathophysiology of all subtypes of schizophrenia, which may contribute to the increased membrane lipid peroxidation. Long-term treatments with typical and atypical antipsychotics may produce the similar effects on the antioxidant enzymes and lipid peroxidation. (c) 2005 Elsevier B.V All rights reserved.

语种英语
WOS记录号WOS:000235231300020
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被引频次:171[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56871
专题北京大学精神卫生研究所
作者单位1.Yale Univ, Sch Med, Dept Psychiat, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100037, Peoples R China
5.PUMC, Beijing, Peoples R China
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GB/T 7714
Zhang, XY,Tan, YL,Cao, LY,et al. Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics[J]. SCHIZOPHRENIA RESEARCH,2006,81(2-3):291-300.
APA Zhang, XY.,Tan, YL.,Cao, LY.,Wu, GY.,Xu, Q.,...&Zhou, DF.(2006).Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics.SCHIZOPHRENIA RESEARCH,81(2-3),291-300.
MLA Zhang, XY,et al."Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics".SCHIZOPHRENIA RESEARCH 81.2-3(2006):291-300.
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