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学科主题: 精神卫生
题名:
Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics
作者: Zhang, XY; Tan, YL; Cao, LY; Wu, GY; Xu, Q; Shen, Y; Zhou, DF
关键词: schizophrenia ; oxidative stress ; antioxidant enzymes ; lipid peroxidation ; antipsychotics ; psychopathology ; free radicals
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2006-01-31
DOI: 10.1016/j.schres.2005.10.011
卷: 81, 期:2-3, 页:291-300
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: BLOOD SUPEROXIDE-DISMUTASE ; FREE-RADICAL PATHOLOGY ; ESSENTIAL FATTY-ACIDS ; TARDIVE-DYSKINESIA ; GLUTATHIONE-PEROXIDASE ; THERAPEUTIC IMPLICATIONS ; DEFENSE SYSTEM ; GINKGO-BILOBA ; PLASMA ; HALOPERIDOL
英文摘要:

There is accumulating evidence of altered antioxidant enzyme activities and increased levels of lipid peroxidation in schizophrenia. Free radical-mediated abnormalities may contribute to specific aspects of schizophrenic symptomatology and complications of its treatment. However, few studies have evaluated both antioxidant enzymes and lipid peroxidation in the same schizophrenic patient groups treated with typical or atypical antipsychotics. Plasma malondialdehyde (NIDA) levels and superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) and catalase (CAT) activities were analyzed using established procedures in 92 medicated schizophrenia including paranoid (n=34), disorganized (n=18) and residual subtypes (n=40), as well as in control subjects (n=50). The results showed that activities of SOD and GSH-Px were decreased but levels of MDA were elevated in patients with a chronic form of schizophrenia as compared with normal controls. SOD and GSH-Px activities were found to be significantly lower in paranoid and residual subtypes compared to both disorganized subtype and the control group. MDA levels were significantly higher in all subtypes compared to the control group. There were no significant differences in any parameters measured among all three subgroups treated with clozapine (n=44), risperidone (n=20) and typical antipsychotics (n=28). Additionally, a significantly higher MDA levels, but a significantly lower CAT activity was noted in female than male patients. These results suggest that oxidative stress may be implicated in the pathophysiology of all subtypes of schizophrenia, which may contribute to the increased membrane lipid peroxidation. Long-term treatments with typical and atypical antipsychotics may produce the similar effects on the antioxidant enzymes and lipid peroxidation. (c) 2005 Elsevier B.V All rights reserved.

语种: 英语
WOS记录号: WOS:000235231300020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56871
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Yale Univ, Sch Med, Dept Psychiat, VA Connecticut Healthcare Syst, West Haven, CT 06516 USA
2.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
3.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
4.Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100037, Peoples R China
5.PUMC, Beijing, Peoples R China

Recommended Citation:
Zhang, XY,Tan, YL,Cao, LY,et al. Antioxidant enzymes and lipid peroxidation in different forms of schizophrenia treated with typical and atypical antipsychotics[J]. SCHIZOPHRENIA RESEARCH,2006,81(2-3):291-300.
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