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学科主题: 药学
题名:
Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
作者: Zhuang, Jie1; Ping, Qineng1; Song, Yunmei2; Qi, Jianping1; Cui, Zheng3
关键词: liposomes ; chitosan coating ; stability ; in vitro release ; prolonged retention time
刊名: INTERNATIONAL JOURNAL OF NANOMEDICINE
发表日期: 2010
卷: 5, 页:407-416
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]: Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]: MODIFIED POLYVINYL-ALCOHOL ; COATED LIPOSOMES ; STABILITY ; NANOPARTICLES ; CIRCULATION ; DELIVERY ; POLYMERS ; CARRIERS ; CHARGE ; SIZE
英文摘要:

The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction between CH and liposomes. The physical stability of the CH-coated liposomes was evaluated by measuring the change in particle size before and after freeze-drying and rehydration. The smallest change was observed when saturated adsorption of CH occurred (0.3%). The sustained release in vitro of MTO from CH-coated liposomes confirmed the increased stability of liposomes. Systemic circulation of CH-coated MTO liposomes was examined. The 0.3% CH-coated liposomes showed the longest circulation time. It could be concluded that the prolonged retention time of the liposomes was closely related with CH coating and its stability effect.

语种: 英语
所属项目编号: 30873183
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000283715300041
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56874
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharm, Beijing 100871, Peoples R China
2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China
3.Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia

Recommended Citation:
Zhuang, Jie,Ping, Qineng,Song, Yunmei,et al. Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2010,5:407-416.
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