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Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes
Zhuang, Jie1; Ping, Qineng1; Song, Yunmei2; Qi, Jianping1; Cui, Zheng3
关键词Liposomes Chitosan Coating Stability In Vitro Release Prolonged Retention Time
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
2010
5页:407-416
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]MODIFIED POLYVINYL-ALCOHOL ; COATED LIPOSOMES ; STABILITY ; NANOPARTICLES ; CIRCULATION ; DELIVERY ; POLYMERS ; CARRIERS ; CHARGE ; SIZE
英文摘要

The objective of this work was to evaluate the physical properties and in vivo circulation of chitosan (CH)-coated liposomes of mitoxantrone (MTO). Changes in particle size and zeta potential confirmed the existence of a coating layer on the surface of liposomes. The in vitro release of adsorbed CH from the liposomes was significantly slower than CH solution, indicating the stable interaction between CH and liposomes. The physical stability of the CH-coated liposomes was evaluated by measuring the change in particle size before and after freeze-drying and rehydration. The smallest change was observed when saturated adsorption of CH occurred (0.3%). The sustained release in vitro of MTO from CH-coated liposomes confirmed the increased stability of liposomes. Systemic circulation of CH-coated MTO liposomes was examined. The 0.3% CH-coated liposomes showed the longest circulation time. It could be concluded that the prolonged retention time of the liposomes was closely related with CH coating and its stability effect.

语种英语
WOS记录号WOS:000283715300041
引用统计
被引频次:26[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56874
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharm, Beijing 100871, Peoples R China
2.China Pharmaceut Univ, Sch Pharm, Nanjing 210009, Peoples R China
3.Univ S Australia, Sch Pharm & Med Sci, Adelaide, SA 5001, Australia
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GB/T 7714
Zhuang, Jie,Ping, Qineng,Song, Yunmei,et al. Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2010,5:407-416.
APA Zhuang, Jie,Ping, Qineng,Song, Yunmei,Qi, Jianping,&Cui, Zheng.(2010).Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes.INTERNATIONAL JOURNAL OF NANOMEDICINE,5,407-416.
MLA Zhuang, Jie,et al."Effects of chitosan coating on physical properties and pharmacokinetic behavior of mitoxantrone liposomes".INTERNATIONAL JOURNAL OF NANOMEDICINE 5(2010):407-416.
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