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学科主题: 口腔医学
题名:
A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment
作者: Li, Bin-Bin1; Xie, Xiao-Yan2; Jia, Sheng-Nan1
关键词: Adenoid cystic carcinoma ; Recurrence ; Salivary glands ; I-125 brachytherapy ; Pathology
刊名: ANNALS OF DIAGNOSTIC PATHOLOGY
发表日期: 2015-02-01
DOI: 10.1016/j.anndiagpath.2014.11.001
卷: 19, 期:1, 页:1-5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: RADIATION-THERAPY ; PROGNOSTIC-FACTORS ; SURGERY ; SARCOMA ; HEAD ; GLANDS ; CANCER ; TUMORS
英文摘要:

Recurrent adenoid cystic carcinoma (rAdCC) can be challenging to be treated with brachytherapy, although brachytherapy is safe and effective in treating head and neck cancers. Patients of adenoid cystic carcinoma (AdCC), who underwent resection and iodine 125 (I-125) radioactive seed implantation, were recruited for this study. Clinical data, surgical details of resection and seed implantation, histologic characteristics, and prognosis were studied. There were 16 rAdCC cases among 140 cases of AdCC treated with brachytherapy and resection. The mean follow-up duration for the recurrent cases was 61 months. The 3-year local control rate of rAdCC was 51.6%, and the overall disease-specific survival rate was 49.4%. Eight patients showed distant metastasis (50%, 8/16). The histologic grades of 10 rAdCCs were upgraded (62.5%, 10/16).Two cases displayed sarcomatous transformation after brachytherapy (1.4%, 2/140). Although the overall local control rate and survival rate were relatively favorable, some rAdCCs with an aggressive phenotype appeared to respond poorly to 1251 seed implantation. Preventive adjuvant chemotherapy should be prescribed for these rAdCCs. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000349506100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56888
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China

Recommended Citation:
Li, Bin-Bin,Xie, Xiao-Yan,Jia, Sheng-Nan. A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment[J]. ANNALS OF DIAGNOSTIC PATHOLOGY,2015,19(1):1-5.
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