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A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment
Li, Bin-Bin1; Xie, Xiao-Yan2; Jia, Sheng-Nan1
关键词Adenoid Cystic Carcinoma Recurrence Salivary Glands I-125 Brachytherapy Pathology
刊名ANNALS OF DIAGNOSTIC PATHOLOGY
2015-02-01
DOI10.1016/j.anndiagpath.2014.11.001
19期:1页:1-5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]RADIATION-THERAPY ; PROGNOSTIC-FACTORS ; SURGERY ; SARCOMA ; HEAD ; GLANDS ; CANCER ; TUMORS
英文摘要

Recurrent adenoid cystic carcinoma (rAdCC) can be challenging to be treated with brachytherapy, although brachytherapy is safe and effective in treating head and neck cancers. Patients of adenoid cystic carcinoma (AdCC), who underwent resection and iodine 125 (I-125) radioactive seed implantation, were recruited for this study. Clinical data, surgical details of resection and seed implantation, histologic characteristics, and prognosis were studied. There were 16 rAdCC cases among 140 cases of AdCC treated with brachytherapy and resection. The mean follow-up duration for the recurrent cases was 61 months. The 3-year local control rate of rAdCC was 51.6%, and the overall disease-specific survival rate was 49.4%. Eight patients showed distant metastasis (50%, 8/16). The histologic grades of 10 rAdCCs were upgraded (62.5%, 10/16).Two cases displayed sarcomatous transformation after brachytherapy (1.4%, 2/140). Although the overall local control rate and survival rate were relatively favorable, some rAdCCs with an aggressive phenotype appeared to respond poorly to 1251 seed implantation. Preventive adjuvant chemotherapy should be prescribed for these rAdCCs. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000349506100001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56888
Collection北京大学口腔医学院_口腔病理科
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Oral Pathol, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Oral Radiol, Beijing 100081, Peoples R China
Recommended Citation
GB/T 7714
Li, Bin-Bin,Xie, Xiao-Yan,Jia, Sheng-Nan. A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment[J]. ANNALS OF DIAGNOSTIC PATHOLOGY,2015,19(1):1-5.
APA Li, Bin-Bin,Xie, Xiao-Yan,&Jia, Sheng-Nan.(2015).A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment.ANNALS OF DIAGNOSTIC PATHOLOGY,19(1),1-5.
MLA Li, Bin-Bin,et al."A case-cohort study of recurrent salivary adenoid cystic carcinoma after iodine 125 brachytherapy and resection treatment".ANNALS OF DIAGNOSTIC PATHOLOGY 19.1(2015):1-5.
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