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学科主题口腔医学
Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft
Meng, Song1,2; Zhang, Xuehui3; Xu, Mingming1; Heng, Boon Chin4; Dai, Xiaohan5; Mo, Xiaoju1; Wei, Jinqi1; Wei, Yan1; Deng, Xuliang1,6,7
关键词Inorganic Xenograft Bone Deer Age Antler Physicochemical Properties Osteogenic Capability
刊名BIOMEDICAL MATERIALS
2015-06-01
DOI10.1088/1748-6041/10/3/035006
10期:3
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]X-RAY-DIFFRACTION ; BOVINE BONE ; OSTEOGENIC DIFFERENTIATION ; CARBONATED HYDROXYAPATITE ; NATURAL HYDROXYAPATITE ; IN-VITRO ; TRICALCIUM PHOSPHATE ; CHEMICAL-COMPOSITION ; MINERAL-CONTENT ; HEAT-TREATMENT
英文摘要

Inorganic bone xenograft materials have recently found extensive surgical application in the clinic. Previously we have demonstrated that calcinated antler cancellous bone (CACB) has great potential for bone defect repair, due to the similar structure and composition compared with human bone. However, the effect of intrinsic material characteristics, particularly deer age, on the physicochemical and biological properties of CACB scaffolds has not been clarified. The aim of this study is to investigate the structure, composition and in vitro solubility of CACB scaffolds derived from deer of varying ages, including young (CACB-Y), middle-aged (CACB-M), and old (CACB-O) deer, and to determine subsequent biological performance. Microstructural analyses showed looser crystal arrangement and lower porosity in CACB-M compared to CACB-Y and CACB-O. Phase-structure analysis showed that CACB-M had the largest crystal size. Component characterization results showed that CACB-M had the most carbonated substitute and the highest content of trace elements (Na, Fe). The in vitro solubility test showed that CACB-M had the fastest dissolution and apatite deposition rates with new crystalline phases. In addition, CACB-M could be conducive for attachment, proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro, as well as conducive for bone regeneration in vivo. These findings indicate that animal age should be seriously considered as a key parameter in optimizing the physicochemical and biological properties of deproteinized antler cancellous bone substitutes for bone regeneration applications.

语种英语
WOS记录号WOS:000357093000020
项目编号2012CB933900 ; 2011DFA32190 ; 81171000 ; 81425007 ; 20130001120112 ; 2012AA022501 ; 2015AA032004
资助机构National Basic Research Program of China ; Key International S&amp ; T Cooperation Project ; National Natural Science Foundation of China ; Doctoral Scientific Fund Project of the Ministry of Education of China ; National High Technology Research and Development Program of China ; Peking University-Tsinghua University Joint Center for Life Sciences
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56889
专题北京大学口腔医学院
北京大学第一临床医学院_超声诊断中心
北京大学口腔医学院_特诊科
北京大学临床肿瘤学院_乳腺癌预防治疗中心
作者单位1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China
4.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn D BSSE, CH-4058 Basel, Switzerland
5.Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130062, Peoples R China
6.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
7.Peking Univ, Sch & Hosp Stomatol, Beijing Lab Biomed Mat, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Meng, Song,Zhang, Xuehui,Xu, Mingming,et al. Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft[J]. BIOMEDICAL MATERIALS,2015,10(3).
APA Meng, Song.,Zhang, Xuehui.,Xu, Mingming.,Heng, Boon Chin.,Dai, Xiaohan.,...&Deng, Xuliang.(2015).Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft.BIOMEDICAL MATERIALS,10(3).
MLA Meng, Song,et al."Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft".BIOMEDICAL MATERIALS 10.3(2015).
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