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学科主题: 口腔医学
题名:
Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft
作者: Meng, Song1,2; Zhang, Xuehui3; Xu, Mingming1; Heng, Boon Chin4; Dai, Xiaohan5; Mo, Xiaoju1; Wei, Jinqi1; Wei, Yan1; Deng, Xuliang1,6,7
关键词: inorganic xenograft bone ; deer age ; antler ; physicochemical properties ; osteogenic capability
刊名: BIOMEDICAL MATERIALS
发表日期: 2015-06-01
DOI: 10.1088/1748-6041/10/3/035006
卷: 10, 期:3
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: X-RAY-DIFFRACTION ; BOVINE BONE ; OSTEOGENIC DIFFERENTIATION ; CARBONATED HYDROXYAPATITE ; NATURAL HYDROXYAPATITE ; IN-VITRO ; TRICALCIUM PHOSPHATE ; CHEMICAL-COMPOSITION ; MINERAL-CONTENT ; HEAT-TREATMENT
英文摘要:

Inorganic bone xenograft materials have recently found extensive surgical application in the clinic. Previously we have demonstrated that calcinated antler cancellous bone (CACB) has great potential for bone defect repair, due to the similar structure and composition compared with human bone. However, the effect of intrinsic material characteristics, particularly deer age, on the physicochemical and biological properties of CACB scaffolds has not been clarified. The aim of this study is to investigate the structure, composition and in vitro solubility of CACB scaffolds derived from deer of varying ages, including young (CACB-Y), middle-aged (CACB-M), and old (CACB-O) deer, and to determine subsequent biological performance. Microstructural analyses showed looser crystal arrangement and lower porosity in CACB-M compared to CACB-Y and CACB-O. Phase-structure analysis showed that CACB-M had the largest crystal size. Component characterization results showed that CACB-M had the most carbonated substitute and the highest content of trace elements (Na, Fe). The in vitro solubility test showed that CACB-M had the fastest dissolution and apatite deposition rates with new crystalline phases. In addition, CACB-M could be conducive for attachment, proliferation and osteogenic differentiation of rat bone marrow mesenchymal stem cells in vitro, as well as conducive for bone regeneration in vivo. These findings indicate that animal age should be seriously considered as a key parameter in optimizing the physicochemical and biological properties of deproteinized antler cancellous bone substitutes for bone regeneration applications.

语种: 英语
所属项目编号: 2012CB933900 ; 2011DFA32190 ; 81171000 ; 81425007 ; 20130001120112 ; 2012AA022501 ; 2015AA032004
项目资助者: National Basic Research Program of China ; Key International S&amp ; T Cooperation Project ; National Natural Science Foundation of China ; Doctoral Scientific Fund Project of the Ministry of Education of China ; National High Technology Research and Development Program of China ; Peking University-Tsinghua University Joint Center for Life Sciences
WOS记录号: WOS:000357093000020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56889
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Peking Univ, Sch & Hosp Stomatol, Dept Geriatr Dent, Beijing 100081, Peoples R China
2.Peking Univ, Sch & Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
3.Peking Univ, Sch & Hosp Stomatol, Dept Dent Mat, Beijing 100081, Peoples R China
4.Swiss Fed Inst Technol, Dept Biosyst Sci & Engn D BSSE, CH-4058 Basel, Switzerland
5.Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis,Minist Educ, Changchun 130062, Peoples R China
6.Natl Engn Lab Digital & Mat Technol Stomatol, Beijing 100081, Peoples R China
7.Peking Univ, Sch & Hosp Stomatol, Beijing Lab Biomed Mat, Beijing 100081, Peoples R China

Recommended Citation:
Meng, Song,Zhang, Xuehui,Xu, Mingming,et al. Effects of deer age on the physicochemical properties of deproteinized antler cancellous bone: an approach to optimize osteoconductivity of bone graft[J]. BIOMEDICAL MATERIALS,2015,10(3).
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