IR@PKUHSC  > 北京大学药学院
学科主题药学
Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors
Xiao, Su-long1,2; Wang, Qi2; Yu, Fei2; Peng, Yi-yun2; Yang, Ming2; Sollogoub, Matthieu1; Sinay, Pierre1; Zhang, Yong-min1,3; Zhang, Li-he2; Zhou, De-min2
关键词Alpha-cyclodextrin Fullerene Conjugate Hcv Entry
刊名BIOORGANIC & MEDICINAL CHEMISTRY
2012-09-15
DOI10.1016/j.bmc.2012.07.029
20期:18页:5616-5622
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Chemistry, Medicinal ; Chemistry, Organic
资助者China Scholarship Council ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Centre National de la Recherche Scientifique (CNRS) ; University Pierre &amp ; Marie Curie (UPMC) ; China Scholarship Council ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Centre National de la Recherche Scientifique (CNRS) ; University Pierre &amp ; Marie Curie (UPMC)
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy ; Chemistry
关键词[WOS]COMPLEXATION ; DERIVATIVES ; C-60
英文摘要

An alpha-cyclodextrin-[60] fullerene conjugate with a flexible linker at the secondary face of alpha-cyclodextrin has been prepared, which displays significant water solubility and, more importantly, acts as a new class of HCV entry inhibitor with IC50 at 0.17 mu M level. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
所属项目编号2010CB12300 ; 20932001 ; 20852001
资助者China Scholarship Council ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Centre National de la Recherche Scientifique (CNRS) ; University Pierre &amp ; Marie Curie (UPMC) ; China Scholarship Council ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Centre National de la Recherche Scientifique (CNRS) ; University Pierre &amp ; Marie Curie (UPMC)
WOS记录号WOS:000308808700032
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56893
Collection北京大学药学院
作者单位1.Univ Paris 06, Inst Parisien Chim Mol, UMR 7201, F-75005 Paris, France
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Jianghan Univ, Inst Interdisciplinary Res, Wuhan Econ & Technol Dev Zone, Wuhan 430056, Peoples R China
Recommended Citation
GB/T 7714
Xiao, Su-long,Wang, Qi,Yu, Fei,et al. Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors[J]. BIOORGANIC & MEDICINAL CHEMISTRY,2012,20(18):5616-5622.
APA Xiao, Su-long.,Wang, Qi.,Yu, Fei.,Peng, Yi-yun.,Yang, Ming.,...&Zhou, De-min.(2012).Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors.BIOORGANIC & MEDICINAL CHEMISTRY,20(18),5616-5622.
MLA Xiao, Su-long,et al."Conjugation of cyclodextrin with fullerene as a new class of HCV entry inhibitors".BIOORGANIC & MEDICINAL CHEMISTRY 20.18(2012):5616-5622.
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