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学科主题: 药学
题名:
Terpecurcumins A-I from the Rhizomes of Curcuma longa: Absolute Configuration and Cytotoxic Activity
作者: Lin, Xionghao1; Ji, Shuai1; Li, Rui1; Dong, Yinhui2; Qiao, Xue1; Hu, Hongbo2; Yang, Wenzhi1; Guo, Dean1; Tu, Pengfei1; Ye, Min1
刊名: JOURNAL OF NATURAL PRODUCTS
发表日期: 2012-12-01
DOI: 10.1021/np300551g
卷: 75, 期:12, 页:2121-2131
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: CANCER CELL-LINE ; BISABOLANE SESQUITERPENOIDS ; XANTHORRHIZA ZINGIBERACEAE ; CURCUMINOIDS ; DERIVATIVES ; TURMERONE ; APOPTOSIS ; TRIAL ; NMR ; L.
英文摘要:

Terpecurcumins A-I (1-9), together with three known analogues (10-12), were isolated from the rhizomes of Curcuma longa (turmeric). They were derived from the hybridization of curcuminoids and bisabolanes. The structures and absolute configurations of 1-9 were elucidated on the basis of extensive spectroscopic data analysis, including NMR and electronic circular dichroism spectra. The configuration of 10 was further confirmed by X-ray crystallography. A plausible biogenetic relationship for 1-12 is proposed. Compounds 4, 6, 7, 10, and 11 showed higher cytotoxic activities (IC50, 10.3-19.4 mu M) than curcumin (IC50, 31.3-49.2 mu M) against human cancer cell lines (A549, HepG2, and MDA-MB-231).

语种: 英语
所属项目编号: BMU20110269
项目资助者: Program for New Century Excellent Talents in University from Chinese Ministry of Education
WOS记录号: WOS:000312823300012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56895
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China

Recommended Citation:
Lin, Xionghao,Ji, Shuai,Li, Rui,et al. Terpecurcumins A-I from the Rhizomes of Curcuma longa: Absolute Configuration and Cytotoxic Activity[J]. JOURNAL OF NATURAL PRODUCTS,2012,75(12):2121-2131.
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