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Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery
Guo, Yangming1; Liu, Xing1; Sun, Xun1; Zhang, Qiang2; Gong, Tao1,3; Zhang, Zhirong1
关键词Lycorine Lipid Nano-emulsion Mannosylation Tumor Targeted Delivery
刊名THERANOSTICS
2012
DOI10.7150/thno.4525
2期:11页:1104-1114
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]IN-VITRO ; OCULAR BIOAVAILABILITY ; SUBMICRON EMULSIONS ; SORBIC ACID ; DRUG ; AMARYLLIDACEAE ; NANOPARTICLES ; NANOEMULSIONS ; TEMPERATURE ; DERIVATIVES
英文摘要

This study was to prepare a mannosylated lycorine lipid nano-emulsion formulation (M-LYC-OA-LNEs) for the aim of achieving tumor targeting delivery of lycorine (LYC). The low lipophilicity of LYC made it hard to be dispersed into lipid nano-emulsions (LNEs). In order to increase its lipophilicity, lycorine-oleic acid ionic complex (LYC-OA) was made. M-LYC-OA-LNEs and uncoated lycorine-oleic acid loaded lipid nano-emulsions (LYC-OA-LNEs) were prepared by solvent injection method and characterized by transmission electron microscopy (TEM), particle size, polydispersity index, zeta-potential and entrapment efficiency analysis. The in vitro cellular uptake and growth inhibition activity studies were performed on A549 cell lines. The entrapment efficiency of M-LYC-OA-LNEs was 82.7 +/- 1.6 %. The cellular uptake study showed that coated LNEs were preferably taken up by A549 cells than uncoated LNEs. The effective test by MTT assay showed better growth inhibition activity of M-LYC-OA-LNEs on A549 cell lines when compared with LYC-OA-LNEs and blank LNEs. These results demonstrated that M-LYC-OA-LNEs could be a promising formulation for tumor targeting delivery of LYC with the potential of being applied in the diagnosis and treatment of cancer.

语种英语
WOS记录号WOS:000312955800007
项目编号2009CB930300 ; 2012CB724002 ; 81130060
资助机构National Basic Research Programs of China (973 program) ; State Key Program of National Natural Science of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56896
专题北京大学药学院
作者单位1.Sichuan Univ, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, W China Sch Pharm, Chengdu 610041, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin, Peoples R China
推荐引用方式
GB/T 7714
Guo, Yangming,Liu, Xing,Sun, Xun,et al. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery[J]. THERANOSTICS,2012,2(11):1104-1114.
APA Guo, Yangming,Liu, Xing,Sun, Xun,Zhang, Qiang,Gong, Tao,&Zhang, Zhirong.(2012).Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery.THERANOSTICS,2(11),1104-1114.
MLA Guo, Yangming,et al."Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery".THERANOSTICS 2.11(2012):1104-1114.
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