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学科主题: 药学
题名:
Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery
作者: Guo, Yangming1; Liu, Xing1; Sun, Xun1; Zhang, Qiang2; Gong, Tao1,3; Zhang, Zhirong1
关键词: lycorine ; lipid nano-emulsion ; mannosylation ; tumor targeted delivery
刊名: THERANOSTICS
发表日期: 2012
DOI: 10.7150/thno.4525
卷: 2, 期:11, 页:1104-1114
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: IN-VITRO ; OCULAR BIOAVAILABILITY ; SUBMICRON EMULSIONS ; SORBIC ACID ; DRUG ; AMARYLLIDACEAE ; NANOPARTICLES ; NANOEMULSIONS ; TEMPERATURE ; DERIVATIVES
英文摘要:

This study was to prepare a mannosylated lycorine lipid nano-emulsion formulation (M-LYC-OA-LNEs) for the aim of achieving tumor targeting delivery of lycorine (LYC). The low lipophilicity of LYC made it hard to be dispersed into lipid nano-emulsions (LNEs). In order to increase its lipophilicity, lycorine-oleic acid ionic complex (LYC-OA) was made. M-LYC-OA-LNEs and uncoated lycorine-oleic acid loaded lipid nano-emulsions (LYC-OA-LNEs) were prepared by solvent injection method and characterized by transmission electron microscopy (TEM), particle size, polydispersity index, zeta-potential and entrapment efficiency analysis. The in vitro cellular uptake and growth inhibition activity studies were performed on A549 cell lines. The entrapment efficiency of M-LYC-OA-LNEs was 82.7 +/- 1.6 %. The cellular uptake study showed that coated LNEs were preferably taken up by A549 cells than uncoated LNEs. The effective test by MTT assay showed better growth inhibition activity of M-LYC-OA-LNEs on A549 cell lines when compared with LYC-OA-LNEs and blank LNEs. These results demonstrated that M-LYC-OA-LNEs could be a promising formulation for tumor targeting delivery of LYC with the potential of being applied in the diagnosis and treatment of cancer.

语种: 英语
所属项目编号: 2009CB930300 ; 2012CB724002 ; 81130060
项目资助者: National Basic Research Programs of China (973 program) ; State Key Program of National Natural Science of China
WOS记录号: WOS:000312955800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56896
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Sichuan Univ, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, W China Sch Pharm, Chengdu 610041, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing, Peoples R China
3.Tianjin Inst Pharmaceut Res, State Key Lab Drug Delivery Technol & Pharmacokin, Tianjin, Peoples R China

Recommended Citation:
Guo, Yangming,Liu, Xing,Sun, Xun,et al. Mannosylated Lipid Nano-emulsions Loaded with Lycorine-oleic Acid Ionic Complex for Tumor Cell-specific Delivery[J]. THERANOSTICS,2012,2(11):1104-1114.
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