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Gallstone Disease and the Risk of Ischemic Heart Disease
Lv, Jun1; Qi, Lu2,3,4; Yu, Canqing1; Guo, Yu5; Bian, Zheng5; Chen, Yiping6,7; Yang, Ling6,7; Shen, Jie8; Wang, Shanqing9; Li, Mingqiang10; Liu, Yongmei11; Zhang, Libo12; Chen, Junshi13; Chen, Zhengming6,7; Li, Liming1,5; China Kadoorie Biobank
关键词Cardiovascular Disease Chinese Ischemic Heart Diseases Longitudinal Cohort Study Risk Factor
刊名ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
2015-10-01
DOI10.1161/ATVBAHA.115.306043
35期:10页:2232-2237
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]GALLBLADDER-DISEASE ; GUT MICROBIOTA ; INSULIN ; ASSOCIATION ; METABOLISM ; ATHEROSCLEROSIS ; CHOLELITHIASIS ; PREVALENCE ; MEN
英文摘要

Objective Gallstone disease (GSD) is related to multiple cardiovascular risk factors; the present study was to prospectively examine the association between GSD and ischemic heart disease (IHD).

Approach and Results We examined the association of GSD with IHD among 199 292 men and 288 081 women aged 30-79 years in the China Kadoorie Biobank study. Participants with cancer, heart disease, and stroke at baseline were excluded. Cox proportional hazards regression model was used to estimate the association of GSD with IHD. The prevalence of self-reported GSD was 3.7% in men and 7.3% in women at baseline. During 3 431 124 person-years of follow-up between 2004 and 2013 (median, 7.2 years), we documented 10 245 incident IHD cases in men and 14 714 in women. As compared with men without GSD at baseline, the multivariate-adjusted hazard ratio for IHD was 1.11 (95% confidence interval, 1.02-1.22) for men with GSD; the respective hazard ratio was 1.27 (95% confidence interval, 1.20-1.34) in women and 1.23 (95% confidence interval, 1.17-1.28) in the whole cohort. The sex difference in IHD risk associated with GSD was statistically significant (P=0.009 for interaction with sex). In addition, we found that the association between GSD and IHD was stronger in nonhypertensive than in hypertensive women (P<0.001 for interaction).

Conclusions In this large prospective study, the presence of GSD was associated with an increased risk of incident IHD, independent of other risk factors of cardiovascular disease. Our findings suggest novel prevention strategy to mitigate heart disease through improvement of gastrointestinal health.

语种英语
WOS记录号WOS:000361610700020
项目编号81390544 ; 81390541 ; 2011BAI09B01 ; 088158/Z/09/Z ; HL071981 ; HL034594 ; HL126024 ; DK091718 ; DK100383 ; DK078616 ; DK46200 ; 2011036 ; 0730094N
资助机构National Natural Science Foundation of China ; National Key Technologies Research and Development Program in the 12th Five-year Plan, Chinese Ministry of Science and Technology ; Wellcome Trust in the United Kingdom ; Kadoorie Charitable Foundation in Hong Kong ; National Institute of Health grants from the National Heart, Lung, and Blood Institute ; National Institute of Diabetes and Digestive and Kidney Diseases ; Boston Obesity Nutrition Research Center ; United States-Israel Binational Science Foundation ; American Heart Association Scientist Development Award
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56898
专题北京大学公共卫生学院
作者单位1.Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
2.Harvard Univ, Sch Med, Boston, MA USA
3.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China
4.Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
5.Chinese Acad Med Sci, Beijing 100730, Peoples R China
6.Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford OX1 2JD, England
7.Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit CTSU, Oxford OX1 2JD, England
8.Suzhou Sanit Bur, Suzhou, Jiangsu, Peoples R China
9.Hainan Ctr Dis Control & Prevent, Haikou, Hainan, Peoples R China
10.Liuzhou Ctr Dis Control & Prevent, Liuzhou, Guangxi, Peoples R China
11.Qingdao Ctr Dis Control & Prevent, Dept Noncommunicable Dis Prevent & Control, Qingdao, Shandong, Peoples R China
12.Liuyang Ctr Dis Control & Prevent, Dept Noncommunicable Dis Prevent & Control, Changsha, Hunan, Peoples R China
13.China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Lv, Jun,Qi, Lu,Yu, Canqing,et al. Gallstone Disease and the Risk of Ischemic Heart Disease[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,2015,35(10):2232-2237.
APA Lv, Jun.,Qi, Lu.,Yu, Canqing.,Guo, Yu.,Bian, Zheng.,...&China Kadoorie Biobank.(2015).Gallstone Disease and the Risk of Ischemic Heart Disease.ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY,35(10),2232-2237.
MLA Lv, Jun,et al."Gallstone Disease and the Risk of Ischemic Heart Disease".ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 35.10(2015):2232-2237.
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