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TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy
Xi, Zhi-Qin; Wang, Lin-Yuan; Sun, Ji-Jun; Liu, Xian-Zeng; Zhu, Xi; Xiao, Fei; Guan, Li-Feng; Li, Jin-Mei; Wang, Liang; Wang, Xue-Feng
关键词t Cell Death-associated Gene 51 Epilepsy Apoptosis Patients
刊名NEUROSCIENCE LETTERS
2007-09-20
DOI10.1016/j.neulet.2007.08.016
425期:1页:53-58
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]KAINATE-INDUCED SEIZURES ; PROTEIN-KINASE-C ; TRAUMATIC BRAIN-INJURY ; ADULT-RAT BRAIN ; LOBE EPILEPSY ; STATUS EPILEPTICUS ; CELL-DEATH ; HIPPOCAMPAL SCLEROSIS ; INCREASED EXPRESSION ; ANTIEPILEPTIC DRUGS
英文摘要

TDAG51 (T cell death-associated gene 5 1) is an apoptosis-associated protein. Our aim was to investigate TDAG51 expression in the anterior temporal neocortex of patients with intractable epilepsy (IE), and then to discuss the possible role of TDAG51 in IE. Tissue samples from the anterior temporal neocortex of 33 patients who had surgery for IE were used to detect TDAG51 expression by immumohistochernistry, immunofluorescence, and Western blotting. We compared these tissues with nine histologically normal anterior temporal lobes from intracranial hypertension patients who had decompression procedures. TDAG51 was mainly expressed in the cytoplasm of neurons and glial cells. TDAG51 in IE was significantly higher than that in the controls. These findings were consistently observed using Western blotting, immunofluorescence, and inummohistochemistry techniques. TDAG51 in patients with IE was significantly higher when compared with levels in the controls. This finding suggests TDAG51 is consistent with a possible role of this gene in the evolution of the pathology in IE. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000250290100011
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56902
专题北京大学公共卫生学院
作者单位1.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China
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GB/T 7714
Xi, Zhi-Qin,Wang, Lin-Yuan,Sun, Ji-Jun,et al. TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy[J]. NEUROSCIENCE LETTERS,2007,425(1):53-58.
APA Xi, Zhi-Qin.,Wang, Lin-Yuan.,Sun, Ji-Jun.,Liu, Xian-Zeng.,Zhu, Xi.,...&Wang, Xue-Feng.(2007).TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy.NEUROSCIENCE LETTERS,425(1),53-58.
MLA Xi, Zhi-Qin,et al."TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy".NEUROSCIENCE LETTERS 425.1(2007):53-58.
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