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学科主题: 公共卫生
题名:
TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy
作者: Xi, Zhi-Qin; Wang, Lin-Yuan; Sun, Ji-Jun; Liu, Xian-Zeng; Zhu, Xi; Xiao, Fei; Guan, Li-Feng; Li, Jin-Mei; Wang, Liang; Wang, Xue-Feng
关键词: T cell death-associated gene 51 ; epilepsy ; apoptosis ; patients
刊名: NEUROSCIENCE LETTERS
发表日期: 2007-09-20
DOI: 10.1016/j.neulet.2007.08.016
卷: 425, 期:1, 页:53-58
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: KAINATE-INDUCED SEIZURES ; PROTEIN-KINASE-C ; TRAUMATIC BRAIN-INJURY ; ADULT-RAT BRAIN ; LOBE EPILEPSY ; STATUS EPILEPTICUS ; CELL-DEATH ; HIPPOCAMPAL SCLEROSIS ; INCREASED EXPRESSION ; ANTIEPILEPTIC DRUGS
英文摘要:

TDAG51 (T cell death-associated gene 5 1) is an apoptosis-associated protein. Our aim was to investigate TDAG51 expression in the anterior temporal neocortex of patients with intractable epilepsy (IE), and then to discuss the possible role of TDAG51 in IE. Tissue samples from the anterior temporal neocortex of 33 patients who had surgery for IE were used to detect TDAG51 expression by immumohistochernistry, immunofluorescence, and Western blotting. We compared these tissues with nine histologically normal anterior temporal lobes from intracranial hypertension patients who had decompression procedures. TDAG51 was mainly expressed in the cytoplasm of neurons and glial cells. TDAG51 in IE was significantly higher than that in the controls. These findings were consistently observed using Western blotting, immunofluorescence, and inummohistochemistry techniques. TDAG51 in patients with IE was significantly higher when compared with levels in the controls. This finding suggests TDAG51 is consistent with a possible role of this gene in the evolution of the pathology in IE. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000250290100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56902
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Neurol, Beijing 100044, Peoples R China

Recommended Citation:
Xi, Zhi-Qin,Wang, Lin-Yuan,Sun, Ji-Jun,et al. TDAG51 in the anterior temporal neocortex of patients with intractable epilepsy[J]. NEUROSCIENCE LETTERS,2007,425(1):53-58.
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