IR@PKUHSC  > 北京大学基础医学院  > 细胞生物学系
学科主题基础医学
ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA
Meng, Z.1,2; Li, M.1; He, Q.1; Jiang, S.1; Zhang, X.1; Xiao, J.1; Bai, Y.1
关键词Angiogenesis Angiopoietin-1 Cerebral Ischemia Neurogenesis Neuronal Differentiation Stroke
刊名NEUROSCIENCE
2014-05-16
DOI10.1016/j.neuroscience.2014.02.036
267页:135-146
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]NEURAL PROGENITOR CELLS ; OVEREXPRESSING ANGIOPOIETIN-1 ; ENHANCES ANGIOGENESIS ; ARTERY OCCLUSION ; TIE2 RECEPTOR ; STEM-CELLS ; RAT-BRAIN ; STROKE ; PATHWAY ; REPERFUSION
英文摘要

Neuropathologic processes such as cerebral ischemia can enhance neurogenesis. Angiopoietin-1 (Ang1) emerges as a critical regulator of physiological and pathological angiogenesis during embryonic and postnatal life. Although Ang1 could protect peripheral vasculature from vascular leakage following ischemic injury, the role of Ang1 in long-term neurological recovery after ischemic stroke remains elusive. This study aims to examine whether Ang1 overexpression via lentivirus-mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a rat model of focal cerebral ischemia. Our results demonstrated that lentivirus-mediated Ang1 gene transfer led to improved neurological behavior and reduced infarction volume, and protected against blood-brain barrier (BBB) leakage in the ischemic rats. In addition, we revealed that these effects of Ang1 are related to the ability of Ang1 to increase vascular density and accelerate endogenous neuronal differentiation. These findings suggest that Ang1 is a promising agent for the treatment of cerebral ischemia. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000334402700013
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56905
专题北京大学基础医学院_细胞生物学系
作者单位1.Shanxi Prov Peoples Hosp, Clin Lab, Taiyuan 030012, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
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GB/T 7714
Meng, Z.,Li, M.,He, Q.,et al. ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA[J]. NEUROSCIENCE,2014,267:135-146.
APA Meng, Z..,Li, M..,He, Q..,Jiang, S..,Zhang, X..,...&Bai, Y..(2014).ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA.NEUROSCIENCE,267,135-146.
MLA Meng, Z.,et al."ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA".NEUROSCIENCE 267(2014):135-146.
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