北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 细胞生物学系  > 期刊论文
学科主题: 基础医学
题名:
ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA
作者: Meng, Z.1,2; Li, M.1; He, Q.1; Jiang, S.1; Zhang, X.1; Xiao, J.1; Bai, Y.1
关键词: angiogenesis ; angiopoietin-1 ; cerebral ischemia ; neurogenesis ; neuronal differentiation ; stroke
刊名: NEUROSCIENCE
发表日期: 2014-05-16
DOI: 10.1016/j.neuroscience.2014.02.036
卷: 267, 页:135-146
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: NEURAL PROGENITOR CELLS ; OVEREXPRESSING ANGIOPOIETIN-1 ; ENHANCES ANGIOGENESIS ; ARTERY OCCLUSION ; TIE2 RECEPTOR ; STEM-CELLS ; RAT-BRAIN ; STROKE ; PATHWAY ; REPERFUSION
英文摘要:

Neuropathologic processes such as cerebral ischemia can enhance neurogenesis. Angiopoietin-1 (Ang1) emerges as a critical regulator of physiological and pathological angiogenesis during embryonic and postnatal life. Although Ang1 could protect peripheral vasculature from vascular leakage following ischemic injury, the role of Ang1 in long-term neurological recovery after ischemic stroke remains elusive. This study aims to examine whether Ang1 overexpression via lentivirus-mediated gene transfer enhances neurovascular remodeling and improves functional outcome in a rat model of focal cerebral ischemia. Our results demonstrated that lentivirus-mediated Ang1 gene transfer led to improved neurological behavior and reduced infarction volume, and protected against blood-brain barrier (BBB) leakage in the ischemic rats. In addition, we revealed that these effects of Ang1 are related to the ability of Ang1 to increase vascular density and accelerate endogenous neuronal differentiation. These findings suggest that Ang1 is a promising agent for the treatment of cerebral ischemia. (C) 2014 IBRO. Published by Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 31070948 ; 81272432
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000334402700013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56905
Appears in Collections:基础医学院_细胞生物学系_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Shanxi Prov Peoples Hosp, Clin Lab, Taiyuan 030012, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Meng, Z.,Li, M.,He, Q.,et al. ECTOPIC EXPRESSION OF HUMAN ANGIOPOIETIN-1 PROMOTES FUNCTIONAL RECOVERY AND NEUROGENESIS AFTER FOCAL CEREBRAL ISCHEMIA[J]. NEUROSCIENCE,2014,267:135-146.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Meng, Z.]'s Articles
[Li, M.]'s Articles
[He, Q.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Meng, Z.]‘s Articles
[Li, M.]‘s Articles
[He, Q.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace