IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice
Zhang, Jing1,2; Wu, Zhouqiao3; Zhou, Linglin4; Li, Huili5; Teng, Huajing1; Dai, Wei1; Wang, Yongqing1; Sun, Zhong Sheng1
刊名PLOS ONE
2011-01-14
DOI10.1371/journal.pone.0016212
6期:1
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MAMMALIAN CIRCADIAN CLOCK ; INDUCED ANALGESIA ; ANALYSIS ALGORITHM ; HPA AXIS ; BEHAVIOR ; MPER2 ; MOUSE ; VASOPRESSIN ; OXYTOCIN ; SYSTEM
英文摘要

Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are considered as molecular markers for stress-induced grooming behavior. Oxytocin in PVN is an essential modulator for stress-induced antinociception. The clock gene, Per1, has been identified as an effecter response to the acute stresses, but its function in neuroendocrine stress systems remains unclear. In the present study we observed the alterations in grooming and nociceptive behaviors induced by acute immobilization stress in Per1 mutant mice and other genotypes (wild types and Per2 mutant). The results displayed that stress elicited a more robust effect on grooming behavior in Per1 mutant mice than in other genotypes. Subsequently, the obvious stress-induced antinociception was observed in the wild-type and Per2 mutant mice, however, in Per1 mutant, this antinociceptive effects were partially-reversed (mechanical sensitivity), or over-reversed to hyperalgesia (thermal sensitivity). The real-time qPCR results showed that in PVN, there were stress-induced up-regulations of Crh, Avp and c-fos in all of genotypes; moreover, the expression change of Crh in Per1 mutant mice was much larger than in others. Another hormonal gene, Oxt, was up-regulated induced by stress in wild-type and Per2 mutant but not in Per1 mutant. In addition, the stress significantly elevated the serum corticosterone levels without genotype-dependent differences, and accordingly the glucocorticoid receptor gene, Nr3c1, expressed with a similar pattern in PVN of all strains. Taken together, the present study indicated that in acute stress treated Per1 mutant mice, there are abnormal hormonal responses in PVN, correlating with the aberrant performance of stress-induced behaviors. Therefore, our findings suggest a novel functional role of Per1 in neuroendocrine stress system, which further participates in analgesic regulation.

语种英语
所属项目编号31071133 ; 2007CB512302
资助者National Natural Science Foundation of China ; Major State Basic Research Development Program of China ; National Natural Science Foundation of China ; Major State Basic Research Development Program of China
WOS记录号WOS:000286516500040
Citation statistics
Cited Times:9[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56906
Collection北京大学第三临床医学院
作者单位1.Capital Inst Pediat, Beijing, Peoples R China
2.Chinese Acad Sci, Behav Genet Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Wenzhou Med Coll, Inst Genom Med, Wenzhou, Zhejiang, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jing,Wu, Zhouqiao,Zhou, Linglin,et al. Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice[J]. PLOS ONE,2011,6(1).
APA Zhang, Jing.,Wu, Zhouqiao.,Zhou, Linglin.,Li, Huili.,Teng, Huajing.,...&Sun, Zhong Sheng.(2011).Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice.PLOS ONE,6(1).
MLA Zhang, Jing,et al."Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice".PLOS ONE 6.1(2011).
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Zhang, Jing]'s Articles
[Wu, Zhouqiao]'s Articles
[Zhou, Linglin]'s Articles
百度学术
百度学术Similar articles in
[Zhang, Jing]'s Articles
[Wu, Zhouqiao]'s Articles
[Zhou, Linglin]'s Articles
必应学术
必应学术Similar articles in
[Zhang, Jing]'s Articles
[Wu, Zhouqiao]'s Articles
[Zhou, Linglin]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.