北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice
作者: Zhang, Jing1,2; Wu, Zhouqiao3; Zhou, Linglin4; Li, Huili5; Teng, Huajing1; Dai, Wei1; Wang, Yongqing1; Sun, Zhong Sheng1
刊名: PLOS ONE
发表日期: 2011-01-14
DOI: 10.1371/journal.pone.0016212
卷: 6, 期:1
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MAMMALIAN CIRCADIAN CLOCK ; INDUCED ANALGESIA ; ANALYSIS ALGORITHM ; HPA AXIS ; BEHAVIOR ; MPER2 ; MOUSE ; VASOPRESSIN ; OXYTOCIN ; SYSTEM
英文摘要:

Acute stressors induce changes in numerous behavioral parameters through activation of the hypothalamic-pituitary-adrenal (HPA) axis. Several important hormones in paraventricular nucleus of the hypothalamus (PVN) play the roles in these stress-induced reactions. Corticotropin-releasing hormone (CRH), arginine-vasopressin (AVP) and corticosterone are considered as molecular markers for stress-induced grooming behavior. Oxytocin in PVN is an essential modulator for stress-induced antinociception. The clock gene, Per1, has been identified as an effecter response to the acute stresses, but its function in neuroendocrine stress systems remains unclear. In the present study we observed the alterations in grooming and nociceptive behaviors induced by acute immobilization stress in Per1 mutant mice and other genotypes (wild types and Per2 mutant). The results displayed that stress elicited a more robust effect on grooming behavior in Per1 mutant mice than in other genotypes. Subsequently, the obvious stress-induced antinociception was observed in the wild-type and Per2 mutant mice, however, in Per1 mutant, this antinociceptive effects were partially-reversed (mechanical sensitivity), or over-reversed to hyperalgesia (thermal sensitivity). The real-time qPCR results showed that in PVN, there were stress-induced up-regulations of Crh, Avp and c-fos in all of genotypes; moreover, the expression change of Crh in Per1 mutant mice was much larger than in others. Another hormonal gene, Oxt, was up-regulated induced by stress in wild-type and Per2 mutant but not in Per1 mutant. In addition, the stress significantly elevated the serum corticosterone levels without genotype-dependent differences, and accordingly the glucocorticoid receptor gene, Nr3c1, expressed with a similar pattern in PVN of all strains. Taken together, the present study indicated that in acute stress treated Per1 mutant mice, there are abnormal hormonal responses in PVN, correlating with the aberrant performance of stress-induced behaviors. Therefore, our findings suggest a novel functional role of Per1 in neuroendocrine stress system, which further participates in analgesic regulation.

语种: 英语
所属项目编号: 31071133 ; 2007CB512302
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program of China
WOS记录号: WOS:000286516500040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56906
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Capital Inst Pediat, Beijing, Peoples R China
2.Chinese Acad Sci, Behav Genet Ctr, Beijing, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing, Peoples R China
4.Peking Univ, Hosp 3, Hlth Sci Ctr, Beijing 100871, Peoples R China
5.Wenzhou Med Coll, Inst Genom Med, Wenzhou, Zhejiang, Peoples R China

Recommended Citation:
Zhang, Jing,Wu, Zhouqiao,Zhou, Linglin,et al. Deficiency of Antinociception and Excessive Grooming Induced by Acute Immobilization Stress in Per1 Mutant Mice[J]. PLOS ONE,2011,6(1).
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Zhang, Jing]'s Articles
[Wu, Zhouqiao]'s Articles
[Zhou, Linglin]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Zhang, Jing]‘s Articles
[Wu, Zhouqiao]‘s Articles
[Zhou, Linglin]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新
 !E >

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace