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Synthetic iminosugar derivatives as new potential immunosuppressive agents
Ye, XS; Sun, F; Liu, M; Li, Q; Wang, YH; Zhang, GS; Zhang, LH; Zhang, XL
刊名JOURNAL OF MEDICINAL CHEMISTRY
2005-06-02
DOI10.1021/jm050169t
48期:11页:3688-3691
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]GLYCOSIDASE INHIBITORS ; CASTANOSPERMINE ; TRANSPLANTATION ; CYCLOSPORINE ; RESPONSES
英文摘要

Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-gamma from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated molecules (CD19) were also investigated. The experimental data demonstrated that synthetic iminosugars hold potential as immunosuppressive agents.

语种英语
WOS记录号WOS:000229443700004
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被引频次:58[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56908
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453002, Peoples R China
3.Wuhan Univ, Coll Med, Dept Immunol, Wuhan 430071, Peoples R China
推荐引用方式
GB/T 7714
Ye, XS,Sun, F,Liu, M,et al. Synthetic iminosugar derivatives as new potential immunosuppressive agents[J]. JOURNAL OF MEDICINAL CHEMISTRY,2005,48(11):3688-3691.
APA Ye, XS.,Sun, F.,Liu, M.,Li, Q.,Wang, YH.,...&Zhang, XL.(2005).Synthetic iminosugar derivatives as new potential immunosuppressive agents.JOURNAL OF MEDICINAL CHEMISTRY,48(11),3688-3691.
MLA Ye, XS,et al."Synthetic iminosugar derivatives as new potential immunosuppressive agents".JOURNAL OF MEDICINAL CHEMISTRY 48.11(2005):3688-3691.
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