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学科主题: 药学
题名:
Synthetic iminosugar derivatives as new potential immunosuppressive agents
作者: Ye, XS; Sun, F; Liu, M; Li, Q; Wang, YH; Zhang, GS; Zhang, LH; Zhang, XL
刊名: JOURNAL OF MEDICINAL CHEMISTRY
发表日期: 2005-06-02
DOI: 10.1021/jm050169t
卷: 48, 期:11, 页:3688-3691
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GLYCOSIDASE INHIBITORS ; CASTANOSPERMINE ; TRANSPLANTATION ; CYCLOSPORINE ; RESPONSES
英文摘要:

Several iminosugar derivatives were synthesized, and their effects on the secretion of IL-4 and IFN-gamma from the mouse splenocytes were examined. The effects on membrane expression of other T cell-associated molecules (CD3, CD4, CD8) and B cell-associated molecules (CD19) were also investigated. The experimental data demonstrated that synthetic iminosugars hold potential as immunosuppressive agents.

语种: 英语
WOS记录号: WOS:000229443700004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56908
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Henan Normal Univ, Coll Chem & Environm Sci, Xinxiang 453002, Peoples R China
3.Wuhan Univ, Coll Med, Dept Immunol, Wuhan 430071, Peoples R China

Recommended Citation:
Ye, XS,Sun, F,Liu, M,et al. Synthetic iminosugar derivatives as new potential immunosuppressive agents[J]. JOURNAL OF MEDICINAL CHEMISTRY,2005,48(11):3688-3691.
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