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学科主题: 公共卫生
题名:
Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration
作者: Huang, Yang-Mu1; Yan, Shao-Fang1; Ma, Le1; Zou, Zhi-Yong1; Xu, Xian-Rong1; Dou, Hong-Liang2; Lin, Xiao-Ming1
关键词: Lutein ; Zeaxanthin ; Early age-related macular degeneration ; Serum concentration ; Macular pigment optical density
刊名: NUTRITION
发表日期: 2013-02-01
DOI: 10.1016/j.nut.2012.06.009
卷: 29, 期:2, 页:387-392
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: PIGMENT OPTICAL-DENSITY ; FUNDUS AUTOFLUORESCENCE ; HUMAN RETINA ; EYE DISEASE ; LUTEIN ; ZEAXANTHIN ; AREDS ; CAROTENOIDS ; PLASMA
英文摘要:

Objective: This randomized controlled trial examined serum and macular (in vivo measured macular pigment optical density [MPOD]) responses to supplemental lutein and zeaxanthin in Chinese subjects with early age-related macular degeneration.

Methods: One hundred and eight patients with early age-related macular degeneration older than 50 y were randomized to low lutein (LL; 10 mg/d), high lutein (HL; 20 mg/d), lutein plus zeaxanthin (LZ; each 10 mg/d), or placebo during a 48-wk intervention. Serum concentrations were quantified by C-30 high-performance liquid chromatography (at baseline and 4, 12, 24, and 48 wk), and MPOD was measured by analysis of autofluorescence images (at baseline and 24 and 48 wk).

Results: Serum lutein levels in the LL, LZ, and HL groups increased significantly in the first 4 wk and then increased 4.24-, 4.66-, and 6.23-fold during the trial, respectively (all P < 0.001). The serum lutein level in the HL group was significantly higher than that in the LL or LZ group at 48 wk (P < 0.05). Similarly, the serum zeaxanthin concentration in the 12 group increased 3.11-fold at 48 wk. MPOD increased smoothly in all treated groups, and the increase from baseline was greatest in the HL group at 24 and 48 wk (both P < 0.05). MPOD and serum lutein levels increased linearly with the dosage and their increasing rates were statistically correlated (all P < 0.05). No notable changes were detected in the placebo group for MPOD and serum concentrations.

Conclusion: Xanthophyll supplementation significantly increased serum concentrations and MPOD in patients with early age-related macular degeneration, and a higher lutein supplementation (20 mg/d) might be more effective in increasing these two biochemical markers in Chinese patients without significant side effects. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: NSFC-30872113
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000314443600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56910
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Beijing Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
2.Beijing Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China

Recommended Citation:
Huang, Yang-Mu,Yan, Shao-Fang,Ma, Le,et al. Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration[J]. NUTRITION,2013,29(2):387-392.
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