|Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration|
|Huang, Yang-Mu1; Yan, Shao-Fang1; Ma, Le1; Zou, Zhi-Yong1; Xu, Xian-Rong1; Dou, Hong-Liang2; Lin, Xiao-Ming1|
|关键词||Lutein Zeaxanthin Early Age-related Macular Degeneration Serum Concentration Macular Pigment Optical Density|
|WOS标题词||Science & Technology|
|类目[WOS]||Nutrition & Dietetics|
|研究领域[WOS]||Nutrition & Dietetics|
|关键词[WOS]||PIGMENT OPTICAL-DENSITY ; FUNDUS AUTOFLUORESCENCE ; HUMAN RETINA ; EYE DISEASE ; LUTEIN ; ZEAXANTHIN ; AREDS ; CAROTENOIDS ; PLASMA|
Objective: This randomized controlled trial examined serum and macular (in vivo measured macular pigment optical density [MPOD]) responses to supplemental lutein and zeaxanthin in Chinese subjects with early age-related macular degeneration.
Methods: One hundred and eight patients with early age-related macular degeneration older than 50 y were randomized to low lutein (LL; 10 mg/d), high lutein (HL; 20 mg/d), lutein plus zeaxanthin (LZ; each 10 mg/d), or placebo during a 48-wk intervention. Serum concentrations were quantified by C-30 high-performance liquid chromatography (at baseline and 4, 12, 24, and 48 wk), and MPOD was measured by analysis of autofluorescence images (at baseline and 24 and 48 wk).
Results: Serum lutein levels in the LL, LZ, and HL groups increased significantly in the first 4 wk and then increased 4.24-, 4.66-, and 6.23-fold during the trial, respectively (all P < 0.001). The serum lutein level in the HL group was significantly higher than that in the LL or LZ group at 48 wk (P < 0.05). Similarly, the serum zeaxanthin concentration in the 12 group increased 3.11-fold at 48 wk. MPOD increased smoothly in all treated groups, and the increase from baseline was greatest in the HL group at 24 and 48 wk (both P < 0.05). MPOD and serum lutein levels increased linearly with the dosage and their increasing rates were statistically correlated (all P < 0.05). No notable changes were detected in the placebo group for MPOD and serum concentrations.
Conclusion: Xanthophyll supplementation significantly increased serum concentrations and MPOD in patients with early age-related macular degeneration, and a higher lutein supplementation (20 mg/d) might be more effective in increasing these two biochemical markers in Chinese patients without significant side effects. (C) 2013 Elsevier Inc. All rights reserved.
|作者单位||1.Beijing Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China|
2.Beijing Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China
|Huang, Yang-Mu,Yan, Shao-Fang,Ma, Le,et al. Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration[J]. NUTRITION,2013,29(2):387-392.|
|APA||Huang, Yang-Mu.,Yan, Shao-Fang.,Ma, Le.,Zou, Zhi-Yong.,Xu, Xian-Rong.,...&Lin, Xiao-Ming.(2013).Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration.NUTRITION,29(2),387-392.|
|MLA||Huang, Yang-Mu,et al."Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration".NUTRITION 29.2(2013):387-392.|