IR@PKUHSC  > 北京大学公共卫生学院
学科主题公共卫生
Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration
Huang, Yang-Mu1; Yan, Shao-Fang1; Ma, Le1; Zou, Zhi-Yong1; Xu, Xian-Rong1; Dou, Hong-Liang2; Lin, Xiao-Ming1
关键词Lutein Zeaxanthin Early Age-related Macular Degeneration Serum Concentration Macular Pigment Optical Density
刊名NUTRITION
2013-02-01
DOI10.1016/j.nut.2012.06.009
29期:2页:387-392
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nutrition & Dietetics
研究领域[WOS]Nutrition & Dietetics
关键词[WOS]PIGMENT OPTICAL-DENSITY ; FUNDUS AUTOFLUORESCENCE ; HUMAN RETINA ; EYE DISEASE ; LUTEIN ; ZEAXANTHIN ; AREDS ; CAROTENOIDS ; PLASMA
英文摘要

Objective: This randomized controlled trial examined serum and macular (in vivo measured macular pigment optical density [MPOD]) responses to supplemental lutein and zeaxanthin in Chinese subjects with early age-related macular degeneration.

Methods: One hundred and eight patients with early age-related macular degeneration older than 50 y were randomized to low lutein (LL; 10 mg/d), high lutein (HL; 20 mg/d), lutein plus zeaxanthin (LZ; each 10 mg/d), or placebo during a 48-wk intervention. Serum concentrations were quantified by C-30 high-performance liquid chromatography (at baseline and 4, 12, 24, and 48 wk), and MPOD was measured by analysis of autofluorescence images (at baseline and 24 and 48 wk).

Results: Serum lutein levels in the LL, LZ, and HL groups increased significantly in the first 4 wk and then increased 4.24-, 4.66-, and 6.23-fold during the trial, respectively (all P < 0.001). The serum lutein level in the HL group was significantly higher than that in the LL or LZ group at 48 wk (P < 0.05). Similarly, the serum zeaxanthin concentration in the 12 group increased 3.11-fold at 48 wk. MPOD increased smoothly in all treated groups, and the increase from baseline was greatest in the HL group at 24 and 48 wk (both P < 0.05). MPOD and serum lutein levels increased linearly with the dosage and their increasing rates were statistically correlated (all P < 0.05). No notable changes were detected in the placebo group for MPOD and serum concentrations.

Conclusion: Xanthophyll supplementation significantly increased serum concentrations and MPOD in patients with early age-related macular degeneration, and a higher lutein supplementation (20 mg/d) might be more effective in increasing these two biochemical markers in Chinese patients without significant side effects. (C) 2013 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000314443600004
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56910
专题北京大学公共卫生学院
北京大学公共卫生学院_全球卫生学系
北京大学公共卫生学院_公共卫生学院
北京大学第三临床医学院_眼科
作者单位1.Beijing Univ, Hosp 3, Ctr Eye, Beijing 100871, Peoples R China
2.Beijing Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Huang, Yang-Mu,Yan, Shao-Fang,Ma, Le,et al. Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration[J]. NUTRITION,2013,29(2):387-392.
APA Huang, Yang-Mu.,Yan, Shao-Fang.,Ma, Le.,Zou, Zhi-Yong.,Xu, Xian-Rong.,...&Lin, Xiao-Ming.(2013).Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration.NUTRITION,29(2),387-392.
MLA Huang, Yang-Mu,et al."Serum and macular responses to multiple xanthophyll supplements in patients with early age-related macular degeneration".NUTRITION 29.2(2013):387-392.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Huang, Yang-Mu]的文章
[Yan, Shao-Fang]的文章
[Ma, Le]的文章
百度学术
百度学术中相似的文章
[Huang, Yang-Mu]的文章
[Yan, Shao-Fang]的文章
[Ma, Le]的文章
必应学术
必应学术中相似的文章
[Huang, Yang-Mu]的文章
[Yan, Shao-Fang]的文章
[Ma, Le]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。