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Vaccination with immunoglobulin frame region-derived nonapeptide elicits cellular immune response against lymphoma in human leukocyte antigen-A2.1 transgenic mice
Liu, Hui1; Cai, Peng2; Liu, Hong-Xing2; Wang, Jian-Ling2; Liu, Qian1; Zhu, Ping1
关键词B-cell Lymphoma Immunoglobulin Ighv Framework Region Cytotoxic t Lymphocytes
刊名LEUKEMIA & LYMPHOMA
2011-09-01
DOI10.3109/10428194.2011.577257
52期:9页:1795-1802
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology
研究领域[WOS]Oncology ; Hematology
关键词[WOS]COLONY-STIMULATING FACTOR ; CYTOTOXIC T-LYMPHOCYTES ; IDIOTYPE VACCINES ; CLINICAL-TRIAL ; HEAVY-CHAIN ; PEPTIDES ; EPITOPES ; TUMOR ; PROTEINS ; CELLS
英文摘要

The epitope in the frame region (FR) of the immunoglobulin heavy chain variable region (IgHV) is a potential target for lymphoma immunotherapy. Our previous work identified a FR-derived nonapeptide (QLVQSGAEV) capable of in vitro eliciting anti-lymphoma specific cytotoxic T lymphocytes (CTLs) in lymphocytes from human leukocyte antigen (HLA)-A2.1 donors. Here we used HLA-A2.1 transgenic mice and SCID (severe combined immunodeficiency) mice to confirm the ability of these specific CTLs against lymphomas. We immunized transgenic mice with nonapeptide conjugated to the adjuvant of PADRE (pan HLA DR-binding epitope). The specificity of the elicited CTLs from the immunized transgenic mice was identified by enzyme-linked immunospot (ELISpot) assay and pentamer staining. The elicited CTLs specifically attacked lymphomas with surface IgHV1 in vitro. Adoptive transfer of the CTLs to SCID mice loaded with QLVQSGAEV(+)/HLA-A2.1(+) lymphoma cells effectively inhibited tumor growth. Our results indicate that the relatively constant epitope in the IgHV FR may be useful for immunotherapy of lymphomas with the same IgHV subfamily.

语种英语
WOS记录号WOS:000294228100026
项目编号2006DFB31430 ; 2008AA02503
资助机构Ministry of Science &amp ; Technology of China ; National 863 High-Tech Research and Development Program of China
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56915
专题北京大学第一临床医学院_血液内科
作者单位1.Dao Pei Hosp, Lab Hematol Res, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
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GB/T 7714
Liu, Hui,Cai, Peng,Liu, Hong-Xing,et al. Vaccination with immunoglobulin frame region-derived nonapeptide elicits cellular immune response against lymphoma in human leukocyte antigen-A2.1 transgenic mice[J]. LEUKEMIA & LYMPHOMA,2011,52(9):1795-1802.
APA Liu, Hui,Cai, Peng,Liu, Hong-Xing,Wang, Jian-Ling,Liu, Qian,&Zhu, Ping.(2011).Vaccination with immunoglobulin frame region-derived nonapeptide elicits cellular immune response against lymphoma in human leukocyte antigen-A2.1 transgenic mice.LEUKEMIA & LYMPHOMA,52(9),1795-1802.
MLA Liu, Hui,et al."Vaccination with immunoglobulin frame region-derived nonapeptide elicits cellular immune response against lymphoma in human leukocyte antigen-A2.1 transgenic mice".LEUKEMIA & LYMPHOMA 52.9(2011):1795-1802.
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