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IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan
作者: Ji, Yuelong1; Kong, Xiangyi2; Wang, Guoying1; Hong, Xiumei1; Xu, Xin3,4; Chen, Zhu1; Bartell, Tami5; Xu, Xiping3,4; Tang, Genfu6; Hou, Fanfan4; Huo, Yong7; Wang, Xiaobin1,8; Wang, Binyan4
关键词: homocysteine ; Chinese twins ; heritability ; gender difference ; smoking
刊名: NUTRIENTS
发表日期: 2014-12-01
DOI: 10.3390/nu6125900
卷: 6, 期:12, 页:5900-5914
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: POPULATION-BASED TWIN ; FOLIC-ACID ; CARDIOVASCULAR-DISEASE ; METABOLIC SYNDROME ; C677T POLYMORPHISM ; MTHFR C677T ; RISK-FACTOR ; METAANALYSIS ; ADULTS ; ASSOCIATION
英文摘要:

Plasma homocysteine (Hcy) is a modifiable, independent risk factor for cardiovascular disease (CVD) and is affected by both environmental and genetic factors. This study aimed to describe the gender- and age-specific distribution of Hcy concentration for 1117 subjects aged 10-66 years, a subset of a community-based rural Chinese twin cohort. In addition, we examined environmental and genetic contributions to variances in Hcy concentration by gender and age groups. We found that the distribution pattern for Hcy varied by both age and gender. Males had higher Hcy than females across all ages. Elevated Hcy was found in 43% of male adults and 13% of female adults. Moreover, nearly one fifth of children had elevated Hcy. Genetic factors could explain 52%, 36% and 69% of the variation in Hcy concentration among children, male adults and female adults, respectively. The MTHFR C677T variant was significantly associated with Hcy concentrations. Smokers with the TT genotype had the highest Hcy levels. Overall, our results indicate that elevated Hcy is prevalent in the children and adults in this rural Chinese population. The early identification of elevated Hcy will offer a window of opportunity for the primary prevention of CVD and metabolic syndrome.

语种: 英语
所属项目编号: R01 HD049059 ; R01 HL086461 ; R01 AG032227
项目资助者: National Institute of Child Health and Human Development ; National Heart, Lung and Blood Institute ; National Institute of Aging
WOS记录号: WOS:000346796100033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56919
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Ctr Early Life Origins Dis, Dept Populat Family & Reprod Hlth, Baltimore, MD 21205 USA
2.Beijing Capital Med Univ, Anzen Hosp, Beijing 100069, Peoples R China
3.Anhui Med Univ, Inst Biomed, Hefei 230032, Peoples R China
4.Southern Med Univ, Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, Guangzhou 510515, Guangdong, Peoples R China
5.Stanley Manne Childrens Res Inst, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
6.Anhui Med Univ, Sch Hlth Adm, Hefei 230032, Peoples R China
7.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China
8.Johns Hopkins Univ, Sch Med, Div Gen Pediat & Adolescent Med, Dept Pediat, Baltimore, MD 21205 USA

Recommended Citation:
Ji, Yuelong,Kong, Xiangyi,Wang, Guoying,et al. Distribution and Determinants of Plasma Homocysteine Levels in Rural Chinese Twins across the Lifespan[J]. NUTRIENTS,2014,6(12):5900-5914.
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