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学科主题: 基础医学
题名:
Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils
作者: Zhang, Zhang1,2; Huang, Tao1,2; Yu, Feiyuan1,2; Liu, Xingmu1,2; Zhao, Conghui3; Chen, Xueling1,2; Kelvin, David J.4,5,6,7,8; Gu, Jiang1,2,3,9
刊名: SCIENTIFIC REPORTS
发表日期: 2015-12-07
DOI: 10.1038/srep17809
期: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: RIBONUCLEIC ACID BIOSYNTHESIS ; A H5N1 VIRUS ; AVIAN INFLUENZA ; POLYMORPHONUCLEAR LEUKOCYTES ; RESPIRATORY-TRACT ; RECEPTOR-BINDING ; MESSENGER-RNA ; SIALIC-ACID ; HEMAGGLUTININ ; CELLS
英文摘要:

Various reports have indicated that a number of viruses could infect neutrophils, but the multiplication of viruses in neutrophils was abortive. Based on our previous finding that avian influenza viral RNA and proteins were present in the nucleus of infected human neutrophils in vivo, we investigated the possibility of 2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible release of infectious progeny from host cells. In this study we found that human neutrophils in vitro without detectable level of sialic acid expression could be infected by this virus strain. We also show that the infected neutrophils can not only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce infectious progeny. These findings suggest that infectious progeny of 2009 A (H1N1) influenza virus could be replicated in and released from human neutrophils with possible clinical implications.

语种: 英语
所属项目编号: 81030033
项目资助者: Major Program of National Natural Science Foundation of China
WOS记录号: WOS:000365854500001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56923
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada
2.Univ Toronto, Dept Immunol, Fac Med, Toronto, ON, Canada
3.Shantou Univ, Coll Med, Collaborat & Creat Ctr, Dept Pathol, Shantou 515041, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Collaborat & Creat Ctr, Prov Key Lab Infect Dis & Immunopathol, Shantou 515041, Guangdong, Peoples R China
5.Beijing Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China
6.Univ Hlth Network, Toronto Gen Res Inst, Div Expt Therapeut, Toronto, ON, Canada
7.Univ Sassari, Sez Microbiol Sperimentale & Clin, Dipartimento Sci Biomed, I-07100 Sassari, Italy
8.Shantou Univ, Coll Med, Int Inst Infect & Immun, Shantou 515041, Guangdong, Peoples R China
9.Shantou Univ, Coll Med, Affiliated Hosp 2, Translat Med Ctr, Shantou 515041, Guangdong, Peoples R China

Recommended Citation:
Zhang, Zhang,Huang, Tao,Yu, Feiyuan,et al. Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils[J]. SCIENTIFIC REPORTS,2015(5).
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