IR@PKUHSC  > 北京大学基础医学院  > 病理学系
学科主题基础医学
Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils
Zhang, Zhang1,2; Huang, Tao1,2; Yu, Feiyuan1,2; Liu, Xingmu1,2; Zhao, Conghui3; Chen, Xueling1,2; Kelvin, David J.4,5,6,7,8; Gu, Jiang1,2,3,9
刊名SCIENTIFIC REPORTS
2015-12-07
DOI10.1038/srep17809
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
资助者Major Program of National Natural Science Foundation of China ; Major Program of National Natural Science Foundation of China
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]RIBONUCLEIC ACID BIOSYNTHESIS ; A H5N1 VIRUS ; AVIAN INFLUENZA ; POLYMORPHONUCLEAR LEUKOCYTES ; RESPIRATORY-TRACT ; RECEPTOR-BINDING ; MESSENGER-RNA ; SIALIC-ACID ; HEMAGGLUTININ ; CELLS
英文摘要

Various reports have indicated that a number of viruses could infect neutrophils, but the multiplication of viruses in neutrophils was abortive. Based on our previous finding that avian influenza viral RNA and proteins were present in the nucleus of infected human neutrophils in vivo, we investigated the possibility of 2009 A (H1N1) influenza viral synthesis in infected neutrophils and possible release of infectious progeny from host cells. In this study we found that human neutrophils in vitro without detectable level of sialic acid expression could be infected by this virus strain. We also show that the infected neutrophils can not only synthesize 2009 A (H1N1) viral mRNA and proteins, but also produce infectious progeny. These findings suggest that infectious progeny of 2009 A (H1N1) influenza virus could be replicated in and released from human neutrophils with possible clinical implications.

语种英语
所属项目编号81030033
资助者Major Program of National Natural Science Foundation of China ; Major Program of National Natural Science Foundation of China
WOS记录号WOS:000365854500001
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56923
Collection北京大学基础医学院_病理学系
作者单位1.Univ Toronto, Inst Med Sci, Fac Med, Toronto, ON, Canada
2.Univ Toronto, Dept Immunol, Fac Med, Toronto, ON, Canada
3.Shantou Univ, Coll Med, Collaborat & Creat Ctr, Dept Pathol, Shantou 515041, Guangdong, Peoples R China
4.Shantou Univ, Coll Med, Collaborat & Creat Ctr, Prov Key Lab Infect Dis & Immunopathol, Shantou 515041, Guangdong, Peoples R China
5.Beijing Univ, Dept Pathol, Hlth Sci Ctr, Beijing 100083, Peoples R China
6.Univ Hlth Network, Toronto Gen Res Inst, Div Expt Therapeut, Toronto, ON, Canada
7.Univ Sassari, Sez Microbiol Sperimentale & Clin, Dipartimento Sci Biomed, I-07100 Sassari, Italy
8.Shantou Univ, Coll Med, Int Inst Infect & Immun, Shantou 515041, Guangdong, Peoples R China
9.Shantou Univ, Coll Med, Affiliated Hosp 2, Translat Med Ctr, Shantou 515041, Guangdong, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Zhang,Huang, Tao,Yu, Feiyuan,et al. Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils[J]. SCIENTIFIC REPORTS,2015(5).
APA Zhang, Zhang.,Huang, Tao.,Yu, Feiyuan.,Liu, Xingmu.,Zhao, Conghui.,...&Gu, Jiang.(2015).Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils.SCIENTIFIC REPORTS(5).
MLA Zhang, Zhang,et al."Infectious Progeny of 2009 A (H1N1) Influenza Virus Replicated in and Released from Human Neutrophils".SCIENTIFIC REPORTS .5(2015).
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