北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 期刊论文
学科主题: 基础医学
题名:
Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression
作者: Yao, Chun-Xia1; Xiong, Cheng-Juan1; Wang, Wei-Ping2; Yang, Fen3; Zhang, Shu-Feng1; Wang, Tian-qi1; Wang, Shu-Ling1; Yu, Huan-Ling4; Wei, Zhi-Ru1; Zang, Ming-Xi1
关键词: GATA-6 ; PPAR alpha ; Glut4 ; transcription activation
刊名: JOURNAL OF MOLECULAR BIOLOGY
发表日期: 2012-01-06
DOI: 10.1016/j.jmb.2011.11.011
卷: 415, 期:1, 页:143-158
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: RECEPTOR-ALPHA ; GLUCOSE-METABOLISM ; COACTIVATOR PGC-1 ; PROTEIN ; MUSCLE ; GAMMA ; HEART ; MITOCHONDRIA ; MICE ; DIFFERENTIATION
英文摘要:

Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear hormone receptor that regulates energy metabolism, but its precise mechanisms remain unknown. Here, we demonstrate that the PPAR alpha agonist fenofibrate activated expression of the glucose transporter Glut4. Moreover, PPAR alpha was associated with the Glut4 promoter through GATA sites upon fenofibrate stimulation in cardiomyocytes. This occupancy is achieved through an interaction between amino acids 1-136 of PPAR alpha with amino acids 276-443 of the cardiac transcription factor GATA-6. In addition, the interaction of PPAR alpha with GATA-6 activated Glut4 gene expression, improved glucose consumption, and enhanced activity of mitochondrial citrate synthase in C2C12 myoblasts; both mutants of PPAR alpha (1-101 aa) and GATA-6 (227-331 aa) were unable to cooperate in Glut4 activation. Thus, GATA-6 is an important component of the transcription network required for energy metabolism mediated by PPAR alpha, and these findings provide a molecular basis for understanding the role of GATA-6 proteins in muscle development and disease. (C) 2011 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2007AA02Z122 ; 082102310024 ; 104300510016
项目资助者: Ministry of Science and Technology of China ; International Cooperation and Exchanges Foundation of Henan Scientific Committee ; Scientific Research Foundation for the Returned Overseas Chinese Scholars ; State Education Ministry and Ministry of Personnel ; Henan University Key Teacher Foundation
WOS记录号: WOS:000299866000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56929
Appears in Collections:基础医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.China Astronaut Res & Training Ctr, Beijing 100094, Peoples R China
2.Zhengzhou Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100069, Peoples R China

Recommended Citation:
Yao, Chun-Xia,Xiong, Cheng-Juan,Wang, Wei-Ping,et al. Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression[J]. JOURNAL OF MOLECULAR BIOLOGY,2012,415(1):143-158.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yao, Chun-Xia]'s Articles
[Xiong, Cheng-Juan]'s Articles
[Wang, Wei-Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yao, Chun-Xia]‘s Articles
[Xiong, Cheng-Juan]‘s Articles
[Wang, Wei-Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace