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学科主题基础医学
Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression
Yao, Chun-Xia1; Xiong, Cheng-Juan1; Wang, Wei-Ping2; Yang, Fen3; Zhang, Shu-Feng1; Wang, Tian-qi1; Wang, Shu-Ling1; Yu, Huan-Ling4; Wei, Zhi-Ru1; Zang, Ming-Xi1
关键词Gata-6 Ppar Alpha Glut4 Transcription Activation
刊名JOURNAL OF MOLECULAR BIOLOGY
2012-01-06
DOI10.1016/j.jmb.2011.11.011
415期:1页:143-158
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]RECEPTOR-ALPHA ; GLUCOSE-METABOLISM ; COACTIVATOR PGC-1 ; PROTEIN ; MUSCLE ; GAMMA ; HEART ; MITOCHONDRIA ; MICE ; DIFFERENTIATION
英文摘要

Peroxisome proliferator-activated receptor alpha (PPAR alpha) is a nuclear hormone receptor that regulates energy metabolism, but its precise mechanisms remain unknown. Here, we demonstrate that the PPAR alpha agonist fenofibrate activated expression of the glucose transporter Glut4. Moreover, PPAR alpha was associated with the Glut4 promoter through GATA sites upon fenofibrate stimulation in cardiomyocytes. This occupancy is achieved through an interaction between amino acids 1-136 of PPAR alpha with amino acids 276-443 of the cardiac transcription factor GATA-6. In addition, the interaction of PPAR alpha with GATA-6 activated Glut4 gene expression, improved glucose consumption, and enhanced activity of mitochondrial citrate synthase in C2C12 myoblasts; both mutants of PPAR alpha (1-101 aa) and GATA-6 (227-331 aa) were unable to cooperate in Glut4 activation. Thus, GATA-6 is an important component of the transcription network required for energy metabolism mediated by PPAR alpha, and these findings provide a molecular basis for understanding the role of GATA-6 proteins in muscle development and disease. (C) 2011 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000299866000013
项目编号2007AA02Z122 ; 082102310024 ; 104300510016
资助机构Ministry of Science and Technology of China ; International Cooperation and Exchanges Foundation of Henan Scientific Committee ; Scientific Research Foundation for the Returned Overseas Chinese Scholars ; State Education Ministry and Ministry of Personnel ; Henan University Key Teacher Foundation
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56929
专题北京大学基础医学院
作者单位1.China Astronaut Res & Training Ctr, Beijing 100094, Peoples R China
2.Zhengzhou Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Zhengzhou 450001, Henan, Peoples R China
3.Peking Univ, Dept Biochem & Mol Biol, Sch Basic Med Sci, Beijing 100191, Peoples R China
4.Capital Med Univ, Sch Publ Hlth & Family Med, Beijing 100069, Peoples R China
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GB/T 7714
Yao, Chun-Xia,Xiong, Cheng-Juan,Wang, Wei-Ping,et al. Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression[J]. JOURNAL OF MOLECULAR BIOLOGY,2012,415(1):143-158.
APA Yao, Chun-Xia.,Xiong, Cheng-Juan.,Wang, Wei-Ping.,Yang, Fen.,Zhang, Shu-Feng.,...&Zang, Ming-Xi.(2012).Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression.JOURNAL OF MOLECULAR BIOLOGY,415(1),143-158.
MLA Yao, Chun-Xia,et al."Transcription Factor GATA-6 Recruits PPAR alpha to Cooperatively Activate Glut4 Gene Expression".JOURNAL OF MOLECULAR BIOLOGY 415.1(2012):143-158.
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