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Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells
Wang, Hecheng1,2,3; Sun, Miao1,2,3; Yang, Huan1,2,3; Tian, Xiaosheng1,2,3; Tong, Yawei1,2,3; Zhou, Ting1,2,3; Zhang, Tao1,2,3; Fu, Yaoyun1,2,3; Guo, Xiangyang4; Fan, Dongsheng4; Yu, Albert1,2,3; Fan, Ming5; Wu, Xuefei6; Xiao, Weizhong4; Chui, Dehua1,2,3,4
关键词Histone deacetylase-1 Hypoxia-inducible factor-1 Neprilysin
刊名JOURNAL OF NEUROCHEMISTRY
2014-10-01
DOI10.1111/jnc.12795
131期:1页:4-11
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]OXIDATIVE STRESS ; ISCHEMIC-INJURY ; EXPRESSION ; ASTROCYTES ; PROTEIN ; BRAIN ; GENERATION ; NEURONS ; ALPHA ; MICE
英文摘要

Hypoxia-inducible factor (HIF)-1 is the key transcriptional activator mediating both adaptive and pathological responses to hypoxia. The purpose of this study was to find the role of HIF-1 in regulating neprilysin (NEP) at the early stage of hypoxia and explore the underlying mechanism. In this study, we demonstrated that both NEP mRNA and protein levels in neuroblastoma cells were elevated in early stages of hypoxia. Over-expression of HIF-1 gene increased NEP mRNA/protein levels, as well as enzyme activity while knockdown of HIF-1 decreased them. Meanwhile, HIF-1 was shown to bind to histone deacetylase (HDAC)-1 and reduced the association of HDAC-1 with NEP promoter, thus activating NEP gene transcription in a de-repression way. In summary, our results indicated that hypoxia in the early stages would up-regulate NEP expression, in which interaction of HIF-1 and HDAC-1 may play a role. This study suggested that NEP up-regulation might be an adaptive response to hypoxia, which was mediated by HIF-1 binding to HDAC-1 at the early stage of hypoxia.

语种英语
WOS记录号WOS:000342849000002
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56931
专题北京大学基础医学院_神经生物学系
北京大学第一临床医学院_肾脏内科
北京大学第三临床医学院_神经内科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Brain Protect & Plast, Beijing 100730, Peoples R China
6.Dalian Med Univ, Dalian 116044, Peoples R China
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Wang, Hecheng,Sun, Miao,Yang, Huan,et al. Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells[J]. JOURNAL OF NEUROCHEMISTRY,2014,131(1):4-11.
APA Wang, Hecheng.,Sun, Miao.,Yang, Huan.,Tian, Xiaosheng.,Tong, Yawei.,...&Chui, Dehua.(2014).Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells.JOURNAL OF NEUROCHEMISTRY,131(1),4-11.
MLA Wang, Hecheng,et al."Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells".JOURNAL OF NEUROCHEMISTRY 131.1(2014):4-11.
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