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学科主题: 基础医学
题名:
Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells
作者: Wang, Hecheng1,2,3; Sun, Miao1,2,3; Yang, Huan1,2,3; Tian, Xiaosheng1,2,3; Tong, Yawei1,2,3; Zhou, Ting1,2,3; Zhang, Tao1,2,3; Fu, Yaoyun1,2,3; Guo, Xiangyang4; Fan, Dongsheng4; Yu, Albert1,2,3; Fan, Ming5; Wu, Xuefei6; Xiao, Weizhong4; Chui, Dehua1,2,3,4
关键词: Histone deacetylase-1 ; Hypoxia-inducible factor-1 ; Neprilysin
刊名: JOURNAL OF NEUROCHEMISTRY
发表日期: 2014-10-01
DOI: 10.1111/jnc.12795
卷: 131, 期:1, 页:4-11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: OXIDATIVE STRESS ; ISCHEMIC-INJURY ; EXPRESSION ; ASTROCYTES ; PROTEIN ; BRAIN ; GENERATION ; NEURONS ; ALPHA ; MICE
英文摘要:

Hypoxia-inducible factor (HIF)-1 is the key transcriptional activator mediating both adaptive and pathological responses to hypoxia. The purpose of this study was to find the role of HIF-1 in regulating neprilysin (NEP) at the early stage of hypoxia and explore the underlying mechanism. In this study, we demonstrated that both NEP mRNA and protein levels in neuroblastoma cells were elevated in early stages of hypoxia. Over-expression of HIF-1 gene increased NEP mRNA/protein levels, as well as enzyme activity while knockdown of HIF-1 decreased them. Meanwhile, HIF-1 was shown to bind to histone deacetylase (HDAC)-1 and reduced the association of HDAC-1 with NEP promoter, thus activating NEP gene transcription in a de-repression way. In summary, our results indicated that hypoxia in the early stages would up-regulate NEP expression, in which interaction of HIF-1 and HDAC-1 may play a role. This study suggested that NEP up-regulation might be an adaptive response to hypoxia, which was mediated by HIF-1 binding to HDAC-1 at the early stage of hypoxia.

语种: 英语
所属项目编号: 2012CB911000 ; 2012CB911004 ; 81171015
项目资助者: National 973 Project of China ; National Natural Science Foundation of China
WOS记录号: WOS:000342849000002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56931
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Beijing 100191, Peoples R China
3.Peking Univ, Dept Neurobiol, Key Lab Neurosci, Minist Educ, Beijing 100191, Peoples R China
4.Peking Univ, Minist Publ Hlth, Hlth Sci Ctr, Beijing 100191, Peoples R China
5.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Brain Protect & Plast, Beijing 100730, Peoples R China
6.Dalian Med Univ, Dalian 116044, Peoples R China

Recommended Citation:
Wang, Hecheng,Sun, Miao,Yang, Huan,et al. Hypoxia-inducible factor-1 alpha mediates up-regulation of neprilysin by histone deacetylase-1 under hypoxia condition in neuroblastoma cells[J]. JOURNAL OF NEUROCHEMISTRY,2014,131(1):4-11.
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