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学科主题: 基础医学
题名:
Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission
作者: Xia, J.; Liu, L.; Wang, L.; Zhang, Y.; Zeng, H.; Liu, P.; Zou, Q.; Wang, L.; Zhuang, H.
关键词: hepatitis E virus ; infection ; mortality ; pregnancy ; vertical transmission
刊名: JOURNAL OF VIRAL HEPATITIS
发表日期: 2015-10-01
DOI: 10.1111/jvh.12406
卷: 22, 期:10, 页:850-857
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
研究领域[WOS]: Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]: WOMEN ; CHINA ; PREVALENCE ; PATHOGENESIS ; INFERTILITY ; OUTBREAK ; FETAL
英文摘要:

A high mortality rate of approximately 20% in pregnant women with hepatitis E has been reported in previous studies. However, other studies showed no difference between pregnant and nonpregnant women in the severity of hepatitis E. To determine the effects of HEV infection on pregnancy, we successfully established HEV infection in six pregnant rabbits (PR) and six nonpregnant rabbits (NPR) with a rabbit HEV isolate, taking three PR and one NPR without HEV infection as controls. Tests for HEV RNA by RT-PCR, anti-HEV antibodies by ELISA and HEV antigen via immunohistochemistry and histopathology were carried out. Two of six infected PR miscarried and three of the remaining four PR died which may be attributed to severe liver necrosis caused by HEV infection. Moreover, vertical transmission was found to be associated with the replication of HEV in placenta, indicated by the presence of HEV RNA and antigen in placenta from the infected PR. Our findings strongly suggest that HEV infection could lead to adverse outcomes in pregnancy and vertical transmission, suggesting the necessity for pregnant women at risk of HEV infection to be vaccinated.

语种: 英语
所属项目编号: 81271827 ; 20120001110098
项目资助者: National Science Foundation of China ; Specialized Research Fund for the Doctoral Program of Higher Education
WOS记录号: WOS:000360769800011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56932
Appears in Collections:基础医学院_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Microbiol & Infect Dis Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Xia, J.,Liu, L.,Wang, L.,et al. Experimental infection of pregnant rabbits with hepatitis E virus demonstrating high mortality and vertical transmission[J]. JOURNAL OF VIRAL HEPATITIS,2015,22(10):850-857.
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