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学科主题: 临床医学
题名:
Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats
作者: Shuai, Xiao-Wei; Xie, Peng-Yan
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2004-08-01
卷: 10, 期:15, 页:2287-2291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To determine the distribution of neurons expressing c-Fos and nitric oxide synthase (NOS) in the central nerve system (CNS) following esophageal acid exposure, and to investigate the relationship between c-Fos and NOS.

METHODS: Twelve Wistar rats were randomly divided into two equal groups. Hydrochloric acid with pepsin was perfused in the lower part of the esophagus for 60 min. As a control normal saline was used Thirty minutes after the perfusion, the rats were killed and brains were removed and processed for c-Fos immunohistochemistry and NADPH-d histochemistry. Blood pressure (BP), heart rate (HR), and respiratory rate (RR) during the experimental procedures were recorded every 10 min.

RESULTS: There were no significant differences in BP, HR and RR between the two groups. c-Fos immunoreactivity was significantly increased in rats receiving acid plus pepsin perfusion in amygdala (AM), paraventricular nucleus (PVN), parabrachial nucleus (PBN), nucleus tractus solitarius and dorsal motor nucleus of vagus (NTS/DMV), nucleus ambiguous (NA), reticular nucleus of medulla (RNM) and area postrema (AP). NOS reactivity in this group was significantly increased in PVN, PBN, NTS/DMV, RNM and AP. c-Fos and NOS had significant correlation between PVN, PBN, NTS/DMV, RNM and AP.

CONCLUSION: Acid plus pepsin perfusion of the esophagus results in neural activation in areas of CNS, and No is likely one of the neurotransmitters in some of these areas.

语种: 英语
所属项目编号: 7042030
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000208317500029
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56944
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China

Recommended Citation:
Shuai, Xiao-Wei,Xie, Peng-Yan. Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(15):2287-2291.
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