IR@PKUHSC  > 北京大学第一临床医学院  > 消化科
学科主题临床医学
Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats
Shuai, Xiao-Wei; Xie, Peng-Yan
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-08-01
10期:15页:2287-2291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

AIM: To determine the distribution of neurons expressing c-Fos and nitric oxide synthase (NOS) in the central nerve system (CNS) following esophageal acid exposure, and to investigate the relationship between c-Fos and NOS.

METHODS: Twelve Wistar rats were randomly divided into two equal groups. Hydrochloric acid with pepsin was perfused in the lower part of the esophagus for 60 min. As a control normal saline was used Thirty minutes after the perfusion, the rats were killed and brains were removed and processed for c-Fos immunohistochemistry and NADPH-d histochemistry. Blood pressure (BP), heart rate (HR), and respiratory rate (RR) during the experimental procedures were recorded every 10 min.

RESULTS: There were no significant differences in BP, HR and RR between the two groups. c-Fos immunoreactivity was significantly increased in rats receiving acid plus pepsin perfusion in amygdala (AM), paraventricular nucleus (PVN), parabrachial nucleus (PBN), nucleus tractus solitarius and dorsal motor nucleus of vagus (NTS/DMV), nucleus ambiguous (NA), reticular nucleus of medulla (RNM) and area postrema (AP). NOS reactivity in this group was significantly increased in PVN, PBN, NTS/DMV, RNM and AP. c-Fos and NOS had significant correlation between PVN, PBN, NTS/DMV, RNM and AP.

CONCLUSION: Acid plus pepsin perfusion of the esophagus results in neural activation in areas of CNS, and No is likely one of the neurotransmitters in some of these areas.

语种英语
WOS记录号WOS:000208317500029
项目编号7042030
资助机构Beijing Natural Science Foundation
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56944
专题北京大学第一临床医学院_消化科
作者单位Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Shuai, Xiao-Wei,Xie, Peng-Yan. Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(15):2287-2291.
APA Shuai, Xiao-Wei,&Xie, Peng-Yan.(2004).Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats.WORLD JOURNAL OF GASTROENTEROLOGY,10(15),2287-2291.
MLA Shuai, Xiao-Wei,et al."Expression and localization of c-Fos and NOS in the central nerve system following esophageal acid stimulation in rats".WORLD JOURNAL OF GASTROENTEROLOGY 10.15(2004):2287-2291.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Shuai, Xiao-Wei]的文章
[Xie, Peng-Yan]的文章
百度学术
百度学术中相似的文章
[Shuai, Xiao-Wei]的文章
[Xie, Peng-Yan]的文章
必应学术
必应学术中相似的文章
[Shuai, Xiao-Wei]的文章
[Xie, Peng-Yan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。