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The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet
Jia, Binbin1; Wang, Xifu2; Kang, Aijun3; Wang, Xuewen3; Wen, Zongyao4; Yao, Weijuan4; Xie, Lide1
关键词Hypercholesterolemia Aerobic Exercise Hemorheology Oxidative Stress
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2012
DOI10.3233/CH-2011-1519
51期:2页:117-127
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]PLASMA VISCOSITY ; BLOOD RHEOLOGY ; FREE-RADICALS ; MECHANISMS ; ATHEROSCLEROSIS ; LIPOPROTEINS ; LIPIDS
英文摘要

Hypercholesterolemia is one of the cardiovascular risk factors sensitive to preventive and control interventions. Here we created a hypercholesterolemia model to investigate the effect of the long term aerobic exercise (swimming) on the hemorheology of rats fed with high-fat diet. We found that the rats fed with high-fat diet developed hypercholesterolemia and hepatic steatosis and their hemorheological and coagulative properties were all impaired as compared to those of the rats fed with standard diet. But after exercise, the total cholesterol and triglyceride in the plasma were significantly decreased and the severity of hepatic steatosis were reduced. Exercise greatly improved the erythrocytes′ hemorheological properties, including deformability, electrophoretic mobility and osmotic fragility. Exercise also markedly lowered the activated partial thromboplastin time (APTT) but had moderate effects on other coagulative parameters. The high oxidative stress level, as indicated by plasma MDA concentration, in rats with high-fat diet was significantly attenuated to the normal level after exercise. The present study suggests that long term aerobic exercise could remarkably improve the abnormal hemorheological property and the oxidative stress in rats with hypercholesterolemia.

语种英语
WOS记录号WOS:000305032200004
项目编号2007000917 ; 20090001120041
资助机构Natural Science Foundation of Hebei Province ; Scientific Research Foundation for Returened Overseas Chinese, State Education Ministry ; State Education Ministry
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56951
专题实验动物科学部
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Chengde Med Coll, Chengde 067000, Hebei Province, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Emergency Dept, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Jia, Binbin,Wang, Xifu,Kang, Aijun,et al. The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2012,51(2):117-127.
APA Jia, Binbin.,Wang, Xifu.,Kang, Aijun.,Wang, Xuewen.,Wen, Zongyao.,...&Xie, Lide.(2012).The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,51(2),117-127.
MLA Jia, Binbin,et al."The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 51.2(2012):117-127.
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