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学科主题: 实验动物
题名:
The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet
作者: Jia, Binbin1; Wang, Xifu2; Kang, Aijun3; Wang, Xuewen3; Wen, Zongyao4; Yao, Weijuan4; Xie, Lide1
关键词: Hypercholesterolemia ; aerobic exercise ; hemorheology ; oxidative stress
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2012
DOI: 10.3233/CH-2011-1519
卷: 51, 期:2, 页:117-127
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: PLASMA VISCOSITY ; BLOOD RHEOLOGY ; FREE-RADICALS ; MECHANISMS ; ATHEROSCLEROSIS ; LIPOPROTEINS ; LIPIDS
英文摘要:

Hypercholesterolemia is one of the cardiovascular risk factors sensitive to preventive and control interventions. Here we created a hypercholesterolemia model to investigate the effect of the long term aerobic exercise (swimming) on the hemorheology of rats fed with high-fat diet. We found that the rats fed with high-fat diet developed hypercholesterolemia and hepatic steatosis and their hemorheological and coagulative properties were all impaired as compared to those of the rats fed with standard diet. But after exercise, the total cholesterol and triglyceride in the plasma were significantly decreased and the severity of hepatic steatosis were reduced. Exercise greatly improved the erythrocytes′ hemorheological properties, including deformability, electrophoretic mobility and osmotic fragility. Exercise also markedly lowered the activated partial thromboplastin time (APTT) but had moderate effects on other coagulative parameters. The high oxidative stress level, as indicated by plasma MDA concentration, in rats with high-fat diet was significantly attenuated to the normal level after exercise. The present study suggests that long term aerobic exercise could remarkably improve the abnormal hemorheological property and the oxidative stress in rats with hypercholesterolemia.

语种: 英语
所属项目编号: 2007000917 ; 20090001120041
项目资助者: Natural Science Foundation of Hebei Province ; Scientific Research Foundation for Returened Overseas Chinese, State Education Ministry ; State Education Ministry
WOS记录号: WOS:000305032200004
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56951
Appears in Collections:实验动物科学部_期刊论文

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作者单位: 1.Chengde Med Coll, Chengde 067000, Hebei Province, Peoples R China
2.Capital Med Univ, Beijing Anzhen Hosp, Emergency Dept, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Lab Anim Sci, Beijing 100191, Peoples R China
4.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Hemorheol Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Jia, Binbin,Wang, Xifu,Kang, Aijun,et al. The effects of long term aerobic exercise on the hemorheology in rats fed with high-fat diet[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2012,51(2):117-127.
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