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学科主题临床医学
Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats
Zhang, Kun1; Thote, Tanushree2,3; Leng, Huijie4; Guldberg, Robert3; Ge, Zigang1,5
关键词Osteoarthritis Pregnancy Cartilage Microcomputed Tomography (Mu Ct)
刊名JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
2013
DOI10.5405/jmbe.1493
33期:5页:449-454
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Wallace H. Coulter GT/Emory-PKU BME Collaborative Research Seed Grant Program ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Wallace H. Coulter GT/Emory-PKU BME Collaborative Research Seed Grant Program
研究领域[WOS]Engineering
关键词[WOS]ARTICULAR-CARTILAGE ; ESTROGEN ; MORPHOLOGY ; THERAPY ; RABBIT ; MODEL ; KNEE ; MICE ; SEX
英文摘要

Hormones, particularly estrogen, are known to play a role in the development of osteoarthritis (OA). In relation to this, the impact of pregnancy on OA remains unknown. Pregnancy leads to decreased expressions of both synthetic and degradation genes of articular chondrocytes, as determined using in vitro tests, but no in vivo studies have been performed exploring pregnancy and OA simultaneously. The present study investigates the effect of pregnancy on the progression of OA in the rat joint degeneration model using an intra-articular injection of monosodium iodoacetate (MIA). Twenty Wistar rats were divided into four groups: A-Pregnancy and intra-articular injection of MIA; B-MIA injection in naive rats; C-Pregnancy, and D-Sham injection of saline in naive rats. Articular cartilage was evaluated 18 days after the detection of vaginal plug in female rats using Janusz′s macroscopic score, equilibrium partitioning of an ionic contrast agent via microcomputed tomography, and glycosaminoglycan (GAG) quantification. Results show that there was no significant difference in GAG content, attenuation, volume, and thickness of articular cartilage between pregnant and non-pregnant groups. Contrary to our initial hypothesis, pregnancy does not have observable effects on MIA-induced OA in rats at 3 weeks.

语种英语
所属项目编号2012CB619102 ; 2012CB619100 ; 81271722
资助者National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Wallace H. Coulter GT/Emory-PKU BME Collaborative Research Seed Grant Program ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Wallace H. Coulter GT/Emory-PKU BME Collaborative Research Seed Grant Program
WOS记录号WOS:000327477900003
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/56957
专题北京大学第三临床医学院_骨科
作者单位1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
3.Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
4.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
5.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Kun,Thote, Tanushree,Leng, Huijie,et al. Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats[J]. JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,2013,33(5):449-454.
APA Zhang, Kun,Thote, Tanushree,Leng, Huijie,Guldberg, Robert,&Ge, Zigang.(2013).Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats.JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,33(5),449-454.
MLA Zhang, Kun,et al."Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats".JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING 33.5(2013):449-454.
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