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学科主题: 临床医学
题名:
Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats
作者: Zhang, Kun1; Thote, Tanushree2,3; Leng, Huijie4; Guldberg, Robert3; Ge, Zigang1,5
关键词: Osteoarthritis ; Pregnancy ; Cartilage ; Microcomputed tomography (mu CT)
刊名: JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING
发表日期: 2013
DOI: 10.5405/jmbe.1493
卷: 33, 期:5, 页:449-454
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical
研究领域[WOS]: Engineering
关键词[WOS]: ARTICULAR-CARTILAGE ; ESTROGEN ; MORPHOLOGY ; THERAPY ; RABBIT ; MODEL ; KNEE ; MICE ; SEX
英文摘要:

Hormones, particularly estrogen, are known to play a role in the development of osteoarthritis (OA). In relation to this, the impact of pregnancy on OA remains unknown. Pregnancy leads to decreased expressions of both synthetic and degradation genes of articular chondrocytes, as determined using in vitro tests, but no in vivo studies have been performed exploring pregnancy and OA simultaneously. The present study investigates the effect of pregnancy on the progression of OA in the rat joint degeneration model using an intra-articular injection of monosodium iodoacetate (MIA). Twenty Wistar rats were divided into four groups: A-Pregnancy and intra-articular injection of MIA; B-MIA injection in naive rats; C-Pregnancy, and D-Sham injection of saline in naive rats. Articular cartilage was evaluated 18 days after the detection of vaginal plug in female rats using Janusz′s macroscopic score, equilibrium partitioning of an ionic contrast agent via microcomputed tomography, and glycosaminoglycan (GAG) quantification. Results show that there was no significant difference in GAG content, attenuation, volume, and thickness of articular cartilage between pregnant and non-pregnant groups. Contrary to our initial hypothesis, pregnancy does not have observable effects on MIA-induced OA in rats at 3 weeks.

语种: 英语
所属项目编号: 2012CB619102 ; 2012CB619100 ; 81271722
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Wallace H. Coulter GT/Emory-PKU BME Collaborative Research Seed Grant Program
WOS记录号: WOS:000327477900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56957
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
2.Georgia Inst Technol, Wallace H Coulter Dept Biomed Engn, Atlanta, GA 30332 USA
3.Georgia Inst Technol, Parker H Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA
4.Peking Univ, Hosp 3, Dept Orthopaed, Beijing 100191, Peoples R China
5.Peking Univ, Acad Adv Interdisciplinary Studies, Ctr Biomed Mat & Tissue Engn, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Kun,Thote, Tanushree,Leng, Huijie,et al. Effects of Pregnancy on Progression of Osteoarthritis Induced by Monosodium Iodoacetate in Rats[J]. JOURNAL OF MEDICAL AND BIOLOGICAL ENGINEERING,2013,33(5):449-454.
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