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学科主题: 临床医学
题名:
Detection of TERC Amplification in Cervical Epithelial Cells for the Diagnosis of High-Grade Cervical Lesions and Invasive Cancer A Multicenter Study in China
作者: Jiang, Jing1; Wei, Li-Hui1; Li, Ya-Li2; Wu, Rui-Fang3; Xie, Xing4; Feng, You-Ji5; Zhang, Guo1; Zhao, Chao1; Zhao, Yun1; Chen, Zhong6
刊名: JOURNAL OF MOLECULAR DIAGNOSTICS
发表日期: 2010-11-01
DOI: 10.2353/jmoldx.2010.100021
卷: 12, 期:6, 页:808-817
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: ATYPICAL SQUAMOUS CELLS ; TELOMERASE GENE TERC ; HUMAN-PAPILLOMAVIRUS ; INTRAEPITHELIAL NEOPLASIA ; UNDETERMINED SIGNIFICANCE ; GENOMIC AMPLIFICATION ; WOMEN ; RISK ; HPV ; TESTS
英文摘要:

Because the activation of telomerase is a relatively early event m the progression of cervical carcinogenesis, the expression of the human telomerase RNA gene, TERC, has the potential to serve as a biomarker for both the diagnosis and prognosis of cervical neoplasias In total, 83 research centers participated in the study, and 7786 patients were enrolled TERC amplification was detected using a dual color fluorescence in situ hybridization (FISH) probe set, and these results were compared with cytological and histological results, testing for high risk human papillomavirus (HPV) DNA (n = 2316 for the HPV DNA test), as well as patient age TERC amplification was found to be increased in more advanced cases of cervical carcinogenesis Moreover, a Youden′s index value and the area under the receiver operating characteristic (ROC) curve were also calculated for samples with TERC amplification and found to be higher than the same values calculated for both cytology and high risk HPV analyses of the same samples With regard to cytological ASCUS and LSIL findings, the combination of HPV + TERC testing showed the potential to pro vide effective triaging to detect CIN2(+) Therefore, TERC amplification represents a valuable genetic biomarker, which m combination with an evaluation of cytology or HPV testing, can achieve higher sensitivity and specificity in distinguishing high grade cervical lesions and invasive cancers from low grade lesions compared with conventional methods (J Mol Diagn 2010, 12 808-817, DOI 10.2353/jmoldx.2010.100021)

语种: 英语
所属项目编号: WKJ 2007 3 001
项目资助者: Ministry of Health of the Peoples Republic of China
WOS记录号: WOS:000283973700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56961
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100044, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Obstet & Gynecol, Shenzhen, Peoples R China
4.Hejiang Univ, Womens Hosp, Sch Med, Dept Obstet & Gynecol, Hangzhou, Peoples R China
5.Fudan Univ, Gynecol & Obstet Hosp, Dept Obstet & Gynecol, Shanghai 200433, Peoples R China
6.Univ Utah, Sch Med, Div Med Genet, Salt Lake City, UT USA

Recommended Citation:
Jiang, Jing,Wei, Li-Hui,Li, Ya-Li,et al. Detection of TERC Amplification in Cervical Epithelial Cells for the Diagnosis of High-Grade Cervical Lesions and Invasive Cancer A Multicenter Study in China[J]. JOURNAL OF MOLECULAR DIAGNOSTICS,2010,12(6):808-817.
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