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学科主题: 临床医学
题名:
The Differential Expression of Vascular Endothelial Growth Inhibitor Isoforms, VEGI251, VEGI174 and VEGI192 in Human Clear-cell Renal Cell Carcinoma
作者: Zhang, Ning1,2; Wu, Pengjie3; Wu, Liyang1; Shayiremu, Duoerkun4; Shan, Hui1; Ye, Lin2,5; Jiang, Wen G.2,5; Gong, Kan; Yang, Yong1
刊名: CANCER GENOMICS & PROTEOMICS
发表日期: 2013
卷: 10, 期:1, 页:47-53
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Genetics & Heredity
研究领域[WOS]: Oncology ; Genetics & Heredity
关键词[WOS]: TNF-LIKE LIGAND ; CANCER CELLS ; TUMOR-GROWTH ; IN-VITRO ; T-CELL ; ANGIOGENESIS ; TL1A ; CYTOKINE ; SUPERFAMILY ; RECEPTOR
英文摘要:

Vascular endothelial growth inhibitor (VEGI) is a recently identified antiangiogenic cytokine that belongs to the tumour necrosis factor (TNF) superfamily, and may be essential for many physiological and pathological processes. However, the expression of VEGI and in particular its isoforms, VEGI251, VEGI192 and VEGI174, in clear-cell renal cell carcinoma (CCRCC) remain unknown. In the current study, we investigated the expression of the three isoforms of VEGI in CCRCC. The expression of VEGI was examined in paired human normal renal and CCRCC specimens (n= 73). The transcripts of the three isoforms of VEGI were all detected in human renal normal and tumour tissues. Levels of VEGI174 and VEGI192 transcripts in normal renal specimens were higher than those in CCRCC (p= 0.021 and p= 0.038, respectively). Levels of VEGI251 were similar in normal and tumour specimens (p= 0.67). The numbers of VEGI174 and VEGI192 transcripts in T1a+ T1b tumours were higher than those in T2+ T3 tumours (p= 0.006 and p= 0.018, respectively). Moreover, VEGI192 transcript levels were negatively correlated with pathological nuclear grade (r=-0.216, p= 0.022). In immunohistochemical staining, VEGI192 staining in normal and CCRCC tissues differed significantly (100% vs. 39.7%, p< 0.0001). VEGI192 staining intensity was also negatively correlated with pathological nuclear grade (r=-0.781, p= 0.002). Conclusion: Transcripts of VEGI isoforms were detectable in normal and tumour renal tissues. VEGI192 and VEGI174 expressions markedly decreased in CCRCC and are linked to pathological grade and stage. VEGI192 and VEGI174 are more likely to be putative tumour suppressive factors and a potential therapeutic target in CCRCC.

语种: 英语
所属项目编号: 81072088
项目资助者: National Natural Science Foundation of China ; Cancer Research Wales ; Albert Hung Foundation
WOS记录号: WOS:000339392800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/56968
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Beijing Chaoyang Hospital
2., Dept Urol, Beijing, Peoples R China
3.Capital Med Univ, Cardiff Univ, Joint Ctr Biomed Res, Beijing 100020, Peoples R China
4.Peking Univ First Hosp, Dept Urol, Beijing, Peoples R China
5.Cent Hosp HaMi Reg XinJiang Prov, Dept Urol, Hami, Xinjiang, Peoples R China
6.Cardiff Univ, Sch Med, Metastasis & Angiogenesis Res Grp, Cardiff CF10 3AX, S Glam, Wales

Recommended Citation:
Zhang, Ning,Wu, Pengjie,Wu, Liyang,et al. The Differential Expression of Vascular Endothelial Growth Inhibitor Isoforms, VEGI251, VEGI174 and VEGI192 in Human Clear-cell Renal Cell Carcinoma[J]. CANCER GENOMICS &amp; PROTEOMICS,2013,10(1):47-53.
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